Random Days Flashcards
Cytotoxins produced by CD8 cells
perforin, granzymes, granulolysin
cytokines produced by CD8 cells
IFN (interferon)-gamma, LT, TGF-beta, IL10
Cytokines produced by TH1 CD4 cells
IL-2, IFN-gamma, GM-CSF, TNF-alpha, LT, IL-3
Cytokines produced by TH4 CD4 cells
IL-4, IL-5, IL-10, IL-13, TGF-beta
Cytokines needed to differentiate CD4 cells to TH1
IL-12 , IFN-gamma
Cytokines needed to differentiate CD4 cells into TH2
IL-4, IL-6
How does Ag presentation to TH0 cells induce differentiation?
Low affinity or low conc of Ag= TH2
High affinity or high conc of Ag= TH1
What do IL-2 and IFN-gamma secreted by TH1 cells drive?
Macrophage and B-cell activation, production of opsonizing antibodies such as IgG1
What do IL4 and IL5 secreted by TH2 cells drive?
general activation of B-cells to make Abs
What inhibits the growth of TH1 cells?
IL-10 and TGF-beta
What inhibits the growth of TH2?
IFN-gamma
What inhibits the development of TH17?
IL-4 and IFN-gamma
What drives differentiation into TH17?
TGF-beta, IL-6, IL-21, IL-23
What do TH17 cells produce?
IL-17 (neutrophil recruitment and activation) and IL-22 (which stimulates epithelial cells to produce antimicrobial proteins)
What happens to L-selectin in reference to CD8 cells?
IT is downregulated because they have no role in secondary lymphoid tissues
What happens to VLA-4 on effector T cells?
It is upregulated in order to allow binding to VCAM-1 on endothelial cells to facilitate movement into inflammatory sites
CD45RA
marker on naïve T cells
CD45RO
marker on activated and memory T cells
What is the ligand for CD8 cells?
Fas ligand
What is the ligand for CD4 cells?
CD40 ligand on CD4 cells binds to CD40 on APC
What is the primary function of CD4 cells?
to supply the critical secondary activation stimuli needed to activate an Ag-specific B-cell and drive their differentiation
