Random Tidbits Flashcards
1
Q
What are the potential medical conditions related to Protamine reaction?
A
Diabetes (some insulins are complexed with protamine to increase duration of action, causing the body to create antibodies)
Infertile or castrated men (antibody production)
fish allergy (Protamine is synthesized from salmon sperm and cross-reactivity is possible)
2
Q
What are the signs and symptoms of Protamine reaction?
A
Cutaneous manifestations of anaphylaxis have been observed (edema, rash, etc)
Systemic vasodilation coupled with pulmonary vasoconstriction and global cardiovascular failure
