Random Flashcards
Which of the following occurs due to abnormal iron metabolism? A. Renal Diseae B. Inflammation C. Hypometabolic states D. All of the above
Inflammation and IDA
The rest are due to suboptimal EPO respone to anemia
Iron requirement is increased during? A. Adulthood B. Adolescence C. 1st trimester of pregnancy D. All of the above
B.
Iron requirement is increased during the last 2 trimesters of pregnancy, infancy, chilhood and adolescence
Principal iron regulatory hormone A. Ferrureductase B. Hepcidin C. Herroxidase D.
B. Hepcidin (from the liver which regulates the transporter Ferroportin)
Which of the following will be increased in IRON deficient states? A. TSAT B. S. Iron C. TIBC D. S ferritin
TIBC abd Protoporphyrin
Which of the following causes of iron deficiency is due to decreased iron intake, absorption, or use? A. Rapid growth in adolescence B. Acute or chronic inflammaiton C. EPO therapy D. Pregnancy
B
The rest is due to increased demand for iron/hematopoeisis
Which of the following is responsible for decreasing EPO production in anemia of inflammation? A. IL -1 B. TNF C. Hepcidin D. Interferon gamma
A.
All choices are involved in the mechanism of anemia in chronic/acute inflammation
Which of the following is responsible for suppressing response to EPO in anemia of inflammation? A. IL -1 B. TNF C. Hepcidin D. Interferon gamma
Interferon Gamma
*interferes response
All choices are involved in the mechanism of anemia in chronic/acute inflammation
Which of the following is increased in inflammation and serves to inhibit iron absorption and iron release from storage site? A. IL -1 B. TNF C. Hepcidin D. Interferon gamma
Hepcidin
You encounter a patient on EPO however there seems to be a decrease in Hgb while on treatment, which of the following will you consider? A. Lead toxicity B. Iron toxicity C. Aluminum toxicity D. Copper toxicity
Consider Aluminum toxicity
Others: Infection, iron DEPLETION, hyperparathyroidism
Which of the following regarding 2,3- BPG is incorrect?
A. Lowers oxygen affinity when bound to hemoglobin
B. HbA has a reasonably high affinity to 2,3 - BPG
C. An increase in 2,3 BPG leads to more O2 being delivered
D. None of the above
D. All are true
Most common genetic disorder in the world?
Thalassemia
The following are indications for prophylaxis with Folic acid except? A. Chronic dialysis B. Gastric surgery C. Pregnancy D. TPN
Gastric surgery is one of the indications for Cobalamin supplmentation
Which of the following is a test to confirm celiac disease A. Transaminase B. Transglutamate C. Transferase D. Transglutaminase
Transglutaminase
Common feature in megaloblastic anemia
Defect in DNA synthesis
Which of the following is not a feature of Megaloblastc anemia? A. Melanin skin hyperpigmentation B. Glossitis C. High fever D. Angular cheilosis
Fever- is just mild
Maternal deficiency in folate deficiency (no cobalamin deficiency) A. Recurrent fetal loss B. Neural tube defects C. Prematurity D. All of the above
Prematurity
A and B occur with BOTH folate and cobalamin deficiency
Which of the causes of megaloblastic anema is related to neurologic changes?
Cobalamin
Which of the following is causes of Hemolytic anemias is due to an acquired intracorpuscular defect? A. Micorangiopathy B. Toxic agents C. Paroxysmal nocturnal hemoglobinuria D. Autoimmune
PNH
The others are acquired EXTRAcorpuscular factors
Which of the following causes of Hemolytic anemia is due to a hereditary extracorpuscular defect? A. Membrane cystoskeletal defects B. Hemoglobinopathies C. Enzymopathies D. Atypical HUS
Atypical/ Familial HUS
The rest are heridtary INTRA corpuscular defects
Main sign of Hemolytic anemia A. Pallor B. Jaundice C. Bossing of skull D. Splenomegaly
Jaundice
All are features common to most patients with hemolytic disorders
Which of the following will be reduced in Hemolytic anemia? A. Reticulocytes B. Haptoglobin C. LDH D. MCV
Haptoglobin- this a plasma protein produced in the liver that forms a complex with hemoglobin in the blood. When RBC ruptures and releases Hgb a Haptoglobin- Hgb complexes is formed which is taken up by macrophages leading to the decrease.
The rest will be increased
Which of the following causes of hemolysis is due to Complement mediated destruction of CD 59 negative cells A. Mismatched blood transfusion B. Paroxysmal Nocturnal Hemoglobinuria C. Favism D. March hemoglobinuria
Paroxysmal Nocturnal Hemoglobinuria
Which of the following causes of hemolysis is due to mechanical destruction? A. Mismatched blood transfusion B. Paroxysmal Nocturnal Hemoglobinuria C. Favism D. March hemoglobinuria
March hemoglobinuria
Which of the following causes of hemolysis is due to destruction of older fractin of G6PD deficient red cells A. Mismatched blood transfusion B. Paroxysmal Nocturnal Hemoglobinuria C. Favism D. March hemoglobinuria
Favism
Which of the following is the approprate diagnostic procedure for PNH? A. Flow cytometry B. Test for Donath Landsteiner antibody C. Targteted history taking D. G6PD assay
Flow cytometry for a CD 59 (-) cell
Which of the following is the approprate diagnostic procedure for Paroxysmal cold hemoblobinuria A. Flow cytometry B. Test for Donath Landsteiner antibody C. Targteted history taking D. G6PD assay
Donath Landsteiner antibody
Which of the following is the approprate diagnostic procedure for Favism A. Flow cytometry B. Test for Donath Landsteiner antibody C. Targteted history taking D. G6PD assay
G6PD
Which of the following is the approprate diagnostic procedure for March hemoglobinuria A. Flow cytometry B. Test for Donath Landsteiner antibody C. Targteted history taking D. G6PD assay
C
Which of the following causes of hemolysis is related to a history of intense history of playing bongo drums? A. Mismatched blood transfusion B. Paroxysmal Nocturnal Hemoglobinuria C. Favism D. March hemoglobinuria
D.
Also related to marathon runnig and prolonged barefoot ritual dancing
Which of the following causes of hemolysis is seen with regurgitant proesthetic heart valves A. PCH B. Paroxysmal Nocturnal Hemoglobinuria C. Favism D. Microangiopathy
D
Which of the following will have CD34 bearing cells? A. Myelophthisic anemia B. Myelodysplastic syndrome C. Pure Red Cell aplasia D. Aplastic anemia
Aplastic anemia
Which of the following will have giant pronormbolast in the blood smear? A. Myelophthisic anemia B. Myelodysplastic syndrome C. Pure Red Cell aplasia D. Aplastic anemia
Pure Red Cell Aplasia
Children with Down’s syndrome are susceptible to which of the following? A. Myelophthisic anemia B. Myelodysplastic syndrome C. Pure Red Cell aplasia D. Aplastic anemia
Myelodysplastic syndrome
Which of the following is Related to Sweet’s syndrome? A. Myelophthisic anemia B. Myelodysplastic syndrome C. Pure Red Cell aplasia D. Aplastic anemia
Myelodysplastic syndrome
Which of the following will have a PBS picture called leukoeryhtoblastosis? A. Myelophthisic anemia B. Myelodysplastic syndrome C. Pure Red Cell aplasia D. Aplastic anemia
Myelophthisic leukoerythroblastosis
