RANDOM/ PRODIGY TRIVIA/VALLEY BOOK 2 Flashcards

1
Q

Where is the DORSAL RESPIRATORY GROUP located

A

Medulla

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2
Q

Ventral Respiratory Group can influence both

A

Inspiratory and expiratory

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3
Q

Pneumotaxic located in (thinkPP)

A

PONS

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4
Q

Pneumotaxic center now called

A

PRG (Pontine Respiratory GROUP)

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5
Q

Peripheral chemoreceptors are found MOSTLY in the

A

Carotid bodies but also in aortic bodies

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6
Q

Peripheral chemoreceptors responds to

A

Decreased PaO2 < 60 mmHg
Increased H+ (low pH)
increased PaCO2

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7
Q

Peripheral chemoreceptors ARE MOST RESPONSIVE TO

A

Decrease in arterial blood O2, when PaO2, falls below 60mmHg

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8
Q

The glossopharyngeal nerve carries afferent information from the

A

CAROTID BODIES

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9
Q

VAGUS nerve carries afferent information from the

A

AORITC BODIES and LUNG STRETCH receptors

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10
Q

Central chemoreceptors response to

A

Hydrogen ions

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11
Q

WHat normally drives Co2

A

VENTILATON

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12
Q

The pleural membranes couple the

A

Lungs to the chest wall

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13
Q

What is intrapleural pressure

A

The pressure in the space between the inside of the chest wall and the lungs

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14
Q

Intrapleural pressure is always

A

NEGATIVE (subatmospheric) during normal Tidal breathing.

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15
Q

Intrapleural pressure becomes more negative during ______and more less negative during

A

during inspiration; Expiration

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16
Q

Intrapulmonary pressure is ______during inspiration and______during expiration .

A

negative, positive

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17
Q

When does INTRAPLEURAL PRESSURE BECOMES POSITIVE

A

Forced expiration OR during exp effort against a closed glottis, such as the Valsava maneuver.

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18
Q

1 atm = ____mmhg = _____cm H2O

A

760; 1033 cm H2O

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19
Q

MV is normally____

A

4Lmin

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20
Q

CO is normally

A

5L min

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21
Q

The average V/Q for the lungs is

A

0.8

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22
Q

In the upright position, the dependent lung is at the

A

Base

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23
Q

In the upright position, the nondependent lung is at the

A

APEX

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24
Q

When the patient in the lateral decubitus position is anesthesized and paralyzed what occurs

A

a V/Q mismatch develops, ventilation is the non-dependent lung increases (because the dependent lung is difficult to insufflate) but the distribution of blood flow does not changes, compared to the awake, spontaneously breathing patient.

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25
Always decreases whenever there is a V/Q mismatch
PaO2
26
The decrease in PaO2 seen with V/Q mismatch may be accompanied with
Hypocapnia, Normocapnia Hypercapnia
27
A-A gradient change with age
PAO2 - PaO2 = 0.21 x (age + 2.5)
28
Estimating PaO2
Multiple percent O2 in the inspirate gas mixture by 5 ( EX: 0.6 FiO2 is 60 x 5 = 300mmhg
29
Estimating PAO2
Multiple percent O2 in the inspirate gas mixture by 5
30
When V/Q is 0 there is
ABSOLUTE right to Left shunt
31
Normal PAO2 - PaO2 when breathing room air
5-15 mmHg
32
Normal PAO2 - PaO2 when 100 % O2
100 mmHg
33
Do you CPAP the dependent or nondependent lung
the NONDEPENDENT
34
Do you PEEP the dependent or nondependent lung
DEPENDENT
35
Most effective intervention for the NONdependent lung
CPAP
36
West zone describe _______in the lung
PERFUSION
37
West zone are not
Anatomically fixed zones, they are variable, functional zones, dependent upon body position
38
Compared with zone 1, zone 3 is
Better ventilated, better perfused has a lower V/Q ratio
39
Zone 1 vs Zone 3 negative intrapleural pressure
less negative intrapleural pressure
40
Zone 1 vs Zone 3 size alveoli
Zone 3 smaller alveoli
41
The zone 4 lung requires
4th pressure, P interstitial fluid
42
Zone1, 2, 3 , 4
Zone 1: PA>Pa.Pv Zone 2: Pa> PA>Pv Zone 3: Pa> Pv> PA Zone 4: Pa>Pisf>Pv> PA
43
Zone 4 mnemonic
aiVA
44
The patient is preoxygenated to
Fill the FRC with O2,
45
What is oxygen consumption
250 ml O2/min
46
Found in the FRC
2500 ml so divided by 250 per min, you have 10 minutes
47
In response to alveolar hypoxia, The alveolar arterioles constrict
thereby decreasing shunt blood flow
48
When does VA inhibit HPV
>1 MAC
49
Cannot be measured by spirometry
FRC, RV and TLC
50
Ratio that is useful in distinguishing between restrictive and obstructive disease
FEV1/FRC
51
What is the best lung volume test for assessing for small airway disease>
FEF 25-75 (MMEF) MidMaximal expiratory flow
52
Normal FEV1/FVC
4 L / 5 L =0.8 FEV1/FVC ratio
53
Obstructive FEV1/FVC Examples
FEV1 = 1.3 L/ FVC 3.1 | FEV1/FRC ratio is 0.42 (42%)
54
Obstructive disease is present when
Both FEV1 and FVC are low
55
What is the Normal FEV1/FVC ratio
> 0.7
56
Restrictive disease is present when
both FEV1 and FVC are LOW but the RATION is equal or greater than 0.7
57
For restrictive and obstructive disease always calculate
the FEV1/FRC ratio
58
Criteria to cancel case FEV1 and FEV1/FRC ratio
If FEV1 < 2L and FEV1/FRC ratio < 50% more sophisticated lung fuction tests are needed.
59
Restricted loop are associated with
smaller volume
60
Intrapleural pressure increases with
FORCED VITAL EXPIRATION or VALSAVA maneuvers.
61
During forced expiration , intrapleural pressure becomes
Positive
62
AS liquid flow through a tube, the pressure Increases or decreases
DECREASES (falls)
63
In the airway pressure
decreases, as gas flow along the bronchioles. THIS IS THE PHYSICAL BASES or airway closure.
64
US 65-45
Upright closing capacity = FRC upright at 65 | Sitting -----------------------= --------- sitting at 45
65
Lung compliance with aging
INCREASES
66
FRC with aginst
Increases
67
Except for the cricothyroid muscle, the instrinsic muscles of the larynx are innervated by WHAT MOTOR NERVE/
RLN
68
Oxyhemoglobin curve becomes steep when PaO2 falls below
60 mmhg
69
The patient is given meperidine for premedication , what happens to the oxyhemoglobin dissociation curve and the Co2 Blood dissociation curve?
Oxyhgb curve to the right | CO2 shifts left
70
What is the PaO2 when the SaO2 is 90%?
Think 40-90 rule 40mmHg - 70% SPO2 50mmHg - 80% SPO2 60mmHg - 90% SPO2
71
What % of Co2 is carried in the blood as bicarbonate?
90%
72
What enzyme (s) is (are) responsible for producing Bicarbonate in the rbc?
Carbonic Anhydrase
73
If PaCo2 is 30 mmhg how much Co2 is dissolved in blood . Give answer to 2 decimal places
30 x 0.067 = 2.01 mL
74
Peripheral chemoreceptors are most sensitive to
Decreased PaO2 (< 60 mmHg )
75
What nerve carries sensory information from the carotid and what nerve carries sensory information from the aortic bodies?
Carotid - Glossopharyngeal | Aortic - VAVUS
76
What nerve carries sensory information from the carotid and what nerve carries sensory information from the aortic bodies?
Carotid - Glossopharyngeal Aortic - VAVUS CGAV
77
Where are ventilation and perfusion greatest in the normal healthy lung in the awake individuals?
Ventilation greatest in the Dependent lung | Perfusion greatest in the DEPENDENT lung
78
Compare PACO2 in the base with PACO2 in the apex when the patient is in the prone position?
PACO2 is the same in the base of the supplies
79
Compared with non-dependent lung each of the following is greater in dependent lung, except:
ALVEOLAR DIAMETER
80
Compared with non-dependent lung each of the following is greater in dependent lung
Ventilation Perfusion PACO2
81
A patient breathing room air has a PaO2 of 45 mmHg , a PAO2 of 80 mmhg and a PaCO2 of 75 mmHg what is the problem?
There is a Ventilation;perfusion abnormality.
82
What is the problem if the patient has a segment of the lung with a ventilation:perfusion ratio of zero?
Patient has a RIGHT to LEFT SHUNT
83
The patient's spirometric recordings reveal an FEV1 of 2L and an FVC of 4 L that values indicates
Obstructive disease (ratio is 50%)
84
For obstruction loop : top is _________ and bottom is _______
Expiratory bottom is Inspiratory (it's flipped compared to volume capacity graph)
85
To remember if the APEX triangle points more toward EXPIRTORY it
Extrathoracic obstruction
86
What happens to pulmonary (lung) compliance and chest wall compliance as you age?
Pulmonary compliance increase | Chest wall compliance decrease
87
Vd is
Theoretical volume, Drug in body / concentration in plasma
88
Clearance (Cl) is
Theoretical volume of plasma completed cleared of drug in a given period of time.
89
Elimination half life vs elimination half time
half life --> time it takes for the total amount of drug, in the body to decrease by one half. elimination half time --> plasma concentration of a drug to fall by one-half.
90
What the BODY does to the drug
PharmacoKINETICS
91
Time is
CONCENTRATION
92
Life is
AMOUNT
93
TCLA
Time-->concentration | Life --> Amount
94
Constant amount of drug eliminated per unit of time
Zero Order kinetics
95
Drugs that undergo zero order kinteics
Phenytoin, Alcohol, ASA
96
When the plasma concentration of any drugs exceeds the capacity of metabolizing enzymes
Zero Order kinteics.
97
First order kinetics (think FF)
CONSTANT FRACTION
98
Alpha phase is
Distribution
99
bEta phase is
ELIMINATION (B-e)
100
T 1/2 B (half time Beta) =
0.693 Vd/ Cl
101
How many half lives are required to eliminates at LEAST 98% of a drug?
6
102
Type I phase reaction
Oxidation Reduction Hydrolysis Methylation
103
What is the important pathway of metabolism for PROCAINAMIDE , hydralazine and isoniazid
ACETYLATION
104
Acid better absorbed in
Acidic
105
Basic better absorbed in
Basic
106
For acid , if pH < pka = | if pH > pKa =
Nonionized | IONIZED
107
For basic, if pH< Pka= | if pH>pKa
Ionized | Nonionized
108
ANother way to say that a substance has accepted a hYDROGEN H+ ion is to say that the susbtance in
PROTONATED>
109
What combination will most facilitate trapping of LA by the fetus?
Maternal alkalosis AND fetal acidosis
110
What combination will most PREVENT PASSAGE of LA to the UTERUS
Fetal ACIDOSIS
111
Weak acids and weak bases are provided in solution as
SALTS
112
Weak acids name has the
Cation first (calcium..., mag this, sodium this)
113
Weak bases name has the
anion last (drug chloride, drug sulfate)
114
Propofol is a (weak acid or weak base)
WEAK ACID
115
Propofol in physiologic ph
99.98 % nonionized.
116
All LAs are
Weak bases
117
Base + acid
MORE IONIZED
118
In general the lower the pKa of the local anesthetic, the_____the proportion of LA in ______form
GREATER the proportion of LA in NONIONIZED form at physiologic pH of 7.4 and FASTER ONSET OF BLOC
119
Potency of LA is based on
LIPID solubility (SLP)
120
>90 % protein binding La
Ropivacaine 94% | Bupivacaine 95%
121
The duration of ACTION is longer for LA that exhibit ______protein and _______lipid solubility
GREATEST PROTEIN BINDING and HIGHEST LIPID SOLUBILITY
122
More important than lipid solubility when it comes to duration of action
PROTEIN BINDING
123
LA absorption : generally
the greater the tissue blood flow, the greater the rate of absorption
124
Mnemonic to remember absorptbion
IvTicPEBSubAC IV -->Tracheal -->Intercostal---> Paracervical --> Epidural --> Brachial plexus --> Subarachonid,sciatic fem -->Subcutaneous.
125
Sympathetic block compared to sensory block
2-6 dermatomes HIGHER than sensory block
126
MOTOR block compared to sensory block
2 dermatomes lower than sensory bloc
127
For myelinated axons, _____nodes of Ranvier must be blocked to stop nerve conduction
2-3 nodes
128
The greater the frequency of action potentials, the
Faster the nerve is blocked, by local anesthetic
129
The LA must attach to the sodium channel when it is in the
INACTIVATED STATE
130
Both required to a conduciton block
Both nonionized, and ionized forms of LA the nonionized cross the lipid bilary the ionized form attaches to the inside of sodium channel and LOCKS it shut in the INACTIVATED STATE
131
Key target of LA is the
Voltage-gated sodium channels.
132
LA degree of blockade depends on both
Concentration and volume.
133
Max dose of bupivacaine w/ EPI
2.5 mg/kg
134
Max dose of bupivacaine w/O EPI
2mg/kg
135
Max single dose of Bupivacaine
175 mg
136
Max single dose LIDOCAINE
300 mg
137
Max single dose of ROPIVACAINE
200
138
Max dose of Lidocaine w/o epinephrine is
4.5 mg/kg
139
Max dose of Lidocaine w/ epinephrine is
7mg/kg
140
Ropivacaine dose per kg
3 mg/kg
141
Lidocaine plasma concentration 1-5 mcg/ml
Analgesia therapeutic
142
What is the therapeutic lidocaine plasma concentration?
1-5 mcg/ml
143
Lidocaine plasma concentration 5-10 mcg/ml
``` Light headedness Tinnitus Visual disturbances' Tongue numbness Muscle twitching ```
144
The recommended maximum leakage current allowed in operating room equipment is:
10 μA
145
Lidocaine plasma concentration 10-15 mcg/ml
Seizures | Convulsions
146
Lidocaine plasma concentration 15-25 mcg/ml
Unconsciousness Coma Respiratory arrest
147
Lidocaine plasma concentration >25 mcg/ml
Cardiovascular depression
148
Drug will be eliminated slowly it is back
Clearance is small and Vd is large
149
Potency is directly related to
Lipid solubility
150
MAC to potency
INVERSELY related to potency
151
Oil gas partition coefficeints
NDSIEH (nitrous, des, sevo, iso, enflu, halothane) | 1.4, 18, 55, 98,98, 224
152
Greatest sensitization to catecholamines occur with
Halothane.
153
Oil gas partition coefficients is a measure of
LIPID SOLUBILITY
154
Decrease CO induction is
FAST
155
Increase CO induction is
SLOW
156
Sevoflurane decrease arterial BP and SVR vs des/iso
Greater decrease with des and iso than sevo
157
Solubility of a gas and temperature
Inverse relationship | as temperature increases, solubility decreases
158
More inhlational agent will dissolve in blood if the patient is
HYPOTHERMIC
159
More inhlational agent will dissolve in blood if the patient is HYPOTHERMIC , what explains this phenomenon
Le Chatelier's principle.
160
Blood/ Gas coefficient HIGH to low
``` HIS ND Halothane 2.54 Isoflurane 1.46 Sevoflurane 0.69 Nitrous oxide 0.46 Desflurane 0.42 ```
161
Alveoli are
WINDOWS TO THE BRAIN
162
Speed of uptake of anesthetic and elimination from the brain is________ related to blood solubility
INVERSELY RELATED
163
Mirror the brain partial pressure at steady state.
Alveolar partial pressure of the anesthetic
164
The CNS effects after bolus injection of an IV anesthetic are terminated primarily by
REDISTRIBUTION
165
Diazepam and protein binding
98%
166
2 that ketamine causes
nystagmus | Hypertonous
167
IV anesthetic with bronchodilation properties
Ketamine
168
Meperidine to morphine potency
1/10th
169
Meperidine metabolite
Normeperidine
170
Phenylpiperidine derivative
Fentanyl, meperidine
171
Fentanyl to morphine potency
Fentanyl 75-125x more potent
172
Fentanyl what organ serve as inactive storage site?
LUNGS with 75% of the INITIAL DOSE UNDERGOING FIRST PASS PULMONARY UPTAKE.
173
Meperidine crosses placenta
YES ALL OPIOIDS DO
174
Thienyl analogue of fentanyl
Sufentanil
175
Sufentanil potency
5-10x more than fentanyl
176
Alfentanil potency
1/5 to 1/10 less potent than fentanyl
177
VP pressure measure at
20C
178
VP pressure of gases: HIGH to low (DHIES)
``` Desflurane Halothane Isoflurane Enflurane Sevoflurane ```
179
VP pressure of gases: Des (mmHg)
669
180
VP pressure of gases: Halothane
244
181
VP pressure of gases: Isoflurane
240
182
VP pressure of gases: Enflurane
172
183
VP pressure of gases: Sevo
157 -170
184
Vapor pressure and output MNEMONIC (HLH)
Higher vapor pressure agent PLACED in a vaporizer with LOWER vapor pressure agent , the concentration of agent delivered to the patient will be HIGHER than the dial setting
185
Vapor pressure and output MNEMONIC (LHL)
Lower vapor pressure agent placed in a vaporizer with HIGHER vapor pressure agent, the concentration of agent delivered to the patient will be LOWER than the dial setting.
186
The partial pressure of saturated water vapor at 37C is
47 mmHg
187
Law of LAPLACE
T = (P x r) /2
188
Law that. applied to blood vessels
Law of Laplace
189
LAW of laplace explains why smaller alveoli empty into
LARGE ALVEOLI causing atelectasis in patients with ARDS
190
POISEUILLE"S law
Q = Pi r^4 Change in P/ 8 n L
191
Diffusion hypoxia explains by which law
GRAHAM's
192
Boyles is the
VP (Volume/Pressure relationship)
193
Charles goes into
Vtach (Volume to Temperature)
194
Gay Lussac's law is the
PT (pressure to Temp)
195
Is uterine blood flow autoregulated
NO
196
TI =
TD50/ED 50
197
What is the number that shows how much a gas will dissolve in a liquid at a certain temperature?
OSTWALD.
198
A principle for calculating CO from oxygen uptake or CO elimination and Oxygen or CO2 concentration in arterial and venous blood
Fick principle
199
Describe behavior of non-ideal gases
Van der waal
200
Gas pressure is inversely proportion to gas volume at constant Temperature?
Boyle's
201
Total pressure of a mixture of gases is equal to the sum of all partial pressure
DALTON"s
202
6.02 x 10 ^23
AVOGADRO
203
Gas pressure increase if temperature increases and volume does not change.
Gay-lussac
204
One mole of ideal gas occupies 22. 4 L at 0C and 1 atm
Avogadro
205
Law": Volume increases when temperature increases , if pressure is constant
Charles
206
Twice as much O2 will dissolve in arterial blood if alveolar pressure of O2 is doubled
HENRY's LAW
207
if alveolar pressure of O2 is doubled, how much O2 will dissove
twice as much
208
Number revealing laminar vs turbulent flow
Reynolds
209
Concentration effect which law
FICK's law of diffusion
210
Explained how pressure, tube radius, length and fluid viscosity contribute to laminar flow
Hagen-Poiseuille law
211
Tension in the wall of blood vessel is_______ to the radius
PROPORTIONAL
212
Tension in the wall of blood vessel is proportional to the radius which law
Laplace
213
The lateral pressure of fluid flowing through a CONSTRICTED SEGMENT of tubing is decrease
Bernoulli principe
214
What law explains normal tidal breathing?
Boyles'
215
Muscle relaxants are what kind of compounds
Quarternary ammonium
216
Desflurane, enflurane isoflurane and sevoflurane are
halogenated ETHERS
217
SVR = MAP - CVP/CO x80 which law permits this calculation
OHM's LAW
218
Salt form or a weak acid naming examples
Sodium "drug" example
219
If ph of stomach is 2.0 which orally admininstered drug will be most NONIONIZED
A weak acid with pKa 6.2
220
A local anesthetics is a
WEAK BASE with a PKA greater than 7.4
221
4-8 mesh soda lime prevents
Channeling while providing an adequate surface area for CO2 absorption.
222
What is the partial pressure of a gas if its concentration is 5%?
38 mmHg (760 mmHg x 5/ 100)
223
If a gas exerts a partial pressure of 15 mmHg its concentration is ____%
2.0 % (1.97 % to be exact) set up proportion 760mmHg/100% = 15 mmHg/ x
224
In the reaction of CO2 with soda lime the final producs are
CARBONATES
225
Which pulmonary function test uses boyle's law?
Plethysmotraphy for determination of FRC
226
THE GENERATION OF colloid osmotic pressure in the plasma is the principle function of
Albumin
227
A 3% stock solution of drug is available. You need to make 50 ml of a 0.6 mg/ml solution. How many mL will you take from stock solution to make the dilute solution
1ml 0.6 mg = 1 ml for 50 ml you need 30 mg 3% solution is 30 mg/ml
228
Sevoflurane is added to a flask sitting on a table, what is the concentration of sevoflurane above the liquid?
22%
229
The lipid bilayer of the cell membrane is most IMPERMEABLE to what
Charged ion such as Potassium ions
230
Between gases not including Nitrous which one has the lowest Blood gas coefficient
Desflurane
231
What is the relative humidity of alveolar gas?
100%
232
When the tank pressure gauge on a tank of N2O begins to fall, the tank
NO LONGER CONTAINS N2O liquid form
233
The rotator flowmeter is an example of
Variable orifice flowmeter
234
An agent with a Blood gas partition of 12 an an oil gas partition coefficient of 0.5 builds up ______and ____potency
Slowly; and lacks potency
235
Substance that most readily cross the placenta or blood/brain barrier?
highly lipid soluble, NONIONIZED
236
Lowest oil:gas partition coefficient
Desflurane
237
Immediately after onset of 50% N2O administration, the volume of the stomach may
Increase
238
If flow is laminar and the radius of a tube is tripled , the flow through the tube will increase
``` 81 fold HOw: Lets assume to radius you started with was 2 so r^4 of 2 is 16 Now: radius tripled (2 x3 =6 ) so r^4 of 6 is 1296 ``` When you divide 1296 / 16 = 81
239
What can be measured with a wright respirometer?
Tidal Volume
240
1: 500,000 concentration is _____mcg/ml
2 mcg/ml. (remember all ratio divide 1,000,000 by the :xxxxxxx )
241
What property of helium makes it a useful agent?
LOW DENSITY (makes flow more laminar)
242
When halothane is added to a flask containing 100% O2, the new concentration of O2 will be
68% How: use VP of desflurane which is 244 mmHg /760 mmHg x 100 % = 32% 100%-32% = 68% for O2
243
The cylinder of N2O cools after it is turned on , what explains this cooling?
Joule-Thompson effect
244
Tension in the blood vessel wall will be lowest in the
Capillary
245
During diastole, the tension in the LV wall increases, what explains this
Law of laplace
246
When you put an ETT in an autoclave, the cuff expans, this is an application of
Charles LAW
247
When the length of an IV needle is doubled, what happens to flow from the IV bag, and what law applies?
Flow is halved, Hagen-poiseuilles' law applies
248
How much Co2 is dissolved in arterial blood when PaCo2 is 70 mmHg
4.69 mL CO2/ 100 mL blood
249
When is the partial pressure of CO2 increases, more hydrogen ions and bicarbonate ions are produced: Which law or principle applies?
Le Chatelier's principle
250
The reaction of CO2 with soda lime is a
NEUTRALIZATION
251
What is the concentration of a solution in % if 250mg is added to 50ml of water?
250/50 = 5 mg/ml ``` the way i do it I know 2% lidocaine is 20 mg /ml 2 % = 20 mg/ml x = 5 mg/ml (5 x2) / 20 = 0.5% ```
252
Soda lime greatest concentration is
Calcium Hydroxide Ca(OH)2
253
Which law explains atelectasis with patient with ARDS
LAPLACE
254
If MAP is 100mmHg , CVP is 10mmHg, CO is 4.5L/min , the resistance to flow through the Systemic circulation in dynes-cm^-5 is
1600 | Formula is : MAP-CVP/CO x 80
255
When flow is turbulent, the resistance to flow is dependent on what property of the fluid?
DENSITY
256
What important changes occurs when laminar flow changes to turbulent flow?
Resistance increases
257
Carbonic anhydrase inhibitors decrease the ability of the kidneys to reabsorb bicarbonate, resulting a
hyperchloremic acidosis.
258
Carbonic anhydrase inhibitors would be avoided in patients with
acidosis, especially a normal-anionic-gap acidosis
259
As a result, because bicarbonate is filtered by the ciliary process in the formation of aqueous humor,
carbonic anhydrase inhibitors reduce the formation of aqueous humor and can be used to decrease intraocular pressure
260
Bicarbonate is filtered by the
ciliary process in the formation of aqueous humor,
261
A bourdon gauge reads 100 psi, what is the pressure inside the cylinder ? 1 atm= 14.5 psi
114.5 psi. (it is the pressure GAUGE reading + 14.5)
262
If your tire gauge reads 34 psi (pounds per square inch), then the absolute pressure is
34 psi plus 14.7 psi = 48.7
263
2 bubbles, one with a radius of 2mm called P(s) and the other one with a radius of 4mm P (L) how does the pressure inside the large bubble compared to the pressure inside the small bubble (Ps)
The pressure of the large bubble is half the pressure of the small bubble
264
VP from Low to HIGH (SEI-HD) | 170-172-240-244-669
``` Sevoflurane, 170 mmHg Enflurane, 172 mmHg Isoflurane, 240 mmHg Halothane, 244 mmHg Desflurane, 669 mmHg ```
265
What happens to alveoli that do not have surfactant?
Smaller alveoli collapse into larger ones.
266
Parameters used to calculate reynold's number ?
Velocity of the fluid Viscosity Diameter of the tube
267
With laminar flow the gas flow rate is
directly proportional to the pressure gradient along the tube
268
Nebulizers use
venturi tubes
269
As an E-cylinder of oxygen empties, ice crystals form near the outlet, this is explained by what?
Joule-Thompson
270
What explains why opening a cylinder slower , allow the expanding gas to draw energy from the environment to maintain an equal distribution of energy, we observe no changes in temperature of the gas
2nd law of Thermodynamics (Entropy)
271
Rapid expansion of a gas causes the temperature to ________as explains by the ______Effect
decrease ; Joule-Thompson Effect
272
Reynolds number formula is
Vpd/n v: velocity d: diameter p density
273
When sevoflurane is accidentally placed in a halothane vaporizer and the dial is set a 1% , the % delivered will be
less than 2%
274
What volume will be occupied by 16 g (half a mole) of O2 at standard temperature and pressure (Assume o2 is an ideal gas?
11.2 ( Full mole at STP is 22.4)
275
When Nitrous is turned on, gas bubbles in the body expand, what law applies?
Fick's Law of diffusion
276
What is the partial pressure of isoflurane when the concentration delivered to the patient is 1.5%?
760 mmHg x 1.5% = 11.4 mmHg
277
The desflurane vaporizer is electrically heated to _______which creates a vapor pressure of ________inside the vaporizer, regardless of ambient pressure
39 degrees centigrade, 2 atmospheres
278
For desflurane, The number on the dial reflects the percentage that will be delivered. So at any altitude, when you dial 5%, it will give you _______ But when that 5% desflurane leaves the vaporizer at high altitude, what happens?
It will give you 5%; is delivered to the patient is 5% of a decreased ambient pressure, so the partial pressure of desflurane in the alveoli will be much less that it would be at sea level. Thus, you will need to dial a higher concentration at high elevation to attain the same clinical effect as at sea level with desflurane (Tec-9) vaporizer.
279
If desflurane is HIGH ALTITUDE, when you dial 5%, the vaporizer will give you______%. The partial pressure delivered will be ______
5% , the
280
Desflurane at HIGH altitude
dial a HIGHER concentration at HIGHER elevation to attain the same clinical effect ,
281
For gases, What is physiologically important is the
partial pressure (mm Hg), not the concentration.
282
What determines whether a patient is anesthetized,
The partial pressure of the anesthetic agent
283
Does the partial pressure of the anesthetic change with altitude?
Does not change at different altitudes.
284
At a higher altitude where the barometric pressure is _______of that at sea level. The amount of isoflurane Vapor output ______due to ______barometric pressure.
½ that at sea level, the amount of isoflurane vapor output increases due to the lower barometric pressure. Therefore, the settings that delivered 2% isoflurane now deliver 4% isoflurane. However, according to Dalton’s law, the partial pressure of isoflurane delivered would be approximately the same at both altitudes since 2% isoflurane at 760mm Hg (15.2 mm Hg) is the same as 4% isoflurane at 380mm Hg (15.2 mm Hg).
285
What conditions will optimize the amount of gas dissolved in a liquid?
INCREASED PARIAL PRESSURE | DECREASED TEMPERATURE
286
The buildup of an inhalational anesthetic in the brain is fastest for an agent that has
Low blood solubility
287
The most potent inhalational anesthetics have
HIGH lipid solubility
288
If the Ostwald blood: gas partition coefficient is 2, then each liter of blood will have as many molecules as one liter of alveolar gas?
TWICE
289
If the partial pressure of a gas over a liquid doubles, the amount of gas dissolved in the liquid
DOUBLES
290
Henry's law
gas law that states that the amount of dissolved gas in a liquid is proportional to its partial pressure above the liquid. The proportionality factor is called Henry's law constant.
291
Which gas can be liquified at room temperature?
Nitrous oxide
292
When a gas cylinder connected to an anesthetic machine is turned on quickly and the pressure in the connecting pipes and gauges rises rapidly, the process is
ADIABATIC and temperature increases substantially
293
What is Adiabatic changes?
Rapid expansion OR compression of a gas WITHOUT equillibration of energy with the surrounding environment NO increase or decrease in energy. BUT THE TEMPERATURE WILL BE HIGHER
294
Medical air at atmospheric pressure is composed of _____and _____? what are the partial pressures and how are they calculated ?
Nitrogen and Oxygen 79% x 760 mmHg = 600.4mmHg 21% x 760mm Hg= 159.6 mmHg
295
Which inhalational anesthetic has a blood:gas partition coefficient of 1.4?
Isoflurane
296
Recovery from which of the following inhalational agents will be fastest?
Desflurane
297
What happens to pressure in the middle ear when the N2O is turned off?
It decreases
298
Substance "X" will diffuse at a faster rate across the alveolar-capillary wall than substance "Y" if substance " X is more _________
Lipid soluble
299
The rate of diffusion of a gas accross the alveolar capillary membrane is inversely proportional to the
THICKNESS OF THE MEMBRANE
300
The factors that determine the amount of gas diffusing across the alveolar capillary membrane are described by
FICK's LAW
301
Which of the following substances does not penetrate the BBB?
Mannitol
302
Graham's law
Rate of effusion of a gas is INVERSELY PROPORTIONAL To the square root of its molecular weight.
303
N2 and N2O are diffusing through the air (not across a membrane). N2 will diffuse fast than N2O. Whose law applies>
GRAHAM's LAW
304
IV infusion of which of the following substances would be most effective in promoting the osmotic movement of water into the circulation from the extracellular space>
ALbumin
305
The pressure in a cylinder of O2 decreases at it empties, what law applies?
IDEAL
306
When a full E-cylinder of Oxygen is brought from the loading dock where the temperature is 40C to the OR where the temperature is set at 21C. the pressure in the cylinder will increase or decrease, whose law applies?
pressure will decrease, GAY lussacs law (P1/T1 = P2/T2)
307
Helium/oxygen mixture are used medically for
UPPER AIRWAY OBSTRUCTION
308
What is the water vapor pressure in the alveoli?
47 mmHg
309
The clinically significant different between N2 and N2O is their
BLOOD SOLUBILITIES
310
When the partial pressure of O2 in arterial blood increase from 100 to 600mmHg the amount of dissolved O2 increases BY how much.?
100 x 0.003 = 0.3 600 x 0.003 = 1.8 1.8 - 0.3 = 1.5 mL O2/100ml blood
311
What 2 parameters are used to calculate RESISTANCE to flow through a tube?
UM NOT SURE That's the right answer (PRESSURE and gradient) per valley
312
In venturi tube, the lateral pressure upstream from the narrowing is
GREATER than in the narrowed region
313
High temperature may be generated when empty cylinders are
Transfilled from larger cylinders
314
High temperature may be generated when empty cylinders are Transfilled from larger cylinders . This is called the
ADIABATIC EFFECT
315
The Joule-Thompson effect describes the decrease in temperature when a
Gas exiting a compressed cylinder expands freely
316
Soda lime consists of silica, water
Sodium hydroxide Potassium hydroxide Calcium hydroxide
317
What law permits calculation of resistance to flow through at tube?
Omh's LAW
318
If isoflurane is placed in an enflurane vaporizer and the dial is set at 2% what will be the delivered concentration of isoflurane?
Greater than 2%
319
The Jet ventilator operates on
Le chatelier's principle
320
A mechanism used to reduce the pressure of a gas as it rises from a compressed gas cylinder to a usable, nearly constant pressure is a.
REGULATOR
321
The greater the distance between an Xray source and the anesthetist , the lower the intensity of exposure tot the xrays. The law describing this is the
INVERSE SQUARE LAW
322
The density of a gas determines
ITS FLOW THROUGH an ORIFICE
323
In the supine individual, the pressure in the dorsalis pedis is greater than in the aorta. This is explained by
The SUPERIMPOSITION PRINCIPLE
324
Which of the following principles is utilized in the delivery of a gas through a side arm port?
Bernoulli's
325
The partial pressure of Oxygen in air at one atmosphere is
159mmHg
326
The mass spectometer is reading 5% for ETCO2, what is approximate equivalent in mmHg?
38 mmHg (0.05x760)
327
Lipid bilayer is made up of
Cholesterol Phospholipids Proteins Symmetrical
328
Competitive antagonists attach to receptors and
Prevents attachment of agonists
329
Flow is 5L/min, (2.5L /min O2, and 2.5L/min of N2O) through a copper kettle vaporizer, and a 2% concentration of halothane is achieved. If N2o runs out, the halothane concentration delivered to the patient will be?
4%
330
If halothane is added to a flask sitting on a lab bench containing 100% O2, what will be the resulting partial pressure of O2 in the gas above the halothane liquid?
760mmhg-243 (halothane) =517
331
If isoflurane is placed in an enflurane and you set the dial at 2% what will happen the % of anesthetic delivered?
A higher concentration of isoflurane will be delivered than the 2% dialed in (HLH)
332
Purity of gases
Pharmacopeia + National formulary
333
O2 has a critical temperature _____room temperature
BELOW
334
Standards for medical devices and gases set by
FDA
335
Sets basic performance and SAFETY REQUIREMENTS for components of anesthesia machines, endotracheal tubes, and connections, pressure and vaccum and gas pressure regulators
American National Standards Institutes (ANSI)(
336
Each cylinder test by interior hydrostatic pressure once every
5 years
337
ALl cylinders must be marked according to
Interstate commerce commissions regulations.
338
The cylinder should be open slightly for a moment to
clear the outlet of possible dust. CRACKING the cylinder
339
Can generate heat and cause combustion with cylinder
ADIABATIC heat of compression.
340
The cylinder safety device is a simple plus of
SOFT METAL ALLOY called WOOD's metal,
341
At what temperature would the wood's metal melt
200F
342
Prevents cylinder gas from escaping machine through pipeline supply hoses?
Check valve in DISS
343
Check valve in pipeline inlet assembly is a
Floating valve and seats according to pressure.
344
What is the name of the gauge that shows Oxygen tank pressure?
Bourdon
345
In a dual hanger yoke system, what prevents one cylinder from emptying into the other?
There is a free-floating valve for each cylinder and the Oxygen E cylinder with the greater pressure closes the free-floating valve of the other
346
The 1st and 2nd stage regulator are what kind of valve
DIAPHRAGM
347
1st stage regular decrease pressure to
45psig
348
Cylinder vs pipeline pressure
Cylinder pressure decreased to slighly less than pipeline pressure to prevent depletion of cylinder contents when attached to pipeline.
349
2nd stage regulator
Reduces pressure from 50psig to 16
350
Oxygen flush valve flow rate____at what pressure ___
35-75 ml/min; 50 psig
351
Oxygen failure cut off valve, where do O2 and N2O mix
They don't mix
352
Gases are joined for the first time in the
COMMON MANIFOLD
353
Oxygen failure cutoff valve : oxygen pressure must be maintain at least
25 psig to keep valve open
354
Fail safe systems analyze O2 pipeline content?
NO they only analyze pressure.
355
Does the fail-safe protect from cross over pipeline
NO
356
Read ball float at the
middle
357
Thorpe tube largest at the
TOP
358
What happens if inspiratory valve sticks open?
Exp volume will exhaust through the insp limb. ETCO2 waveform will be elevated.
359
What happens if expiratory valve sticks open?
Insp volume will not enter the ETT but instead will bypass and exhaust through the exp limb.
360
Desflurane boils at
22.8C.
361
What happen when the vaporizer is tipped then leveled?
Liquid vapor will get into the VAPORIZER CHAMBER and the carrier flow will carry MORE AGENT to the patient
362
What happen when the vaporizer is tipped then leveled?
Liquid vapor will get into the VAPORIZER CHAMBER and the carrier flow will carry MORE AGENT to the patient. MORE AGENT picked up means HIGHER CONCENTRATION of agent delivered to the patient. It may be a lethal dose.
363
Largely eliminated the tipping problem?
Cassette vaporizer and TEC 6
364
Low pressure is ___psi
16 psi
365
Yoke check valve is part of _____pressure system
HIGH
366
Vaporizer check valves part of ____pressure system
Low.
367
When does scavenging occur?
After exhalation
368
2 actions in case of a suspected pipeline crossover
turn on back up O2 | Disconnect pipeline
369
Oxygen FLUSH valve is
BALL/SPRING valve
370
PRIMARY function of ANY free floating valve is to
Prevent gases from leaking out of the system.
371
Ball and spring valve function
ALL OR NONE | Permits gas flow after you have made a connection.
372
Open system reservoir, rebreathing
No reservoir, no rebreathing
373
Examples of open system
Nasal cannula | simple face mask
374
Open drop ether an ______system
Open
375
Insufflation is an example of what type of breathing system?
Open
376
The only system without reservoir is
OPEN
377
This breathing system requires INCREASES GAS FLOW
SEMI OPEN
378
Semi Closed and rebreathing , reservoir
Partial rebreathing | Reservoir
379
Mapleson worst for controlled ventilation
Mapleson A
380
Mapleson BEST for spontaneous ventilation
Mapleson A
381
Mapleson E
NO bag and valve
382
Maplesons mnemonic
``` A- APL by the patient B- Both APL and FGF by the Patient C- No corrugation D- APL Distant from the patient E- no bagee no valvee F- F***No valve ```
383
The most common CIRCUIT SYSTEM used today
BAIN circuit, which is a modified Mapleson D.
384
In the BAIN circuit, FGF is through a
SMOOTH tube not the corrugated tubing
385
Mapleson used in both spontaneous and controlled ventilation
BAIN
386
BAIN: FGF must be
2.5 X patient's MV
387
During controlled ventilation: best to least maplson
DFE>BC>A
388
Best mapleson preventing rebreathing during spontaneous ventilation
A>DFE>CB
389
LMA and coughing
less coughing on ermergence | Less risk of bronchospasm
390
LMA and airway reflexes
contraindicated with intact airway reflexes due to the risk of laryngospasm
391
LMA classic can it be used to facilitate fiberoptic or blind oral intubation
YES : LARGEST tube allowed is 6.0
392
LMA to establish an _____airway
EMERGENCY
393
The RODS mnemonic is used to
Identify difficulty extraglottic device situation
394
RODS stands for
Restricted mouth opening Obstruction Distorted airway or disrupted airway Stiff lung or stiff cervical spine
395
Peak airway pressure and LMA?
PAP < 20 cmH20 indicated
396
Initial cuff pressures will vary with the patient
LMA size, head position, anesthetic depth
397
LMA cuff pressure shouldd not exceed
60cm H20
398
What is the MOST COMMON ADVERSE EFFECT of Using LMA
SORE THROAT
399
FASTRACH LMA features
CURVED RIGID AIRWAY tube Integrated GUIDING HANDLE EPIGLOTTIS ELEVATING BAR GUIDING RAMP
400
What part of the FASTTRACH LMA is used for insertion , reposition and removal?
The Intergrated handle at the proximal end of the barrel.
401
The position of the FASTrach LMA can be optimized by
LaAN P(Lateral - anterior Posterior manipulation by using the INTERGRATED handle.
402
What is the CHANDY maneuver?
lateral , anterior posterior manipulation of the handle.
403
What is the LMA Proseal
The first DOUBLE lumen SGA
404
The 2nd lumen of the LMA proseal is used for
Diagnosis of malposition passive emptying of stomach Active emptying of stomach
405
The LMA proseal vs LMA supreme
LMA supreme is a single use version of the proseal
406
When selecting an LMA proseal , you should
SIZE DOWN from the LMA classic size
407
KING Laryngeal tube: cuffs
SMALL ESOPHAGEAL CUFF | Larger HYPOPHARYNGEAL CUFF
408
After insertion of King Laryngeal cuff
BOTh CUFF INFLATED by injecting air into JUST ONE inFLATION PORT
409
King Laryngeal tube if ventilation is inadequate
tube too deep
410
Cannot intubate cannot ventilate tube
Esophageal tracheal combitube ( ETC)
411
Adverse effects of SGAs
Aspiration | Sore throate
412
Single use SGAs/
Most SGAs are not disposable, single use.
413
SGA specific cleaner
Endozime
414
Max use per LMA
40
415
When fully inserted the LMA rest agains the
UPPER esophageal sphincter
416
Largest ETT tube through size 3-6 LMA
3- 6.0 mm 4- 6.00 5 -7mm 6- 7mm
417
LMA size and largest ETT size 1-2.5> how to remember?
``` Add "2.5 to each size" Size 1 + 2.5 = 3.5 Size 1.5 + 2.5 = 4 Size 2 + 2.5 = 4.5 Size 2.5 + 2.5 = 5 ```
418
Neonates to children up to 30 kg (<5, 5-10, 10-20, 20-30) Max cuff volume
4, 7, 10, 14
419
LMA size 3 - 6 max cuff volume
3, 4, 5, 6 | 20,30,40,50
420
Fiberoptic size (mm) for LMA neonate <5kg up to 30kg
2.7, 3, 3.5, 4.0
421
Which nerve when stimulated will cause laryngospasm?
Stimulation of vagus nerve during light anesthesia (S
422
LMA vs ETT bronchospasm and laryngospasm is
LESS with ETT
423
BIS with low probability of explicit recall
70-60
424
GA BIS
40-60
425
DEEP hypnotic state BIS
40-20
426
FLAT LINE EEG BIS
0-10
427
Light anesthesia BIS
90-70
428
Large V wave
TR RV failure Constrictive pericarditis Tamponade.
429
RA pressure range
1-8mmhg
430
Hypovolemia CVP_____PCWP____
Low low
431
LV failure CVP ________ PCWP ____
Normal or high | High
432
Cardiac Tamponate: CVP ______PCWP___
High; high
433
PE: CVP_______PCWP
High; nomral
434
Max wedge time
15 seconds
435
Insertion site PAC
1. Su (Subclavian) 2. RIJ (Right IJ) 3. LIJ (Left IJ) 4. RA (Right Antecubital) 5. LA(Left Antecubital) 6. Femoral ``` To RIGHT ATRIUM 15 (+10 for RV, + 15 for PA) 20 (+10 for RV, + 15 for PA) 25 (+10 for RV, + 15 for PA) 40 (+10 for RV, + 15 for PA) 45 (+10 for RV, + 15 for PA) 50 (+10 for RV, + 15 for PA) ```
436
Aline upstrokes reflects 2
Contractility and SVR
437
Upstroke is faster is contractility is_____and SVR is_____
Increased; decreasd
438
Function of valve is to change pressure
Diaphragm
439
This valve regulates the flow of N2O vial oxygen pressure
Fail safe valve
440
Free floating valve
Cylinder valve
441
Pulse ox is used to assess
Oxygenation
442
May cause falsely elevated pulse ox reading
Methemoglobin
443
Assessing a patient's CO2 elimination by END tideal CO2 measurement is called
CAPNOMETRY
444
DISS PREVENTS accidental misconnections by altering
Size of connection, type of pipe thread
445
CYLINDER REGULATOR first stage convert cylinder pressure to
45 pSI
446
The most fragile part of the gas machine is the
FLOW TUBES
447
Cauda equina extends
L1 to S5
448
Epidural space widest at
L2
449
Narrowest at level
C5
450
The epidural space is a
POTENTIAL SPACE that is bound by the DURA and LIGAMENTUM FLAVUM
451
The principle site of action of neuraxial blockade is the
NERVE ROOT within the spinal cord.
452
The best means for treating HYPOTENSION during spinal anesthesia is
PHYSIOLOGIC not pharmacologic. GIVE IV FLUIDS if not normovolemic, if NORMOVOLEMIC give ephedrine.
453
Fibrinolytic or thrombolytic no neuraxial for
10 days
454
Heparinization can occur
1 hour after catheter removal
455
Clavicles level
C4
456
Skin to epidural space average adult
4-6cm
457
Order of sensitivity to LA block is
large myelinated > smaller myelinated > unmyelinated
458
To assess lost of temperature sensation: most sensitive indicator
ALCOHOL swab to assess loss of temperature sensation is the most sensitive indicator of initial onset of sensory block. PINPRICK MOST ACCURATE OVERALL>
459
Anechoic
Appears black on image
460
Hyperechoic
Appears bright
461
HOW MUCH TO INJECT FOR AXILLARY BLOCK
40 ML
462
CERVICAL PLEXUS BLOCK
4 ML
463
HOW MUCH TO INJECT FOR ISB ?
40 ML
464
SUPRACLAVICULAR + INFRACLAVICULAR
20-30 ML
465
Medial RADIAl nerve how much
4 ML
466
Ankle BLOCK
``` Posterior tibial DEEP PERONEAL SURAL Saphenous Superficial PERONEAL ```
467
Common nerve aka
fibular nerve
468
Responsible for pain and temperature
C and unmyelinated
469
The most common causative organism in epidural abscesses is
Staphylococcus aureus
470
The posterior dermatomes located at L4 correst to
Intercristal line Tuffers line Superior iliac crest
471
Hypobaric
sterile water
472
Isobaric
CSF
473
Hyperbaric
Dextrose
474
To avoid catheter migration during or following the combined spinal epidural anesthetic, which spinal needle gauge size would be appropriate
28Ga
475
3 in one block is (LOM)
Lateral femoral cutaneous Obturator Femoral
476
1sst and 2nd most common nerve injury post op
Ulnar nerve | Brachial plexus.
477
Claw hand associated with
Ulnar nerve injury
478
Foot drop associated with
Lithotomy
479
Results in permanent vision loss
Ischemic optic neuropathy
480
Left arm abducted > 90 degrees
Brachial plexus
481
Opposition of the first and fifth finger is preclcuded
median nerve injury
482
Weakened skeletal muscle below the knee is a symptom of what injury
SCIATIC
483
Most common injured nerve of the lower extremity
common peroneal
484
Plantar flexion for a long time which nerve at risk
anterior tibial
485
Compression of this nerve against the pelvic brim
Femoral
486
Saphenous nerve is a branch of the
FEMORAL
487
Unable to adduct leg, decrease sensation medial thigh
OBTURATOR ( saphenous is only sensory)
488
IM injection vein in UPPER outer quadrant of the buttock to prevent injury to the
SCIATIC
489
3 nerves causing foot drop
Sciatic Common peroneal Anterior tibial.
490
Pregnancy and FRC
Decreased by 20%
491
Lungs that remains unchanged
TLC, VC, IC
492
Ventilation and pregnancy
MV increases 45% | Alveolar ventilation increase 45%
493
Oxygen consumption
Increase 20% to 30% at rest | 100% in 2nd stage of labor
494
HR and pregnancy
Increase 20-30%
495
CO increases mainly due to
increase in SV
496
Coagulation and fibrinogen in pregnancy
increased
497
Considered full stomach starting week
12
498
Dilutional anemia is due to
Increased in Plasma volume to a greater extend than Red blood cell volume.
499
CO , SV, HR
CO up 40-50% SV up 20-50% HR up 20-
500
Decreased factor in pregnancy
11 and 13
501
Unchanged factor
2 and 5
502
UBF at term is
700-800ml/min
503
2 factors causing decrease UBFl
decrease perfusion pressure
504
Pregnancy GFR, CO and RBF
ALL increased
505
BUN and CR in pregnancy
Normal due to increase in RBF and GFR
506
GFR increase by____% by ____th gestational week and remains elevated until delivery
50% ;16th,
507
Uterine artery pressure is determined by
Maternal systemic arterial pressure.
508
Definitive treatment for preeclampsia is
DELIVERY of the fetus
509
Diagnosis of preeclampsia can be made if
Thrombocytopenia <100000, Cr, 1.1
510
BEST Indicator of coagulopathy in the pre-eclamptic patient
PLATELET COUNT ON ADMISSION
511
Earliest sign of magnesium toxicity ?
Marked depresion of DTRs.
512
Level needed to be secured for a c-section
T-4
513
How much of the total uterine blood flow goes to the intervillous space?
550ml/min
514
Plasma fibrinogen DIC
<150 (in pregnancy 400-650)
515
Most serious in GASTROCHISIS
Dehydration and infection
516
high fever croup vs epiglotittis
Epiglottitis
517
Rapid vs slow progress croup vs epiglotittis
Rapid epiglottitis
518
Within umbilical vs lateral to umbilitus
Omphalocele(within) | Gastrochisis (Lateral )
519
Omphalocele mortality related to
CaRdiac and chromosomal abnormalities.
520
No amnion with
Gastrochisis
521
Cystic fibrosis: resp pattern
Obstruction pattern
522
Early symptoms NOT SIGN of MH
Masseter spasm | Tachycardia
523
Early SIGN of MH
Increased ETCO2 peaked t waves on ECG HYPERKALEMIA
524
Hallmark of intravascular fluid depletion in neonate and infants is
Hypotension without tachycardia
525
Major cause of perioperative morbidity and mortality in pediatric patients
Hypoxia
526
Congenital diaphragmatic hernia profound arterial hypoxemia is due to
RIGHT TO LEFT SHUNT
527
Pediatric major mechanism for heat production
Nonshivering thermogenesis
528
Concern for paradoxical air embolism may occur in the neonate because of
Patent foramen ovale
529
Correct ETT tube is confirmed by
Bilateral breath sounds
530
In a patient with congenital diaphragmatic hernia, peak inspiratory airway pressure be
20
531
A child is born with congenital diaphragmatic hernia, which pathways allow blood to bypass the lung completely
Patent Foramen of fallot | Patent ductus arteriosus
532
PRevent hypothermia with gastrochisis vs omphalocele
Gastrochisis
533
Correct dose of dandrolene
2-3 mg/kg every 5-10 minutes
534
Obese surgical patients leads that are best to detect cardiac ischemia
Lead V5, Lead I
535
Do not exceed this PEEP for obese patient
15cmH2o
536
What is the most common cause of postoperative mortality after bariatric surgery?
THROMBOEMBOLISM
537
Appropriate pre-op anesthetic plan for cardiac tamponade
Positive inotrope
538
Accidental SUBARACHNOID injection occurs during intended epidural, RAPID early sign is
DYSPNEA
539
Max dose of dandrolene treat MH
10 mg/kg
540
In PACU patient stated that she remembers some stuff you should
Tell the patient what happened
541
Stimulation of what receptor explains why arterial diastolic BP may decrease when epinephrine is administered with a local anesthetic?
Beta 2 adrenergic receptor
542
At NMJ, aminophylline
INCREASES THE RELEASE OF ACH from the motor nerve terminal
543
Votalge gated sodium channel is in the INACTIVATED state in all but which of the following situation>
Severe hypokalemia
544
Patient cannot ADDUCT the thumb what nerve is blocked by LAs
ULNAR
545
Aspiration is a risk associated with anesthesia for patients with each of the following diseases except
MS
546
Immediate deliver if decelerations are
LATE with no beat to beat variability
547
Applying pressure for the patient who has already lost consciousness how much pressure in KG?
4 kg
548
ANSI standards for reservoir bag require that the pressure not exceed _____when the bag is distended how many times its normal capacity ?
50cm H2O ; 4
549
The American national standards institute Z79.9 1979 was replaced in ________ with
1988; American Society for TESTING and materials F1161-88 standard.
550
2 year old ETT tube + suction catheter
4.0 at 8F
551
Muscle that DILATES the vocal cords
Posterior cricoarytenoids (thought thryroarytenoids)
552
Hypoxemia during one-lung anesthesia is most effectively treated by:
periodic inflation of the collapsed lung with oxygen, early ligation of the ipsilateral pulmonary artery and CPAP to the collapsed lung offer consistently effective improvement in oxygenation. The application of PEEP to the ventilated lung, changes in the ventilatory parameters and oxygen insufflation to the collapsed lung may offer marginal improvement in oxygenation.
553
FEV 1 of 2L and FVC of 2.5 L suggest
RESTRICTIVE (ratio is 0.8 but volumes are low )
554
What happens to blood flow and the diameter of arterial blood vessels in ischemia region of the brain when the patient is hyperventilated?
Blood flow increase | Arterial vessel diameter NO CHANGE
555
Produce the GREATER blockade when in the epidural space?
3% Chlorprocaine
556
In chronic respiratory acidosis, the PaCO2 is
elevated above the upper limit of the reference range, with a normal or near-normal pH secondary to renal compensation and an elevated serum bicarbonate levels (ie, >30 mEq/L).
557
Incidence of PERIOPERATIVE reinfarction for a patient who had an MI 7 months ago is
5%
558
Protamine dose and bond
1.1 -1.3 mg per 100 units of heaprin. IONIC BOND
559
3 in 1 block FOL
Femoral Obturator Lateral femoral cutaneous nerve.
560
Hernial sac Gastrochisis
ABSENT
561
Is a Hernial sac present with omphalocele?
Yes it's Present
562
Congenital abnormalities gastrochisis
PRESENT
563
Omphalocele congenital abnormalities
Absent
564
TEC 6 VAPORIZER calibrated in LA is brought to colorado springs, the % delivered willbe
HIGHER than the dial setting.
565
Concentration and dose of mannitol is
20%, 1g/kg
566
Who is responsible for quality assurance?
The hospital
567
What drug would you not give in the perioperative period to the patient undergoing surgery for pheochromocytoma
DROPERINOL.However, droperidol when used in pheochromocytoma, has been reported to produce a paradoxical hypertensive response.
568
Most SENSITIVE for VAE?
TEE
569
What drug for altering hemodynamic status should generally be avoided in the patient with idiopathy subaortic hypertrophic stenosis?
NITROGLYCERIN (REDUCE CO)
570
Drugs to be avoided in the patient with cystic fibrosis?
ATROPINE
571
INCREASE with aging
PaCO2
572
Vital capacity with aging
Decreases
573
Bladder cancer removal procedure
Controlled Cystectomy
574
Bladder cancer removal procedure
Radical Cystectomy
575
Needed for RADICAL CYSTECTOMY
Controlled hypotension
576
Pulmonary parameters that decrease in geriatric
Total lung capacity.
577
breast milk fasting
4 hours
578
3 months to 3 years EBV
75-80ml
579
At what point during pregnancy does the maternal intragastric pressure increase, often resulting in heartburn?
3rd trimester
580
Breathing circuit pressure is limited to
125cm H2O
581
Which of the following are part of the intrinsic laryngeal muscles
Cricothyroid Oblique artytenoid Thyroarytenoid
582
Prominent pathophysiologic derangements associated with MR?
LV volume overload
583
End result of INCREASED in HR in patient with Mitral stenosis?
PULMONARY EDEMA
584
Signs and symptoms of RA include
Pain on swallowing
585
HYPERVENTILATION produces which electrolyte disturbance
HYPOCALCEMIA
586
Not a Quaternary ammonium
Physostigmine
587
How many unidirectional valves does the semiclosed anesthetic breathing system have?
2
588
Compare the difference between MEANS of three of more NORMALLY DISTRIBUTED DATA SETS would be
ANALYSIS of VARIANCE
589
Not a contraindication to Jet ventilation
Patient under 2 years of age.
590
IMPORTANT CV effect of pneumoperitoneum
Distention of the vagus nerve during insufflation
591
2, 3 DPG is which biochemical pathway
GLYCOLYSIS
592
Nominal data
yes or no Eye color Blood type Male or female without providing any quantitative value.
593
Interval data
statistical research, school grading, scientific studies and probability
594
Ordinal data?
well-known example of ordinal data is the Likert scale.
595
Ordinal data example
Age, gender
596
Test is most appropriate to evaluate the difference between expected and observed frequencies from nominal data?
Chi-squared analysis
597
Electrolyte disturbances are expected during WHIPPLE ? low CKM
HYPOCALCEMIA HYPOKALEMIA HYPOMAGNESEMIA
598
Nerve supplies motor innervation to the superior oblique muscle of the eye?
TROCHLEAR
599
St john's wort is an inducer, what else should you know about it?
CNS Stimulation
600
Echinacea is associated with
Immunosuppression | Hepatic dysfunction
601
Black Cohosh is associated with
Hypotension
602
Garlic, Ginseng, Ginger , Gingko all associated with
increased bleeding
603
Ginseng is associated with increased bleeding, what else should you know about it?
CNS stimulation
604
Hoodia herbal supplements is associated with
Altered glucose control
605
Kava herbal supplements anesthetic considerations:
CNS depression, decreased MAC
606
Valerian herbal supplements anesthetic considerations:
CNS depression, decreased MAC
607
Herbal meds and supplements are stopped
2 weeks before surgery.
608
Herbal meds and supplements: REGULATED by FDA
No!!!
609
Catechol-O-methyltransferase (COMT) metabolizes epinephrine to and
metanephrine
610
Catechol-O-methyltransferase (COMT) metabolizes | norepinephrine to
normetanephrine.
611
Subsequently, monamine oxidase (MAO) further metabolizes metanephrine and normetanephrine to
vanillymandelic acid (VMA).
612
What enzyme further metabolizes metanephrine and normetanephrine to
vanillymandelic acid (VMA).
613
The sensory neuropathies associated with HIV include.
distal sensory polyneuropathy and antiretroviral toxic neuropathy (ATN) secondary to the treatment
614
Occurs in 10% to 35% of patients who are seropositive for human immunodeficiency virus (HIV).
Symptomatic neuropathy o
615
Occurs in 10% to 35% of patients who are seropositive for human immunodeficiency virus (HIV).
Symptomatic neuropathy
616
Characteristics of human immunodeficiency virus neuropathy include:
Distal polyneuropathy | Allodynia
617
The clinical features of HIV sensory neuropathy typically include.
painful allodynia and hyperalgesia. The onset is gradual and most commonly involves the lower extremities
618
The neuropathy and dysesthesia associated with HIV progress from the
distal to the more proximal structures.
619
Postintubation croup: is secondary to
inflammation of subglottic structures
620
Postintubation croup usually occurs at the
level of the cricoid, since this is the narrowest part of the pediatric airway.
621
Postintubation croup is associated with
early childhood (1 - 4 years).
622
Unlike laryngospasm, postintubation croup is seen
some time after extubation, usually within 3 hours.
623
Evoked motor response of the tibial nerve using a nerve stim would most expected to elicit
Plantar flexion at the ankle and foot inversion
624
Intraosseous access for babies
Tibial 1-2 cm below but also medial to the tibial tuberosity
625
Highest sensitivity vs highest specificity for pheochromocytoma tests
Highest specificity is Urinary VMA | Highest sensitivity is Plasma free metanephrines.
626
The web space between first and 2nd toes are innervated by
Deep peroneal nerve
627
Child with Epiglotittis induction of anesthesia should occur where?
In the operating room with the presence of a skilled surgeon as well as advanced airway management equipment
628
Child with Epiglotittis induction of anesthesia preferred method and whY?
Inhalation induction, allows for spontaneous ventilation . MAINTAINING INTACT AIRWAY TAKES PRIORITY since patient at high risk for airway compromise.
629
Most common complication occuring in the PACU
NAUSEA
630
Most common complication following a retrobulbar block prior to cataract surgery
HEMATOMA because of close proximity of the ophtalmic artery
631
Most important aspect of a successful TAP BLOCK
Using adequate volume of LA. Spread throughout a fascial plane
632
Blood loss spinal vs GA for THA
Less blood loss with spinal
633
Spinal stenosis patients report pain that
Exacerbates by standing or walking
634
Hallmark of spinal stenosis
relief of symptoms with bending forward.
635
The apneic oxygenation technique affords adequate oxygen delivery, but progressive respiratory acidosis limits the use of this technique to 10 - 20 minutes in most patients. Arterial PaCO2 rises
rises 6 mm Hg in the first minute followed by a rise of 3 - 4 mm Hg during each subsequent minute. In this patient this will produce a 27 - 34 mm Hg increase, resulting in a PaCO2 of 67 to 74 mm Hg.
636
Insulin secretion is increased by
stimulation of the parasympathetic nervous system through the vagus nerves.
637
Key elements in the AANA's definition of wellness include: (Select 3)
effective adaptation, resilience, coping mechanisms
638
IntraOcular pressure with succinylcholine
Increase
639
IntraOcular pressure with hypoxemia
increase
640
IntraOcular pressure with laryngoscopy
increase
641
The most powerful inspiratory muscles are the
external intercostals.
642
Raise the sternum and contribute to inspiration_______ as do the _______and ______
The sternocleidomastoid muscles ; anterior serratus and scalene muscles.
643
The primary muscles of expiration are the
abdominus rectus muscles and the internal intercostals.
644
A patient is undergoing a pulmonary function test in which they are asked to inhale and exhale as deeply as possible for 15 seconds. What is the test called?
Maximum voluntary ventilation
645
Because the partial pressure of oxygen in the alveoli is higher than it is in the blood, it will move across the pulmonary capillary membrane into the blood by
diffusion.
646
The carotid bodies are capable of sending messages to the central respiratory centers to increase ventilation via the
glossopharyngeal nerve
647
Under what structure does the right recurrent laryngeal nerve pass?
Innominate artery
648
These are the only causes of true hyperventilation (where the patient's minute ventilation increases to the point that respiratory alkalosis results). They are:
arterial hypoxemia metabolic acidosis, and central nervous system alteration.
649
Respiratory Alkalosis electrolyte disturbances: | K+; Ca2+, BP, Phosphate , _____and ______
hypokalemia, hypocalcemia, hypotension, hypophosphatemia, cardiac dysrhythmias, and potentiation of digoxin toxicity. 
650
Serotonin is a vasoconstrictor in most vascular beds, but has vasodilatory properties in the
vasculature of the heart and skeletal muscle.
651
Local anesthetics produce an ordered progression of blockade of
``` Temperature sensation first Proprioception (kinesthetic sense) Motor function Sharp pain Light touch. ```
652
The primary mechanism by which gastroesophageal reflux occurs is a
transient lowering of the lower esophageal sphincter pressure, not a chronic decrease in the lower esophageal sphincter pressure.
653
NSAIDs fundamentally inhibit the synthesis of
Prostaglandins
654
Which of the following calcium channel blockers would be most effective at relieving chest pain due to myocardial ischemia? (select two)
nifedipine | nicardipine
655
The profound hypotension seen with spinal shock is related to the level at which the lesion is located (cervical injuries produce more severe hypotension than do lumbar injuries) and is due primarily to a
drop in preload caused by dilation of the capacitance vessels.
656
Pt had a stroke about 3 months ago ,should you proceed with surgery?
Patients who have a perioperative stroke are eight times more likely to die within 30 days of surgery. Because of this, elective surgery should be delayed for at least 9 months following a stroke
657
Injecting 2 mL of local anesthetic at the base of the palatoglossal arch will anesthetize which branches of the glossopharyngeal nerve? (select two)
Pharyngeal and lingual
658
Upon what factors does the composition of the inspired gas mixture a patient receives depend? (select four)
The vaporizer dial setting The fresh gas flow rate The volume of the breathing circuit Gas absorption by the circuit
659
The response of the orbicularis oculi most closely represents that of the
adductor pollicis
660
Monitoring the corrugator supercilii muscles will most closely parallel that of what muscles?
the laryngeal adductor muscles.
661
At an increased altitude, an older Tec isoflurane vaporizer will deliver
a higher volume percent than the dial setting. For example, at 10,000 feet the atmospheric pressure is about a third less at 500 mmHg. If we turn on our isoflurane vaporizer at 0.89%, the decrease in ambient pressure results in a doubling in the volume percent output of the gas from 0.89% to 1.75%. But, if we multiply that 1.75% times 500 mmHg (the new atmospheric pressure) we get a partial pressure of isoflurane of 8.77 mmHg. So despite a huge jump in the percent output, the partial pressure doesn't increase that much.
662
A decrease in the in the single twitch response isn't seen until what % of the receptors are blocked? When does the response disappear?
75-80% of the receptors are blocked, and the response disappears when 90% of the receptors are blocked
663
Which alteration would be consistent with the development of a leak in the bellows in a system using an oxygen-driven ventilator? (select two)
An increase in the FiO2 | An increase in peak inspiratory pressure
664
At standard pressure, the boiling points for inhalation anesthetics in degrees Celsius are: Desflurane-Isoflurane-48.5, Halothane-50.2, Enflurane-56.5, and Sevoflurane-58.5.
22.8,
665
At standard pressure, the boiling points for inhalation anesthetics in degrees Celsius are : ISO
48.5
666
At standard pressure, the boiling points for inhalation anesthetics in degrees Celsius are : Halothane-
50.2,
667
At standard pressure, the boiling points for inhalation anesthetics in degrees Celsius are :Enflurane
56.5,
668
At standard pressure, the boiling points for inhalation anesthetics in degrees Celsius are Sevoflurane
-58.5.
669
At standard pressure, the boiling points for inhalation anesthetics in degrees Celsius are : HIGH to low mnemonic
DI -HES
670
Rh(D) immune globulin is administered to prevent Rh sensitization in
Rh-negative women.
671
Induction of general anesthesia for which of the following procedures carries the highest risk for aspiration?
Zencker's Diverticulostomy
672
Zencker's Diverticulostomy induction
Always RSI
673
Contraindication to the administration of intravenous contrast media : women
Pregnancy is
674
The onset of neuromuscular blocking agents is prolonged in the elderly primarily because of (select two)
an increase in circulatory time | a decrease in skeletal muscle blood flow
675
What are the three most common entry sites for an amniotic fluid embolism?
Placenta Endocervical veins Uterine trauma site
676
What hemodynamic change would you expect to see when the anhepatic phase of a liver transplant is initiated?
Hypotension
677
What is the drug of choice for the treatment of acute myocardial ischemia?
Nitroglycerin
678
The formula for PBW for males is:
PBW (male kg) = 50 + 0.91 X (height (cm) - 152.4).
679
The formula for PBW for females is:
PBW (female kg) = 45.5 + 0.91 X (height (cm) - 152.4).
680
The PR interval should be measured from the ___ of the P wave to the ___ of the QRS.
beginning, beginning
681
What are the only intravenous anesthetics that can produce burst suppression?
Etomidate and propofol
682
When inserting an Eschmann stylet during intubation, the stylet should be advanced into the trachea until
the 25 cm marking is at the lip