Random Cards for Comprehensive Exam Flashcards
What’s a way to get an idea of BP if no a-line and cuff is taking forever?
Look at EtCO2.
A sudden drop in EtCO2 would indicated a sudden drop in BP.
S/S of Parkinson’s treatments (Carbidopa/Levodopa)
Overall, think about effects of increased DA
Motor (Dyskinesias)
Psychiatric (mania, agitation, hallucunations, paranoia)
CV effects (increased contractility and HR, orthostatic hypotension)
GI (N/V d/t stimulation of CRTZ by DA)
Autonomic dysreflexia
1) Cutaneous or visceral stimulation below level of lesion 2) This activates preganglionic SNS nerves 3) Vasoconstriction below injury 4) SEVERE HTN 5) Bradycardia and vasodilation above injury
When is the peak risk for hyperkalemia with sux after spinal cord injury?
3-6 months
After acute head injury, the pt may experience a hyperdynamic circulatory response. S/S and tx of this
S/S: Increased HR, BP, and CO Arrhythmia secondary to epi surge Labetolol and esmolol are useful to treat this.
Monitors for crani for head trauma
All standard monitors Probs art-line but don’t delay crani for placement!! May or may not need CVP (to monitor hemodynamics and for VAE risk)
Monitoring best able to detect VAE
1) TEE (best) 2) Doppler 3) EtCO2
Isthmus of the thyroid is located over these trachial rings
2nd to 4th tracheal rings
Causes of hypoaldosteronism
1) Congenital deficiency 2) Hyporeninemia - May happen in long-standing DM, renal failure, or treatment with ACE-inhibitors (causes loss of angiotensin stimulation) 3) NSAIDs - May inhibit renin release and exacerbate existing renal insufficiency
S/S of Hypoaldosteronism
Severe hyperkalemia Hyperkalemic acidosis Hyponatremia Defects in cardiac conduction
Treatment for hypoaldosteronism
Mineralcorticoids (Fludrocortisone) Liberal salt intake
Nucleoside Reverse Transcriptase Inhibitors
N/V/D, myalgia, increased LFTs, renal toxicity, pancreatitis, peripheral neuropathies, BM suppression, anemia, lactic acidosis, and CYP450 inhibition Zidovudine + corticosteroids = severe myopathy, including resp. muscle inpairment
Non-Nucleoside Reverse Transcriptase Inhibitors
Delavirdine= Inhibition of CYP450 and causes increased concentration of sedatives, antiarrhythmics, warfarin, and CCBs Nevirapine induces CYP450 by 98%!
Protease Inhibitors
Ritonavir HLD, glucose intolerance, abnormal fat distribution, altered LFTs, and CYP450 inhibition!!
HIV Med CYP450 Inducers and Inhibitors
Inhibitors: - Ritonavir - Delavirdine - Zidovudine Inducer: Nevirapine
Considerations for the patient on Ritonavir
They will have more pronounced effects with Midaz and Fentanyl (start on low end of dosing) Ritonavir is a CYP450 inhibitor. Avoid MAD: Meperidine Amiodarone
Most frequent S/S of TB
Non-productive cough Weight loss Fever and night sweats Malaise Hemoptysis and chest pain (late s/s)
TB treatments and their effects
Most can cause hepatotoxicity (INH, rifampin, and pyrazinamide) Rifampin is a CYP450 inducer
SBE Prophylaxis is Recommended in these Heart Conditions
1) Damaged heart valves 2) Artificial heart valves 3) Cardiac transplant pt who develops problems with heart valves 4) Hx of endocarditis 5) HCM 6) Certain congenital malformations - Cyanotic congenital heart disease - Congenital defect that has been repaired with artificial material for the first 6 months after the procedure - A congenital problem that has been repaired, but has residual effects (persisting leak, etc)
SBE Prophylaxis is recommended in these surgical procedures
1) Dental or oral surgery, where perforation of the oral mucosa is likely 2) Respiratory tract surgery, where the resp. mucosa will likely be perforated 3) Procedures to treat infection of GI/GU tract, skin, or musculoskeletal tissue 4) Cardiac surgery 5) Hepatobiliary procedures with high risk of bacteremia
Antibiotics used for SBE prophylaxis
ACCC (Ampicillin, Cefazolin, Ceftriaxone, and Clindamycin)
What is an anaphylactoid reaction?
A reaction that isn’t antibody-mediated The drug itself causes histamine release from basophils. Size of reaction depends on how much of the agent was given and how rapidly. NMBs (sux, atra, curare, and miva), opioids (morphine and demerol), and protamine can all cause this type of reaction.
Medications that can be used to prevent anaphylactoid reactions
H1 and H2 antagonists. Corticosteroids (these cause transcription of anti-inflammatory proteins, and decrease the transcription of pro-inflammatory proteins)
Basically all anesthetics we give cause allergic reactions except
Ketamine and benzos
S/S of Anaphylaxis
- CV collapse is often the first sign (accompanied by MI and dysrhythmias) - Hypotension (50% of intravascular fluid may be lost) - Flushing - Increased PIPs or difficulty ventilating (bronchospasm) - Difficulty intubating d/t laryngeal edema Overall, think anaphylaxis with sudden hypotension and bronchoconstriction following drug administration
What should you do if your patient has an LMA in place and you suspect anaphylaxis?
Remove that shit and intubate!! They will have bronchoconstriction and need assistance ventilating. If you wait, they can develop laryngeal edema and cause a difficult intubation.
Volume replacement in anaphylaxis
Colloids preferred d/t leaky capillaries Colloid replacement: 10mL/kg Crystalloid: 10-25mL/kg
Basic interventions in anaphylaxis
Stop offending drug Communicate to the surgeon what is happening Administer 100% O2 Intubate if haven’t done so already Elevate legs Give fluids (10-25mL/kg) Give epinephrine (10mcg-1mg –> start low if just suspecting anaphylaxis, and see how they respond) - If resistant to epi, try Glucagon, Norepi, or Vasopressin Second-line pharmacology: - B2 agonists (albuterol and terbutaline) - H1&2 antagonists (better for prevention than actual treatment) - Corticosteroids (hydrocortisone 250mg IV) –> corticosteroids work by enhancing the B effect of other agents and inhibiting arachidonic acid release
What is the best regional technique in the septic patient?
PSYCH! Regional anesthesia is contraindicated in sepsis.
This is the only anesthetic gas that is consistently teratogenic
N2O. Increases the rate of spontaneous abortions and causes birth defects. (remember that it inhibits enzymes responsible for DNA synthesis and myelin formation)
Effect of gases other than N2O
Studies are inconclusive