Random Days Flashcards
Cytotoxins produced by CD8 cells
perforin, granzymes, granulolysin
cytokines produced by CD8 cells
IFN (interferon)-gamma, LT, TGF-beta, IL10
Cytokines produced by TH1 CD4 cells
IL-2, IFN-gamma, GM-CSF, TNF-alpha, LT, IL-3
Cytokines produced by TH4 CD4 cells
IL-4, IL-5, IL-10, IL-13, TGF-beta
Cytokines needed to differentiate CD4 cells to TH1
IL-12 , IFN-gamma
Cytokines needed to differentiate CD4 cells into TH2
IL-4, IL-6
How does Ag presentation to TH0 cells induce differentiation?
Low affinity or low conc of Ag= TH2
High affinity or high conc of Ag= TH1
What do IL-2 and IFN-gamma secreted by TH1 cells drive?
Macrophage and B-cell activation, production of opsonizing antibodies such as IgG1
What do IL4 and IL5 secreted by TH2 cells drive?
general activation of B-cells to make Abs
What inhibits the growth of TH1 cells?
IL-10 and TGF-beta
What inhibits the growth of TH2?
IFN-gamma
What inhibits the development of TH17?
IL-4 and IFN-gamma
What drives differentiation into TH17?
TGF-beta, IL-6, IL-21, IL-23
What do TH17 cells produce?
IL-17 (neutrophil recruitment and activation) and IL-22 (which stimulates epithelial cells to produce antimicrobial proteins)
What happens to L-selectin in reference to CD8 cells?
IT is downregulated because they have no role in secondary lymphoid tissues
