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Question 1

What is the commonest inherited bleeding disorder?

Answer 1

Von-Willebrand disorder

Question 2

Target cells, Howell-Jolly bodies, pappenheimer bodies are features on a blood film that would be seen in what condition?

Answer 2

Hyposplenism

Question 3

Target cells and ‘pencil’ poikilocytes are blood films finding typical of what?

Answer 3

Iron deficiency anaemia

Question 4

‘Tear-drop’ poikilocytes is a blood film finding typical of what?

Answer 4

Myelofibrosis

Question 5

What are the 2 empirical antibiotics for neutropenic sepsis?

Answer 5

IV piperacillin and tazobactam

Question 6

What is a myeloma a cancer of?

Answer 6

Plasma cells

Question 7

What proteins are commonly found in the urine of someone with myeloma?

Answer 7

Bence Jones proteins

Question 8

What may be seen on xray/MRI in someone with myeloma?

Answer 8

Osteolytic lesions, rain drop skull

Question 9

What may be seen on a peripheral blood smear in someone with myeloma?

Answer 9

Rouleaux formation (stacking of blood cells on top of eachother)

Question 10

Name 2 features of myeloma

Answer 10

• Hypercalcaemia
• Renal impairment
• Anaemia
• Increased infections
• Bone pain especially back
• Thrombocytopenia which increases bleeding risk

Question 11

What mutation is associated with polycythaemia vera?

Answer 11

JAK2

Question 12

Pigmented gallstones are associated with which cause of anemia?

Answer 12

Sickle cell anaemia

Question 13

After a blood transfusion reaction, what is the most concerning sign implying a serious infection?

Answer 13

Hypotension

Question 14

What blood profile is considered the universal donor?

Answer 14

AB Rh negative

Question 15

What is given to patients with polycythaemia vera to decrease chances of clots forming?

Answer 15

Aspirin

Question 16

Name 3 features of polycythaemia vera

Answer 16

• Pruritus especially after hot bath
• Hypertension
• Low ESR
• Splenomegaly
• Increased thrombosis risk

Question 17

What is the management of idiopathic thrombocytopenic purpura?

Answer 17

Steroids

Question 18

A sudden anaemia and low reticulocyte count in sickle cell anaemia indicates what infection?

Answer 18

Parvovirus

Question 19

How is sickle cell anaemia diagnosed?

Answer 19

Hb electrophoresis

Question 20

What paraprotein (Ig) is most commonly found in multiple myeloma?

Answer 20

IgG

Question 21

What medication should be prescribed before starting chemo to reduce the likelihood of tumour lysis syndrome?

Answer 21

Rasburicase or allopurinol

Question 22

Generally what’s the transfusion threshold re. platelets?

Answer 22

<70g\L in fit individuals, <80 in px with IHD