Random facts Flashcards
Type 1 hypersensitivity
IgE antibody mediated binding to mast cells
leads to inflammatory response
e.g. asthma
Type 2 hypersensitivity
IgG or IgM binds to antigen on cell surface
can be autoimmune or extracellular antigens presented on host cells
Type 3 hypersensitivity
immune complex mediated
free antigens and antibodies form immune complexes and are deposited into certain tissues
Type 4 hypersensitivity
T-cell mediated
delayed
Chronic bronchitis
Chronic productive cough for at least 3 months in the last 2 years
Sarcoidosis associations?
uveitis
erythema nodosum
lymphadenopathy
hypercalcemia- due to activation of vitamin D
elevated ACE- cells surrounding granulomas can produce increased ACE
DLCO (diffusing capacity)
measure of CO uptake by lungs from a single inspiration over a certain time
exhaled and inhaled air samples tested for content of CO tracer
may show diffusion impairments e.g. PF
Adjustments for DLCO?
Anaemia and altitude
Where is the CFTR gene located? what does it stand for?
long arm of chromosome 7
Cystic fibrosis transmembrane conductance regulator
When is surgery for lung cancer not an option?
vocal cord paralysis
when tumour is too near the lung hilum
FEV1 < 1.5L
metastases
treatment for IPF?
supportive and symptom management
IPF is more common in ___ and ______.
it commonly presents between age __ and __.
men
smokers
50
60
Mesothelioma may have a ___ period of __ years between exposure and diagnosis.
lag
45
cure for mesothelioma is?
none
5 year survival is <5%
Squamous cell carcinoma is not related to smoking. T OR F?
F
