Random Cyto Stuff

Question 1

Liquid based prep # of cells for Pap?

Conventional?

Report endometrial cell in what age or above?

Answer 1

LBP: 5000

Conventional: 8000-12000

45yrs

Question 2

Age to start pap testing?

IF normal what range can you do 3 year screening?

What ages cotest?

What age to stop?

Answer 2

21 yrs

21-30; every 3 years if normal

31-64 yrs; Pap every 3 or Pap and HPV every 5; only HPV test high risk types!

65 yrs+; stop if normal in last 10 yrs

Question 3

Pleomorphic adenoma has what 3 things?

Leptothrix occurs with?

Koilocyte caused by what protein?

Answer 3

Epithelial, myepithelial, and fibrous material

Trichamonas (gives halos)

E4

Question 4

Glycogenated nuclei in liver common from?

Urine with round glassy cell, think?

Oncocytic cells in liver?

Answer 4

Wilson’s is most common

Polyoma Virus

Fibrolamella tumor

Question 5

Smudgy nucleus and cillia, what virus?

Thyroid with plasmacytoid/polygonal cells and “colloid”?

Answer 5

Adeno!

Medullary CA! Not colloid but amyloid

Question 6

Exodus days in mestrual cycle?

Answer 6

6-10. Looks like a ball of stroma and cells in pap

Question 7

Pap: Cookie cutter/spider cells?

Birth control pills show what on pap?

Post menopausal changes show?

Answer 7

Think metaplastic before HSIL!

Microglandular hyperplasia!!

Dirty background, inflammation and parabasalar cells and sometimes blue globs

Question 8

Snow shoe like organism on pap?

What does AIS lack?

Pap with adeno like cells that are refractive with Eosinophils, consider?

Answer 8

Alternaria (lab contaminant); kind of looks like a herpes cell..?

Lacks prominent nucleoli: has feathering edge and abundance of cells with dark chromatin and microacinar structures

Glassy cell!

Question 9

Crystaline material in pap name/significance?

Follicular cervicitis consider what organism?

Cornflaking cells on pap are caused by?

Answer 9

Cocklebur’s. No significance!

Chlamydia

Air; recover slip

Question 10

Plate like crystal that look like square crystals?

Hashimoto’s thyroditis shows what cells?

Answer 10

Cholesterol

Hurthle and lymphocytes

Question 11

Rearrangement genes in PTC?

IHC for PTC:

Medullary IHC and EM?

Answer 11

RET and TRK

TG+, TTF1+, CK+, EMA+, CEA-, Calcitonin -

Calcitronin +, CEA+, TTF1+, Neuro endo +; Neurosecretory granules/amyloid

Question 12

Sialadenitis findings; what kind of crystals?

Warthin’s tumor shows on cyto?

Findings of Pleomorphic adenoma?

Answer 12

Salivary gland tissue with enlarged ducts; but not “globules” like adenoid cystic

Sialadenitis: Square crystals of amylasse

Warthin: Onococytic and lymphocytes; associated with smoking

Magenta fibrillary background and epithelial and myoepitheal cells; PLAG1 and HMGA2

Question 13

Pleomorphic adenoma has what kind of crystals?

Adenoid cystic has what cyto finding; classic clinical finding?

Most common malignant salivary gland tumor and cyto findings?
What Gene?

Answer 13

Tyrosine!; Petal shape pink crystals

Gumballs and really dark nuclei!; Also facial nerve pain or paralysis

Muco-ep: 3 cell types-glandular, intermediate, squamous
MAML2

Question 14

Adenoid cystic carcinoma mutations?

Does it have fibrillary background?

Answer 14

MYB-NIFB fusion and c-kit

No mucoid background

Question 15

Acinic cell carcinoma cyto findings?

Does it have ducts?

Answer 15

Transversing capillaries, some bare nuclei, maybe granules and cohesive

No

Question 16

Most common main salivary gland malignancy?

Gene test?

Answer 16

Muco-epidermoid

MAML2

Question 18

FIbroadenoma vs. phyloides on FNA?

What can ductal carcinoma look like?

T/F Ductal Carcinoma has more vacuoles than lobular?

Answer 18

FA: Staghorn shape with normal stroma
PT: Stag horn as well but more cellular and atypical stroma

Plasmacytoid cells; no myoeplayer seen

F: Both might have them but lobular>ductal

Question 19

“Arrowhead, teardrop” in breast is buzzword for?

Medullary Ca associations?

Answer 19

Tubular carcinoma which is very bland looking; Best prognosis

BRACA, Triple Neg, and young black women

Question 20

Funny looking “fibroadenoma” in a man?

DDx of lung cell block with froathy eosinophlic material?

Curshman spiral associations?

Answer 20

Gynecomastia; lacks terminal ductal lobules!

Pcp, Pulmonary alveolar proteinosis

Asthmatics!

Question 21

Lung Charcot Laden crystal (small pink) think?

What is a Creola body?

Immunosuppressed patient with “negative rods” spaces, think?

Answer 21

Parasities; Crystal comes from Eosinophils

Catapiller like bronchial cells with cillia bodies in asthmatics

MAC.

Question 22

“Daisy cell” on lung FNA?

Answer 22

Benign mesothelial cells especially in women!

Question 23

In urine a coffin shaped lid is, see in what kind of urine?

6 sided crystals are?

Thread like crystals are made of?

Answer 23

Triple phosphate, 3-6 sides, seen in alkaline urine, disolved in acetic acid

Cystine (Sixtine)

Tyrosine

Question 24

Ileal conduit urine finding?

Lots of columnar cells in urine, think?

Answer 24

Round ileal cells, dirty background, Globular lysosomal inclusions called Meamed Wolinska bodies

Cystitis Glandularis

Question 25

Features of high grade urothelial carcinoma? Features of low grade urothelial carcinoma?

Answer 25

High cellularity, **Coy cells (single, high N:C, irregular memrbanes)**; Birds eyes/cell death, dirty back ground, dark **nuclei and nucleoli** Loose or crowded cluster, enlarged uniform nuclei, **no nuceloi, mild N:C increase,** Clean background, Some irregular nuclear contours

Question 26

Urine polyoma virus findings? DNA or RNA virus? What Schisto causes bladder SCC?

Answer 26

Glassy smudgy inclusios (BK virus); aka Comet Cells DNA S. Haematobium, **Periapical spike** classic feature

Question 27

What is endocervicosis? Is atypia a major feature?

Answer 27

Young women with bladder symptoms **Mass on posterior wall/dome** Irregular haphazard endocervical type glands without endocervical stroma Minimal atypia

Question 28

Ugly yellow pigmented cells in males, worry or not? Refractile hooklet's seeon on liver FNA?

Answer 28

No, monster cells from seminal vesicle. Benign Hydatid cyst; Echinococcus hook worm.

Question 29

Young male with eosinophilic tumor in liver not associated with cirrhosis? Histologic features? IHC?

Answer 29

Think fibrolamellar **Stelate scar, large polygonal eosinophilic cells** Low NC ratios; rare cytoplasic modies of **fibrinogen** Lamellar fibrosis present in some cases CK7+,CK8+,CD18+, Neuroendo+, AFP-

Question 30

What organism causes cholangiocarcinoma? Cholangio staining IHC?

Answer 30

Clonorchis sinensis MOC31+, PAS+, Mucin+, pVHL+CK7+, CK19+, **pCEA (cytoplasmic)+ vs cannalicular in HCC, CK17-**

Question 31

What fungus can give calcium oxalate crystals especially in BAL? Dreaded complication? Lateral squamous lined cyst is?

Answer 31

A. Niger! Fatal pulmonary hemorrhage Branchial cleft