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Transudative effusions:
- pH
- protein
- LDH
7.4 - 7.55
low pleural/serum protein (<0.5) AND
low pleural/serum LDH (<0.6) AND
Pleural LDH < 2/3 upper limit of normal serum LDH
Exudative effusions:
- pH
- protein
- LDH
7.3 - 7.45
high pleural/serum protein (>0.5) OR
high pleural/serum LDH (>0.6) OR
Pleural LDH > 2/3 upper limit of normal serum LDH
indications for TB pleural effusion
- adenosine deaminase
- protein >4
complicated vs uncomplicated bacterial pleural effusions
- pH
- glucose
- WBCs
- LDH
uncomplicated (pH >7.2)
complicated (pH <7.2)
uncomplicated (glucose >60)
complicated (glucose <60)
uncomplicated (WBCs <50,000)
complicated (WBCs >50,000)
uncomplicated (LDH <1,000)
complicated (LDH >1,000)
hypovolemic shock:
- preload
- PCWP
- CI
- SVR
- preload: decreased
- PCWP: decreased
- CI: decreased
- SVR: increased (sympathetic NS increased)
Cardiogenic shock
- preload
- PCWP
- CI
- SVR
- preload: increased
- PCWP: increased
- CI (decreased)
- SVR (increased)
obstructive shock
- preload
- PCWP
- CI
- SVR
- preload: increased
- PCWP: decreased
- CI: decreased
- SVR: increased
distributive shock
- preload
- PCWP
- CI
- SVR
- preload: decreased
- PCWP: decreased
- CI: increased (can decreased in LATE septic shock)
- SVR: decreased
- preload: decreased
- PCWP: decreased
- CI: decreased
- SVR: increased (sympathetic NS increased)
hypovolemic shock
- preload: increased
- PCWP: increased
- CI (decreased)
- SVR (increased)
cardiogenic shock
- MI
- preload: increased
- PCWP: decreased
- CI: decreased
- SVR: increased
obstructive shock
- PE
- preload: decreased
- PCWP: decreased
- CI: increased
- SVR: decreased
distributive shock
- sepsis
complications within 3-5 days after MI
papillary muscle rupture
interventricular septum rupture
complications within 5 days - 2 weeks after MI
free wall rupture
complications several months after MI
left ventricular aneurysm
hallmark of left ventricular aneurysm after MI
deep Q waves and persistently elevated ST segments
biopsy findings with microscopic colitis
mononuclear infiltrate within lamina propria
two types of microscopic colitis
1) collagenous
- thickened subepithelial collagen band
2) lymphocytic
- intraepithelial lymphocytes
pharm tx for hepatic encephalopathy
lactulose (reduce serum ammonium)
rifamixin (non-absorbable antibiotic)
causes of bloody ascites
trauma
malignancy
TB (rarely)
causes of milky ascites
chylous (rich in triglycerides, due to presence of thoracic or intestinal lymph in abdominal cavity)
causes of turbid ascites
possible infection
causes of straw color ascites
more likely benign causes
neutrophils >250/mm3 in ascites
bacterial perotonitis
calculating SAAG
serum albumin - ascites albumin
SAAG >1.1 causes
higher protein in the serum
portal hypertension
- cardiac ascites
- cirrhosis
- Budd chiari
SAAG <1.1 causes
higher protein in the ascitic fluid
- TB
- peritoneal cancer
- pancreatic
- nephrotic syndrome
breastfeeding (lactation failure) vs breast milk jaundice
breastfeeding: age <1 week
- insufficient intake of breast milk causing delayed stooling and and increase in enterohepatic circulation of bilirubin
breast milk: age >1 week
- increased B-glucuronidase in the breast milk causing increased deconjugation of intestinal bilirubin and increased enterohepatic circulation