Random Facts Flashcards
hep C has increased propensity for developing what….
antithyroid antibodies –> hypothyroidism
TCF7L2
transcription factor mutated in type II DM part of WNT signaling pathway that has a role in B cell development
abnormal nuclear transcription factor in B cells resulting in decreased Apo M and decreased clearance of HDL (which is not cardioprotective)
strong family history
no ketoacidosis when off insulin for 3 weeks
negative autoantibodies
detectable Cpeptide levels
not obese
MODY
how do you treat MODY 3 which is the most common
responds to Sulfonylureas
what drugs cause hyperglycemia
beta blockers glucocorticoids antipsychotic- olanzapine oral contraceptives pentamidine niacin cyclosporin (immunosuppressant)
what do diacylglyceride and ceramide
TNF alpha and resistan do
block insulin receptor activity and signaling pathways
obesity induced insulin resistance
thus the insulin effect to block gluconeogenesis and glucogenolysis is gone
post prandial hypoglycemia
nesidioblastoma
pancreatic cell hyperplasia
