Random stuff

Question 1

Which amino acid contributes atoms to the biosynthesis of both purines and pyrimidines?

Answer 1

Aspartate

Question 2

Which step is involved in the synthesis of thymine nucleotides?

Answer 2

dUMP -> dTMP

Question 3

Which of the following molecule is a substrate for the enzyme ribonucleotide reductase?

Answer 3

UDP

Question 4

What is true about methotrexate?

Answer 4

It inhibits dihydrofolate reductase enzyme

Question 5

Which enzyme is deficient in patients with hereditary orotic aciduria?

Answer 5

The UMP synthase complex that includes: orotate phosphoribosyl transferase and orotidylate decarboxylase

Question 6

“Guanine + PRPP -> GMP + PPi” represents a step in the…

Answer 6

Purine salvage pathway

Question 7

Which amino acids contribute atoms utilized in purine biosynthesis?

Answer 7

Asp, Gly, Gln

Question 8

Gout is characterized by high levels of ___, which forms crystal deposits of ___, resulting in painful joints

Answer 8

High levels of uric acid, crystal deposits of sodium urate

Question 9

Severe combined immunodeficiency syndrome (SCID) is caused by a deficiency of?

Answer 9

Adenosine deaminase (ADA)

Question 10

The synthesis of 5-phosphoribosylamine (PRA) from PRPP is controlled by:

Answer 10

Feed-forward activation