Random gen med Flashcards
magnesium role in muscle
stimulates calcium to be re taken up into sarcoplasmic reticulum
effect dopamine
effect serotonin
effect NA
euphoria
confidence
energy
Features of Gordons
Oposite of thiazides
Hyperkalaemia
metabolic acidosis
LOW renin and NORMAL aldosterone (weird as high K)
Hypertension
Treat with thiazides
Chronic alcohol ingestion does what to what receptor
enhances effect of GABA on neuroreceptors, reduces excitability
Withdraw–>hyperexcitability
When are three times that bone scan technetium 99 not helpful
myeloma- medullary
osteolytic mets eg renal cell
osteoporosis without fracture
Hypothermia ECG
J wave
Riluzole acts how
inhibits glutamate release
for muscle spasms in MND
for fasciulations in MND
spasms- baclofen
fasciculations- carbamaz and gabapentinq
Why is CKD not a cause of hypomagnesaemia?
because kidney mostly excretes
Causes of low Mg are
cistplatin, aminoglycoside, Tac/CycA
hyperaldosteronism
alcohol- causes renal tubule dusfunction and massive urinary EXCRETION
Hungry bone syndrome
how does pregabalin work
binds alpha 2 delta subunit of calcium channel in brain and superficial dorsal horn of spinal cord
Modulates release of neurotransmitters which are needed for pain
duration of anticoagulation post preg DVT
min 3 months and at least 6 weeks post partum
HAGMA and high osmolol gap
methanol poisoning or ethylene glycol
methanol–>metabolised to formaldehyde and formic acid–>retinal toxicity and optic nerve damage
ethylene glycol–>oxalic acid–>calcium oxalate and AKI with precipitation in tubules
for both- give fomepizole
In wernickes, thiamine fixes what quickly
ophthalmoplegia
Kidneys are allocated according to
survival of graft first priority (dont give to very sick person who is unlikely to live long)
Why is beta blocker not a first line antihypertensive?
increase risk diabetes
increase risk stroke
