Randoms

Question 1

Why Hydroxy groups form stronger hydrogen bonds) compared to ester groups?

Answer 1

Due to electronic and steric factors in case of the ester groups.

Question 2

Define Binding groups

Answer 2

Functional groups on a drug which are used to bind it to the drug target.

Question 3

Define Potency of a drug

Answer 3

The amount of drug required to produce a defined biological effect.

Question 4

Pharmacokinetics

Answer 4

The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by absorption, distribution, metabolism, and excretion

Question 5

Define Binding site

Answer 5

hollow or cleft present on the surface of a macromolecule to which a drug can bind.

Question 6

Define Lead compound

Answer 6

A molecule that shows some activity or property of interest and serves as the starting point for the development of a drug.

Question 7

Define Antagonist

Answer 7

A drug that binds to a receptor, fails to activate it and prevents the endogenous chemical messenger from binding

Question 8

Define Affinity of a drug

Answer 8

The measure of how strongly a drug binds to a receptor.

Question 9

Define Efficacy of a drug

Answer 9

The maximum biological effect resulting from a drug binding to its target.

Question 10

Define Structure-Activity Relationship (SAR)

Answer 10

The study of which functional groups are important in binding a drug to its target binding site, and the identification of a pharmacophore