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SBL 1 > Random Stuff I can't get > Flashcards

Random Stuff I can't get Flashcards

1
Q

11:14 translocation?

A

mantle cell lymphoma

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2
Q

IgH next to Cyclin D1?

A

Mantle cell lymphoma

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3
Q

CD25 and CD11c

A

Hairy cell leukemia

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4
Q

Popcorn cells

A

Nodular Hodgkins lymphohma

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5
Q

8:21 translocation?

A

AML with neutrophilic maturation seen in young patients with a good prognosis

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6
Q

RUNX-RUNX1T1?

A

AML t(8:21) seen in younger patients good prognosis, neutrophilic maturation

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7
Q

15:17?

A

APL subclass of AML has auer rods

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8
Q

PML-RARa?

A

APL tx with retionic acid

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9
Q

ALK+ or ALK-?

A

ALCL

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10
Q

Cloverleaf assoc. with HTLV-1

A

Adult T cell

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11
Q

9:22

A

CML

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12
Q

Tennis Racket Birbek granuels

A

Langerhans Cell Histiocytosis

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13
Q

8:14

A

Burkitts

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14
Q

IgH/MYC

A

Burkitts

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15
Q

Tingible Body macrophages?

A

Burkitts

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16
Q

12:21

A

ALL, good prognosis

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17
Q

Arrest of lymphocytic cells, large dark nucleus, agranular, dense packed bone marrow, TdT present on cells

A

ALL common in kids

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18
Q

Undergoes RIchter transformation with mutations involving P53 or MYC

A

CLL/SLL

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19
Q

14:18

A

Follicular lymphoma

20
Q

IgH/BCL-2

A

Follicular lymphoma

21
Q

Painless lymphadenopathy IgH translocated next to BCL2?

A

Follicular lymphoma

22
Q

PIGA mutation

A

PNH

23
Q

Howell Jolly bodies?

A

HS

24
Q

Heinz bodies?

A

G6PD deficiency, Hgb denatured

25
Q

High homocystein levels only

A

Folate deficiency

26
Q

High homocystein and MM/CoA

A

B12

27
Q

Low serum iron ferritin and hepcidin, but high TIBC

A

IDA

28
Q

Low serum iron and TIBC with increased serum ferritin

A

Anemia of Chronic Dz

29
Q

Pure red cell aplasia

A

Diamond Blackfan syndrome

30
Q

Pentad of symptoms for TTP

A 
Fever
Thrombocytopenia
MAHA
Neuro deficits
Renal failure
31
Q

ADAMTS13 mutation?

A

TTP

32
Q

Splenomegaly, increased buffy coat, mature myeloid cell proliferation?

A

CML

33
Q

occurs at all ages, >20% blasts in bone marrow, fever, fatigue, bleeding, may or may not have blasts in peripheral smear, 8:21 or 15:17

A

AML

34
Q

Auer rods

A

APL 15:17

35
Q

Reed sternberg cell markers?

A

CD15 CD30 Pax-5

36
Q

Rouleaux formation?

A

Hyperviscosity seen in hyperIg in Multiple Myeloma

37
Q

Epoetin alfa toxicities?

A

Increased risk of MI, death, stroke, VTE, tumor progressioni

38
Q

Hydroxyurea toxicities?

A

Neutropenia, oral ulcers, hyperpigmentation, mild GI upset

39
Q

Eculizumab toxicities?

A

viral infections, lie threatening meningococcal infections, immunogenic, URT infections, msk pain, anemia, leukopenia, htn, HA, insomnia/fatigue, UTI

40
Q

What does Eculizumab do?

A

Inhibitis terminal complement mediated intravascular hemolysis used in PNH, its only available under REMS

41
Q

Filgrastim toxicities? How/when to administer?

A

Bone pain, allergic reaction

IV infusion 24 hrs after chemo

42
Q

Sargramostim toxicities?

A

edema, sequestration of granulocytes in pulmonary circulation causing dyspnea, worsens existing renal and hepatic dysfunction, has benzyl alcohol causing fatal gasping syndrome in premies

43
Q

Oprelvekin toxicities?

A

significant edema, cardiac dysrhythmias, severe allergic rxn, blood shot eyes

44
Q

Romiplostim toxicities?

A

well tolerated most serious concern is allergic rxn

45
Q

Romiplostim pharmacokinetics?

A

weekly administration as a SC injection

46
Q

What drug is used in healthy individuals with thrombocytopenia or individuals with ITP after failure of glucocorticoids and immunoglobins?

A

Romiplostim

SBL 1 (8 decks)

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