Random questions Flashcards
The following are more common in men, except. A. Hirschprung's disease B. Pyloric stenosis C. Meckel Diverticulum D. Esophageal mucosal webs
D.
Mutation in this gene is associated with familial cases and 15% of sporadic cases of Hirschprung’s disease.
RET
Which of the following immunohistochemical stains and special stains result confirms an aganglionic segment in Hirschprung’s disease?
A. Positive calretinin, positive acetylcholinesterase
B. Negative calretinin, negative acetylcholinesterase
C. Positive calretinin, negative acetylcholinesterase
D. Negative calretinin, positive acetylcholinesterase
D.
Remarks: Calret is negative and Ach is positive = confirms that there are no ganglion cells.
What is the most common site of GIT lymphoma?
Stomach
What is the most common site of GIT carcinoid tumor?
Small intestine (ileum and jejunum) Remarks: generally the second most common site of carcinoid tumor is the lungs and tracheobronchial tree.
What are the two risk factors in developing fundic gland polyp?
FAP and PPI’s
What is the most common cause of intestinal obstruction in children under age 2?
Intussusception
What is the syndrome that is associated with achalasia, alacrima and adrenal insufficiency?
Allgrove (triple A) syndrome
What is the triad of achalasia?
Incomplete relaxation of LES
Increased tone of LES
Aperistalsis
“IRITA”
What is the characteristic of the esophageal ulcer in Herpes virus infection?
Punched out ulcer
Remarks: CMV has shallow ulcers.
What are the histologic features of reflux esophagitis?
Eosinophils in the squamous mucosa
Neutrophils- in more severe cases
Basal zone hyperplasia of more than 20%
Abnormal squamous maturation
What is the definition of short segment and long segment Barrett esophagus?
Short segment - less than 3 cm
Long segment - more than or equal to 3cm
The following are true of esophageal squamous cell, except.
A. It is associated with amplification of SOX2
B. Risk factors include drinking of hot beverages and poverty
C. It is nearly eight-fold more common in Caucasians
D. It is more common in males, usually at ages older than 45
C.
Remarks: It is more common in African Americans than caucasians. It is very common in Kenya because of the drink mursik (fermented milk).
This condition is caused by a submucosal artery that does not branch properly causing erosion and gastric bleeding.
Dieulafoy lesion
This disease is otherwise known as the “watermelon stomach”.
Gastric antral vascular ectasia (GAVE) - it is responsible for a minority of non-variceal upper GI bleeding.