Ranolazine Flashcards
1
Q
what is it?
A
novel metabolic modulator
2
Q
MOA
A
unknown
partial fatty acid oxidase inhibitor–> increases glucose oxidation–> increased O2 utilization efficiency in heart
3
Q
Effects
A
No effect on HR or BP
4
Q
Indications
A
chronic stable angina
in combination w/:
- -amlodapine,
- -BBs, or
- -Nitrates
5
Q
acute anginal attacks
A
will not relieve
6
Q
Problems
A
Pregnancy category C
Expensive w/ only marginal benefit
7
Q
Contraindications
A
use w/ cyp3A inhibitors
hepatic impairment
