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Cytopathology > Random Cyto Stuff > Flashcards

Random Cyto Stuff Flashcards

1
Q

Liquid based prep # of cells for Pap?

Conventional?

Report endometrial cell in what age or above?

A

LBP: 5000

Conventional: 8000-12000

45yrs

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2
Q

Age to start pap testing?

IF normal what range can you do 3 year screening?

What ages cotest?

What age to stop?

A

21 yrs

21-30; every 3 years if normal

31-64 yrs; Pap every 3 or Pap and HPV every 5; only HPV test high risk types!

65 yrs+; stop if normal in last 10 yrs

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3
Q

Pleomorphic adenoma has what 3 things?

Leptothrix occurs with?

Koilocyte caused by what protein?

A

Epithelial, myepithelial, and fibrous material

Trichamonas (gives halos)

E4

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4
Q

Glycogenated nuclei in liver common from?

Urine with round glassy cell, think?

Oncocytic cells in liver?

A

Wilson’s is most common

Polyoma Virus

Fibrolamella tumor

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5
Q

Smudgy nucleus and cillia, what virus?

Thyroid with plasmacytoid/polygonal cells and “colloid”?

A

Adeno!

Medullary CA! Not colloid but amyloid

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6
Q

Exodus days in mestrual cycle?

A

6-10. Looks like a ball of stroma and cells in pap

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7
Q

Pap: Cookie cutter/spider cells?

Birth control pills show what on pap?

Post menopausal changes show?

A

Think metaplastic before HSIL!

Microglandular hyperplasia!!

Dirty background, inflammation and parabasalar cells and sometimes blue globs

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8
Q

Snow shoe like organism on pap?

What does AIS lack?

Pap with adeno like cells that are refractive with Eosinophils, consider?

A

Alternaria (lab contaminant); kind of looks like a herpes cell..?

Lacks prominent nucleoli: has feathering edge and abundance of cells with dark chromatin and microacinar structures

Glassy cell!

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9
Q

Crystaline material in pap name/significance?

Follicular cervicitis consider what organism?

Cornflaking cells on pap are caused by?

A

Cocklebur’s. No significance!

Chlamydia

Air; recover slip

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10
Q

Plate like crystal that look like square crystals?

Hashimoto’s thyroditis shows what cells?

A

Cholesterol

Hurthle and lymphocytes

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11
Q

Rearrangement genes in PTC?

IHC for PTC:

Medullary IHC and EM?

A

RET and TRK

TG+, TTF1+, CK+, EMA+, CEA-, Calcitonin -

Calcitronin +, CEA+, TTF1+, Neuro endo +; Neurosecretory granules/amyloid

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12
Q

Sialadenitis findings; what kind of crystals?

Warthin’s tumor shows on cyto?

Findings of Pleomorphic adenoma?

A

Salivary gland tissue with enlarged ducts; but not “globules” like adenoid cystic

Sialadenitis: Square crystals of amylasse

Warthin: Onococytic and lymphocytes; associated with smoking

Magenta fibrillary background and epithelial and myoepitheal cells; PLAG1 and HMGA2

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13
Q

Pleomorphic adenoma has what kind of crystals?

Adenoid cystic has what cyto finding; classic clinical finding?

Most common malignant salivary gland tumor and cyto findings?
What Gene?

A

Tyrosine!; Petal shape pink crystals

Gumballs and really dark nuclei!; Also facial nerve pain or paralysis

Muco-ep: 3 cell types-glandular, intermediate, squamous
MAML2

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14
Q

Adenoid cystic carcinoma mutations?

Does it have fibrillary background?

A

MYB-NIFB fusion and c-kit

No mucoid background

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15
Q

Acinic cell carcinoma cyto findings?

Does it have ducts?

A

Transversing capillaries, some bare nuclei, maybe granules and cohesive

No

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16
Q

Most common main salivary gland malignancy?

Gene test?

A

Muco-epidermoid

MAML2

17
Q
A
18
Q

FIbroadenoma vs. phyloides on FNA?

What can ductal carcinoma look like?

T/F Ductal Carcinoma has more vacuoles than lobular?

A

FA: Staghorn shape with normal stroma
PT: Stag horn as well but more cellular and atypical stroma

Plasmacytoid cells; no myoeplayer seen

F: Both might have them but lobular>ductal

19
Q

“Arrowhead, teardrop” in breast is buzzword for?

Medullary Ca associations?

A

Tubular carcinoma which is very bland looking; Best prognosis

BRACA, Triple Neg, and young black women

20
Q

Funny looking “fibroadenoma” in a man?

DDx of lung cell block with froathy eosinophlic material?

Curshman spiral associations?

A

Gynecomastia; lacks terminal ductal lobules!

Pcp, Pulmonary alveolar proteinosis

Asthmatics!

21
Q

Lung Charcot Laden crystal (small pink) think?

What is a Creola body?

Immunosuppressed patient with “negative rods” spaces, think?

A

Parasities; Crystal comes from Eosinophils

Catapiller like bronchial cells with cillia bodies in asthmatics

MAC.

22
Q

“Daisy cell” on lung FNA?

A

Benign mesothelial cells especially in women!

23
Q

In urine a coffin shaped lid is, see in what kind of urine?

6 sided crystals are?

Thread like crystals are made of?

A

Triple phosphate, 3-6 sides, seen in alkaline urine, disolved in acetic acid

Cystine (Sixtine)

Tyrosine

24
Q

Ileal conduit urine finding?

Lots of columnar cells in urine, think?

A

Round ileal cells, dirty background, Globular lysosomal inclusions called Meamed Wolinska bodies

Cystitis Glandularis

25
Q

Features of high grade urothelial carcinoma?

Features of low grade urothelial carcinoma?

A

High cellularity, Coy cells (single, high N:C, irregular memrbanes); Birds eyes/cell death, dirty back ground, dark nuclei and nucleoli

Loose or crowded cluster, enlarged uniform nuclei, no nuceloi, mild N:C increase, Clean background, Some irregular nuclear contours

26
Q

Urine polyoma virus findings?

DNA or RNA virus?

What Schisto causes bladder SCC?

A

Glassy smudgy inclusios (BK virus); aka Comet Cells

DNA

S. Haematobium, Periapical spike classic feature

27
Q

What is endocervicosis?

Is atypia a major feature?

A

Young women with bladder symptoms

Mass on posterior wall/dome

Irregular haphazard endocervical type glands without endocervical stroma

Minimal atypia

28
Q

Ugly yellow pigmented cells in males, worry or not?

Refractile hooklet’s seeon on liver FNA?

A

No, monster cells from seminal vesicle. Benign

Hydatid cyst; Echinococcus hook worm.

29
Q

Young male with eosinophilic tumor in liver not associated with cirrhosis?

Histologic features?

IHC?

A

Think fibrolamellar

Stelate scar, large polygonal eosinophilic cells

Low NC ratios; rare cytoplasic modies of fibrinogen

Lamellar fibrosis present in some cases

CK7+,CK8+,CD18+, Neuroendo+, AFP-

30
Q

What organism causes cholangiocarcinoma?

Cholangio staining IHC?

A

Clonorchis sinensis

MOC31+, PAS+, Mucin+, pVHL+CK7+, CK19+, pCEA (cytoplasmic)+ vs cannalicular in HCC, CK17-

31
Q

What fungus can give calcium oxalate crystals especially in BAL?

Dreaded complication?

Lateral squamous lined cyst is?

A

A. Niger!

Fatal pulmonary hemorrhage

Branchial cleft

32
Q
A

Cytopathology (1 decks)

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