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Question 1

Why does propofol cause pain on injection?

Answer 1

phenol

Question 2

Therapeutic Index

Answer 2

LD 50/ ED 50

Question 3

Therapeutic Window

Answer 3

TD 50/ ED 50

Question 4

Which NMBD has the fastest onset and is less potent?

Answer 4

rocuronium

Question 5

What does the dose response curve tell us?

Answer 5

potency and efficacy

Question 6

what are our phenylpiperidines?

Answer 6

fentanyl, sufentanil, alfentanil, and remifentanil

Question 7

properties of an ideal IV anesthetic? (seven of them)

Answer 7

water soluble, minimal CV effects and respiratory depression, lack hypersensitivity reactions, rapid onset of action, rapidly metabolized, produce steep dose response curve, quick return to mental baseline

Question 8

which drug has most of the ideal properties?

Answer 8

propofol

Question 9

which receptor do IV anesthetics and benzodiazepines attach?

Answer 9

GABA receptor (gammaminobutyric acid) which is a ligand gated ion channel
when activated flood of Cl- comes in and hyperpolarizes the cell (inhibitory response)

Question 10

What is the dissociation constant?

Answer 10

the pH at which 50% is ionized and 50% is nonionized

Question 11

Context sensitive half time

Answer 11

(continuous infusion) time required for an infusion maintained at a constant concentration to decrease by 50% (increases with longer infusions)