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PSBIM: Hematology > Random > Flashcards

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1
Q 
Which of the following occurs due to abnormal iron metabolism?
A. Renal Diseae
B. Inflammation
C. Hypometabolic states
D. All of the above
A

Inflammation and IDA

The rest are due to suboptimal EPO respone to anemia

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2
Q 
Iron requirement is increased during?
A. Adulthood
B. Adolescence
C. 1st trimester of pregnancy
D. All of the above
A

B.

Iron requirement is increased during the last 2 trimesters of pregnancy, infancy, chilhood and adolescence

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3
Q 
Principal iron regulatory hormone
A. Ferrureductase
B. Hepcidin
C. Herroxidase
D.
A

B. Hepcidin (from the liver which regulates the transporter Ferroportin)

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4
Q 
Which of the following will be increased in IRON deficient states?
A. TSAT
B. S. Iron
C. TIBC
D. S ferritin
A

TIBC abd Protoporphyrin

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5
Q 
Which of the following causes of iron deficiency is due to decreased iron intake, absorption, or use?
A. Rapid growth in adolescence
B. Acute or chronic inflammaiton
C. EPO therapy
D. Pregnancy
A

B

The rest is due to increased demand for iron/hematopoeisis

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6
Q 
Which of the following is responsible for decreasing EPO production in anemia of inflammation?
A. IL -1
B. TNF
C. Hepcidin
D. Interferon gamma
A

A.

All choices are involved in the mechanism of anemia in chronic/acute inflammation

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7
Q 
Which of the following is responsible for suppressing response to EPO in anemia of inflammation?
A. IL -1
B. TNF
C. Hepcidin
D. Interferon gamma
A

Interferon Gamma
*interferes response

All choices are involved in the mechanism of anemia in chronic/acute inflammation

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8
Q 
Which of the following is increased in inflammation and serves to inhibit iron absorption and iron release from storage site?
A. IL -1
B. TNF
C. Hepcidin
D. Interferon gamma
A

Hepcidin

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9
Q 
You encounter a patient on EPO however there seems to be a decrease in Hgb while on treatment, which of the following will you consider?
A. Lead toxicity
B. Iron toxicity
C. Aluminum toxicity
D. Copper toxicity
A

Consider Aluminum toxicity

Others: Infection, iron DEPLETION, hyperparathyroidism

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10
Q

Which of the following regarding 2,3- BPG is incorrect?
A. Lowers oxygen affinity when bound to hemoglobin
B. HbA has a reasonably high affinity to 2,3 - BPG
C. An increase in 2,3 BPG leads to more O2 being delivered
D. None of the above

A

D. All are true

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11
Q

Most common genetic disorder in the world?

A

Thalassemia

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12
Q 
The following are indications for prophylaxis with Folic acid except?
A. Chronic dialysis
B. Gastric surgery
C. Pregnancy
D. TPN
A

Gastric surgery is one of the indications for Cobalamin supplmentation

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13
Q 
Which of the following is a test to confirm celiac disease
A. Transaminase
B. Transglutamate
C. Transferase
D. Transglutaminase
A

Transglutaminase

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14
Q

Common feature in megaloblastic anemia

A

Defect in DNA synthesis

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15
Q 
Which of the following is not a feature of Megaloblastc anemia?
A. Melanin skin hyperpigmentation
B. Glossitis
C. High fever
D. Angular cheilosis
A

Fever- is just mild

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16
Q 
Maternal deficiency in folate deficiency (no cobalamin deficiency)
A. Recurrent fetal loss
B. Neural tube defects
C. Prematurity
D. All of the above
A

Prematurity

A and B occur with BOTH folate and cobalamin deficiency

17
Q

Which of the causes of megaloblastic anema is related to neurologic changes?

A

Cobalamin

18
Q 
Which of the following is causes of Hemolytic anemias is due to an acquired intracorpuscular defect?
A. Micorangiopathy
B. Toxic agents
C. Paroxysmal nocturnal hemoglobinuria
D. Autoimmune
A

PNH

The others are acquired EXTRAcorpuscular factors

19
Q 
Which of the following causes of Hemolytic anemia is due to a hereditary extracorpuscular defect?
A. Membrane cystoskeletal defects
B. Hemoglobinopathies
C. Enzymopathies
D. Atypical HUS
A

Atypical/ Familial HUS

The rest are heridtary INTRA corpuscular defects

20
Q 
Main sign of Hemolytic anemia
A. Pallor
B. Jaundice
C. Bossing of skull
D. Splenomegaly
A

Jaundice

All are features common to most patients with hemolytic disorders

21
Q 
Which of the following will be reduced in Hemolytic anemia?
A. Reticulocytes
B. Haptoglobin
C. LDH
D. MCV
A

Haptoglobin- this a plasma protein produced in the liver that forms a complex with hemoglobin in the blood. When RBC ruptures and releases Hgb a Haptoglobin- Hgb complexes is formed which is taken up by macrophages leading to the decrease.

The rest will be increased

22
Q 
Which of the following causes of hemolysis is due to Complement mediated destruction of CD 59  negative cells
A. Mismatched blood transfusion
B. Paroxysmal Nocturnal Hemoglobinuria
C. Favism
D.  March hemoglobinuria
A

Paroxysmal Nocturnal Hemoglobinuria

23
Q 
Which of the following causes of hemolysis is due to mechanical destruction?
A. Mismatched blood transfusion
B. Paroxysmal Nocturnal Hemoglobinuria
C. Favism
D.  March hemoglobinuria
A

March hemoglobinuria

24
Q 
Which of the following causes of hemolysis is due to destruction of older fractin of G6PD deficient red cells
A. Mismatched blood transfusion
B. Paroxysmal Nocturnal Hemoglobinuria
C. Favism
D.  March hemoglobinuria
A

Favism

25
Q 
Which of the following is the approprate diagnostic procedure for PNH?
A. Flow cytometry
B. Test for Donath Landsteiner antibody
C. Targteted history taking
D. G6PD assay
A

Flow cytometry for a CD 59 (-) cell

26
Q 
Which of the following is the approprate diagnostic procedure for Paroxysmal cold hemoblobinuria
A. Flow cytometry
B. Test for Donath Landsteiner antibody
C. Targteted history taking
D. G6PD assay
A

Donath Landsteiner antibody

27
Q 
Which of the following is the approprate diagnostic procedure for Favism
A. Flow cytometry
B. Test for Donath Landsteiner antibody
C. Targteted history taking
D. G6PD assay
A

G6PD

28
Q 
Which of the following is the approprate diagnostic procedure for March hemoglobinuria 
A. Flow cytometry
B. Test for Donath Landsteiner antibody
C. Targteted history taking
D. G6PD assay
A

C

29
Q 
Which of the following causes of hemolysis is related to a history of intense history of playing bongo drums?
A. Mismatched blood transfusion
B. Paroxysmal Nocturnal Hemoglobinuria
C. Favism
D.  March hemoglobinuria
A

D.

Also related to marathon runnig and prolonged barefoot ritual dancing

30
Q 
Which of the following causes of hemolysis is seen with regurgitant proesthetic heart valves
A. PCH
B. Paroxysmal Nocturnal Hemoglobinuria
C. Favism
D.  Microangiopathy
A

D

31
Q 
Which of the following will have CD34 bearing cells?
A. Myelophthisic anemia
B. Myelodysplastic syndrome
C. Pure Red Cell aplasia
D. Aplastic anemia
A

Aplastic anemia

32
Q 
Which of the following will have giant pronormbolast in the blood smear?
A. Myelophthisic anemia
B. Myelodysplastic syndrome
C. Pure Red Cell aplasia
D. Aplastic anemia
A

Pure Red Cell Aplasia

33
Q 
Children with Down’s syndrome are susceptible to which of the following?
A. Myelophthisic anemia
B. Myelodysplastic syndrome
C. Pure Red Cell aplasia
D. Aplastic anemia
A

Myelodysplastic syndrome

34
Q 
Which of the following is Related to Sweet’s syndrome?
A. Myelophthisic anemia
B. Myelodysplastic syndrome
C. Pure Red Cell aplasia
D. Aplastic anemia
A

Myelodysplastic syndrome

35
Q 
Which of the following will have a PBS picture called leukoeryhtoblastosis?
A. Myelophthisic anemia
B. Myelodysplastic syndrome
C. Pure Red Cell aplasia
D. Aplastic anemia
A

Myelophthisic leukoerythroblastosis

PSBIM: Hematology (2 decks)

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