Random diseases

Question 1

Pyknodysostosis

Answer 1

AR cause of osteopetrosis and short stature
Hypoplastic terminal phalanges
Delayed closure of sutures
Multiple long bone fractures
Frontal and occipital bossing

Question 2

Felty syndrome

Answer 2

RA, splenomegaly, neutropaenia

Occurs in 1% of patients with RA

Question 3

Osteopetrosis

Answer 3

Infantile AR and adult AD forms
Defective osteoclasts
Sandwich vertebrae

Question 4

Sandwich vertebrae

Answer 4

Osteopetrosis

Question 5

Hair-on-end

Answer 5

Thickened diploic trabeculae from intramedullary haematopoiesis
HI NEST
Hereditary spherocytosis, iron deficiency, neuroblastoma, enzyme defn (G6PD - haemolytic anaemia), sickle cell, thalassaemia

Question 6

Looser zones

Answer 6

Type of insufficiency fracture
Transverse lucency, not going right across bone
Most common with osteomalacia and rickets

Question 7

Caffey disease

Answer 7

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