Rapid fire facts Flashcards

1
Q

most common cause of neural tube defects

A

folate deficiency

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2
Q

most common preventable cause of congenital malformations in the U.S.

A

alcohol use

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3
Q

hyperflexible joints, arachnodactyly, aortic dissection, lens dislocation

A

marfan syndrome

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4
Q

hereditary nephritis, cataracts, sensorineural hearing loss

A

Alport syndrome

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5
Q

“worst headache of my life”

A

subarachnoid hemorrhage

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6
Q

lucid interval following head trauma

A

epidural hematoma

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7
Q

bloody CSF on Lumbar puncture

A

subarachnoid hemorrhage

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8
Q

most common cause of subdural hematoma

A

rupture of bridging vein

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9
Q

most common cause of epidural hematoma

A

rupture of middle meningeal artery

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10
Q

most common cause of dementia

A

alzheimers

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11
Q

second most common cause of dementia

A

vascular dementia

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12
Q

extracellular amyloid deposits in the gray matter

A

amyloid plaques in alzheimers

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13
Q

intracellular deposits of hyperphosphorylated tau protein

A

neurofibrillary tangles in alzheimers

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14
Q

intracellular spherical aggregates of tau protein seen on silver stain

A

pick bodies of frontotemporal dementia (pick disease)

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15
Q

treatment for absence seizures

A

ethosuximide

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16
Q

conjugate lateral gaze palsy ,with nystagmus and diplopia during lateral gaze

A

intranuclear opthalmophegia

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17
Q

degeneration of the dorsal columns

A

tabes dorsalis (4th stage of syphillis)

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18
Q

demyelinating disease in a young woman

A

multiple sclerosis

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19
Q

mixed upper and lower motor neuron disease

A

amyotrophic lateral sclerosis

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20
Q

depigmentation of the substantia nigra

A

parkinson disease

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21
Q

chorea, dementia, and atrophy of the caudate and the putamen

A

Huntingon disease

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22
Q

eosinophilic inclusions in the cytoplasm of neurons

A

Lewy bodies

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23
Q

toe extension upon stimulating the sole of the foot with a blunt instrument

A

+ babinski reflex

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24
Q

newborn with arm paralysis following a difficult labor

A

erb-duchenne palsy

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25
Q

drooling farmer

A

organophosphate poisoning

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26
Q

medical treatment for pheochromocytoma

A

alpha agonist

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27
Q

selective alpha1 antagonist used to treat BPH

A

tamsulosin

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28
Q

continuous, machinery like heart murmur

A

patent ductus arteriosus

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29
Q

“boot shaped heart”

A

tetralogy of fallot

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30
Q

rib notching

A

coarctation of the aorta

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31
Q

most common congenital cardiac anomaly

A

ventricular septal defect (VSD)

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32
Q

most common congenital cause of early cyanosis

A

tetralogy of fallot

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33
Q

bounding pulses, head bobbing, diastolic murmur

A

aortic regurgitation

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34
Q

chest pain, pericardial friction rub, and persistent fever occurring several weeks after an MI

A

dressler syndrome

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35
Q

splinter hemorrhages under the fingernails

A

infective endocarditis

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36
Q

retinal hemorrhages with pale centers

A

Roths spots-infective endocarditis

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37
Q

heart valve most commonly involved in infective endocarditis

A

mitral valve

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38
Q

heart valve most commonly involved in an IV drug user with infective endocarditis

A

tricuspid valve

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39
Q

granulomatous nodules in the heart

A

aschoff bodies (rheumatic fever)

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40
Q

most common primary cardiac tumor in adults

A

myxoma (left atrium)

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41
Q

most common primary cardiac tumor in children

A

rhabdomyoma (associated with tuberous sclerosis)

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42
Q

most common cause of constrictive pericarditis

A

Lupus in U.S., T.B. in developing countries

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43
Q

c-ANCA

A

granulamatosis with polyangitis

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44
Q

p-ANCA

A

Eosinophilic granulomatosis with polyangitis (Churg-Strauss), microscopic polyangitis

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45
Q

treatment for thromboangitis obliterans

A

STOP SMOKING!

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46
Q

treatment for giant cell arteritis

A

high dose steroids for several months

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47
Q

bone enlargement, bone pain, arthritis

A

paget disease of the bone

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48
Q

vertebral compression fractures

A

osteoporosis

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49
Q

positive anterior drawer sign

A

ACL tear

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50
Q

tenderness in the anatomical snuffbox

A

scaphoid fracture

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51
Q

swollen, hard, painful finger joints

A

osteoathritis

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52
Q

swollen, boggy, painful finger joints

A

rheumatoid arthritis

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53
Q

cartilage erosion with polished bone beneath

A

osteoarthritis

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54
Q

swollen, red, acutely painful great toe joint

A

gout..”podagra”

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55
Q

Positively birefrigent rhomboid shaped crystals

A

pseudogout (calicum pyrophosphate crystals). blue are parallel and yellow are perpendicular

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56
Q

Negatively birefrigent needle shaped crystals

A

Gout (monosodium urate (MSU) crystals). yellow is parallel and blue is perpendicular

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57
Q

bamboo spine on xray

A

ankylosing spondylitis

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58
Q

HLA-B27

A

seronegative spondyloarthropathies

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59
Q

pencil-in-cup deformity on xray of the finger

A

psoriatic arthritis

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60
Q

Anti-smith and anti-dsDNA antibodies

A

SLE

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61
Q

anti-histone antibodies

A

drug induced Lupus, but can see with SLE

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62
Q

anti-centromere antibodies

A

CREST scleroderma

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63
Q

anti-topoisomerase antibodies (anti-Scl70)

A

diffuse scleroderma

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64
Q

Anti-Jo-1 antibodies

A

polymyositis

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65
Q

Anti-Ro antibodies (anti SSA, SSB)

A

Sjogren syndrome

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66
Q

arthritis, dry mouth, and dry eyes

A

sjogren syndrome

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67
Q

keratin pearls on skin biopsy

A

squamous cell carcinoma

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68
Q

most common malignant skin tumor

A

Basal cell carcinoma

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69
Q

main artery of the pelvis

A

internal iliac artery

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70
Q

main nerve of the pelvis

A

pudendal n.

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71
Q

“bag of worms” scrotum

A

varicocele

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72
Q

most common cancer in men

A

prostate cancer

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73
Q

most common cause of urinary obstruction in men

A

BPH

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74
Q

most common treatment of erectile dysfunction

A

phosphodiesterase inhibitors

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75
Q

Hepatic adenoma

A

OCP use

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76
Q

“grape like” vaginal tumor

A

sacroma botryoides

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77
Q

koilocytes (enlarged nuclei, cytoplasmic clearing around nuclei, “perinuclear halos”)

A

HPV infectin

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78
Q

most common benign tumor in women

A

leiomyomas (fibroids)

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79
Q

“chocolate cyst” of the ovary

A

endometriomas

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80
Q

“powder burn” lesion

A

endometriosus

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81
Q

most common cause of infertility in women

A

PCOS

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82
Q

midcycle pelvic pain associated with ovulation

A

mittelschmerz

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83
Q

ovarian tumor +ascites+hydrothorax

A

Meigs syndrome

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84
Q

teratoma –> hyperthyroidism

A

struma ovarii

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85
Q

“snowstorm”appearance on ultrasound

A

hydatidiform mole

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86
Q

most common genetic cause of intellectual disability

A

down syndrome

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87
Q

second most common genetic cause of intellectual disability

A

fragile X syndrome

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88
Q

horseshoe kidney, congenital heart defects, streak ovaries, and cystic hygroma

A

turner syndrome

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89
Q

rocker-bottom feet, clenched hands, microcephaly with prominent occiput and small jaw

A

edwards syndrome

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90
Q

most common cause overall of intellectual disability

A

fetal alcohol syndrome

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91
Q

most common cancer in women in the us

A

Breast cancer

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92
Q

most common benign breast tumor

A

fibroadenoma

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93
Q

most common malignant breast tumor

A

invasive ductal carcinoma

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94
Q

blue dome cyst in the breast

A

fibrocystic change

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95
Q

treatment for ER(+) breast cancer

A

tamoxifen

96
Q

red, itchy, swollen rash on the areola and nipple

A

paget disease of the breast

97
Q

branching, filamentous, gram positive rods with sulfur granules

A

actinomyces israeli

98
Q

standard treatment for T.pallidum

A

Penicillin G, if PCN allergy doxycycline

99
Q

cellulitis from a dog or cat bite

A

pasteurella multocida

100
Q

a non-painful, indurated, ulcerated genital lesion

A

chancre of primary syphilis

101
Q

moist, smooth, white, flat genital lesion

A

condyloma lata (secondary syphilis)

102
Q

large bulls eye rash

A

lyme disease (erthema migrans)

103
Q

associated with a Ghon focus or Ghon complex + hilar lymphadenopathy

A

primary tuberculosis

104
Q

associated with lung infiltrate in the apical posterior segments of upper lobes

A

reactivated TB

105
Q

standard initial treatment regimen for TB

A

rifampin, INH, pyrazinamide,ethambutol

106
Q

“strawberry” cervix

A

trichomonas vaginalis

107
Q

clue cells

A

gardnerell vaginalis

108
Q

bacteria with “school of fish” appearance

A

Chancroid- haemophilus ducreyi

109
Q

dark purple lesions on the skin in an HIV patient

A

Kaposi Sarcoma (HHV-8)

110
Q

temporal lobe encephalitis

A

HSV-1

111
Q

“Owls-eye” inclusions in organ tissue

A

CMV

112
Q

intranuclear eosinophilic droplets

A

Type A cowdry bodies (HSV, VZV, CMV)

113
Q

aplastic anemia in sickle cell patient

A

parvovirus B19

114
Q

child with fever and “slapped cheek” rash on the face that spreads to the body

A
Erthema infectiosum(also known as fifth disease)
caused by parvovirus B19
115
Q

fever, runny noses, cough , conjuctivitis,and diffuse rash

A

Rubeola (measles)

116
Q

small, irregular, blue-gray spots on the buccal mucosa, surrounded by a base of red

A

Koplik’s spots (measles)

117
Q

large cells with “owls eye inclusions”

A

CMV

118
Q

treatment for CMV

A

ganglicyclovir

119
Q

most common opportunistic infection in HIV patients

A

pneumocystis pneumonia

120
Q

drugs used to PREVENT/prophylaxis pneumocystic pneumonia

A

TMP-SMX

121
Q

treatment for oral candidiasis

A

nystatin, fluconazole

122
Q

treatment for sytemic candidiasis

A

fluconazole, amphotericin B, echinocandin

123
Q

treatment for sporothrix schenckii

A

itraconazole, potassium iodide

124
Q

ring enhancing brain lesion in HIV patient

A

toxoplasma gondii

125
Q

treatment for trichomonas vaginalis

A

metronidazole

126
Q

most common protozoal diarrhea

A

giardia lamblia

127
Q

eczema, recurrent cold absecess, high serum IgE

A

hyper IgE syndrome (Job syndrome)

128
Q

large phagosomal vesicles in neutrophils

A

Chediak Higashi syndrome

129
Q

dyphagia, glossitis, and iron deficiency anemia

A

plummer vinson syndrome

130
Q

hematemesis with retching

A

mallory weiss tear

131
Q

mucin filled cell with a peripheral nucleus

A

signet ring seen in lobular carcinoma insitu of the breast and gastric adenocarcinoma

132
Q

most common type of stomach cancer

A

adenocarcinoma

133
Q

ovarian metastasis from gastric cancer

A

krukenberg tumor

134
Q

gastric ulcerations and high gastrin levels

A

Zollinger ellison syndrome

135
Q

acute gastric ulcer associated with elevated ICP or head trauma

A

cushing ulcer

136
Q

acute gastric ulcer associated with severe burns

A

curling ulcer

137
Q

weight loss, diarrhea, arthritis, fever, adenopathy, and hyperpigementation

A

whipple disease

138
Q

anti-transglutaminase/anti-gliadin antibodies

A

Celiac disease

139
Q

vitamin given to pregnant women to prevent neural tube defect

A

folic acid

140
Q

most common surgical emergency

A

appendicitis

141
Q

severe RLQ pain with rebound tenderness

A

appendicitis

142
Q

GI hamartomas, hyperpigmentation of the mouth and hands

A

peutz-jeghers syndrome

143
Q

multiple colon polyps, osteomas, soft tissue tumors

A

gardner syndrome

144
Q

Apple core lesion on barium enema

A

colon cancer

145
Q

most common site of colonic diverticula

A

sigmoid colon

146
Q

“string sign” on contrast xray

A

crohns disease

147
Q

“lead pipe”(loss of haustra) appearance of colon on contrast xray

A

ulcerative colitis

148
Q

painless jaundice

A

pancreatic adenocarcinoma

149
Q

most common cause of acute pancreatitis

A

gallstones, alcohol

150
Q

most common cause of chronic pancreatitis

A

alcohol abuse

151
Q

severe hyperbilirubinemia in a neonate

A

Crigler-Najjar syndrome type 1

152
Q

mild, benign hyperbiliruninemia

A

gilbert syndrome

153
Q

triglyceride accumulation in hepatocytes

A

fatty liver disease

154
Q

eosinophilic inclusions in the cytoplasm of the hepatocytes

A

mallory bodies

155
Q

cancer closely linked to cirrhosis

A

hepatocellular carcinoma

156
Q

hepatomegaly. abdominal pain, ascites

A

Budd Chiari syndrome

157
Q

green/yellow corneal deposits

A

wilson disease

158
Q

low serum cerulospamin

A

wilson disease

159
Q

cirrhosis, diabetes, and hyperpigmentation

A

hemochromatosis

160
Q

chronic sinusitis, infertility and situs inversus

A

kartagener syndrome (Defective dynein)

161
Q

Elevated DDimer

A

PE, DVT

162
Q

hypercoagulability, endothelial damage, stasis of blood

A

virchow’s triad

163
Q

blue bloater

A

chronic bronchitis

164
Q

pink puffer

A

emphysema

165
Q

curshmann spirals

A

asthma

166
Q

bilateral hilar adenopathy, uveitis

A

sarcoidosis

167
Q

Anti-glomerular basement membrane antibodies

A

good pasture syndrome

168
Q

honeycomb lung on x-ray

A

idiopathic pulmonary fibrosis

169
Q

“tennis racket” shaped cytoplasmic organelles

A

Birbeck granules of langerhan cell histiocytosis

170
Q

iron containing nodules in the alveolar septum

A

ferruginous bodies (asbestos)

171
Q

lung cancer associated with SIADH

A

small cell carcinoma

172
Q

tumor associated with horner syndrome

A

pancoast tumor

173
Q

lung cancer associated hypercalcemia

A

squamous cell carcinoma (increased PTH secretion)

174
Q

lung cancer associated with cushing syndrome

A

(increased ACTH) small cell carcinoma

175
Q

lung cancer associated with weakness

A

small cell carcinoma

176
Q

substances associated with lung cancer

A

smoke, radon, silica, asbestos

177
Q

a boy with self mutilating behavior, intellectual disability, and gout

A

Lesh-Nyhan syndrome

178
Q

orotic acid in the urine + elevated serum ammonia

A

ornithine transcarbamoylase deficiency

179
Q

orotic acid in the urine + normal serum ammonia

A

orotic aciduria

180
Q

megaloblastic anemia that does not improve with folate and B12

A

orotic aciduria

181
Q

bluish colored lines on the gingivae

A

Burton’s lines (lead poisoning)

182
Q

treatment of choice for rickets or osteomalacia

A

vitamin D

183
Q

swollen gums, poor wound healing, bleeding mucous membranes, and spots on the skin

A

scurvy (vitamin C deficiency)

184
Q

most common vitamin deficiency in the US

A

folate (B9) deficiency

185
Q

hypersegmented neutrophils

A

megaloblastic anemia

186
Q

dilated cardiomyopathy, edema, and polyneuropathy

A

Wet Beriberi (thiamine deficiency)

187
Q

most common class of medication for bulimia nervosa

A

SSRIs (fluoxetine)

188
Q

most common medication for ADHD

A

methylphenidate (Ritalin)

189
Q

medical treatment for alcohol withdrawal

A

benzodiazepines

190
Q

most effective treatment for alcohol abuse

A

alcoholics anonymous

191
Q

atrophy of the mammillary bodies

A

wernicke encephalopathy

192
Q

treatment for central Diabetes Insipidus

A

desmospressin

193
Q

treatment for nephrogenic diabetes insipidus

A

HCTZ, indomethacin, amiloride

194
Q

treatment for lithium-induced nephrogenic diabetes insipidus

A

amiloride

195
Q

inability to breastfeed, amenorrhea, cold intolerance

A

sheehan syndrome

196
Q

infertility, galactorrhea, and bitemporal hemianopia

A

hyperprolactin (prolactinoma)

197
Q

most common causes of cushing syndrome

A

iatrogenic exogenous corticosteroid therapy (1st)
pituitary adenoma (2nd)
non-pituitary tumor or cancer that produces ectopic ACTH (small cell lung cancer)
adrenal overproduction of cortisol (adrenal adenoma)

198
Q

most common cause of primary hyperaldosteronism

A

adrenal adenoma

199
Q

medical treatment for hyperaldosteronism

A

spironolactone or eplerenone

200
Q

adrenal disease associated with skin hyperpigmentation

A

addison disease

201
Q

HTN, hypokalemia, metabolic alkalosis

A

hyperaldosteronism

202
Q

most common tumor of the adrenal

A

Benign, nonfunctioning adrenal adenoma

203
Q

most common tumor of the adrenal medulla in adults

A

pheochromocytoma (chromaffin cell tumor)

204
Q

most common tumor of the adrenal medulla in children

A

neuroblastoma (tumor of sympathetic ganglion cells)

205
Q

pheochromocytoma, medullary thyroid cancer, and hyperparathyroism

A

MEN2A

206
Q

pheochromoctyoma, medullary thyroid cancer, and mucosal neuromas

A

MEN2B

207
Q

medical treatment for pheochromocytoma

A

alpha nonselective blocker (can add beta blocker for increased heart rate but never give beat blocker by itself because the epi released from the pheochromocytoma will still activate the alpha receptors and INCREASE BP even more

208
Q

cold intolerance

A

hypothyroidism

209
Q

most common thyroid cancer

A

papillary thyroid cancer

210
Q

enlarged thyroid cells with ground glass nuclei

A

papillary thyroid cancer

211
Q

most common cause of hypercalcemia

A

primary hyperparathyroidism

212
Q

most common cause of primary hyperparathyroidism

A

solitary parathyroid adenoma

213
Q

most common cause of secondary hyperparathyroidism

A

chronic renal failure–> hypocalcemia

214
Q

most common cause of hypoparathyroidism

A

accidental parathyroidectomy

215
Q

facial muscle spasm when tapping on the cheek

A

chvostek sign

216
Q

parathyroid, pancreatic, and pituitary tumors

A

MEN1

217
Q

preferred anticoagulant for immediate anticoagulation

A

heparin/LMWH

218
Q

preferred anticoagulant for long term anticoagulation

A

warfarin

219
Q

preferred anticoagulant during pregnancy

A

hepain/LMWH

220
Q

causes of hypochromic, microcytic anemia

A

iron deficiency anemia, thalassemia, lead poisoning, anemia of chronic disease

221
Q

skull xray shows “hair on end” appearance

A

Beta thalassemia, sickle cell disease

222
Q

basophilic stippling of RBCs

A

lead poisoning

223
Q

painful cyanosis of the finger and toes with hemolytic anemia

A

cold autoimmune hemolytic anemia

224
Q

red urine in the morning and fragile RBCs

A

paroxysmal nocturnal hemoglobinuria

225
Q

basophilic nuclear remnants in the RBCs

A

Howell-Jolly bodies

226
Q

autosplenectomy

A

sickle cell disease

227
Q

drug used to treat sickle cell disease

A

hydroxyurea (increases production of HbF)

228
Q

antiplatelet antibodies (gbIIb/IIIa)

A

immune thrombocytopenia (ITP)

229
Q

bleeding disorder with gp1b deficiency

A

Bernard-Soulier disease

230
Q

most common inherited bleeding disorder

A

von willebrand disease (tx: DDAVP)

231
Q

gb IIb/IIIa defect

A

glanzamann’s thrombasthenia

232
Q

cancer most commonly associated with a noninfectious fever

A

hodgkin lymphoma

233
Q

sheets of lymphoid cells, “starry sky” appearance

A

burkitt lymphoma

234
Q

large B cells with bilobed nuclei and prominent “owl’s eye inclusions”

A

Reed sternberg cell (hodgkins lymphoma)

235
Q

smudge cells

A

CLL

236
Q

reddish pink rods in the cytoplasm of leukemic blasts

A

Auer rods