Raised intracranial pressure Flashcards

1
Q

List the risk factors for raised intracranial pressure.

A
  • Mass lesions e.g. haematoma, tumour, abscess
  • Focal or diffuse oedema or swelling e.g. infarction, trauma, tumour, encephalitis, meningitis, diffuse head injury, SAH, Reye’s syndrome, hypertensive encephalopathy.
  • Disturbance of CSF circulation e.g. hydrocephalus (obstructive and comminicating), benign intracranial hypertension, choroid plexus papilloma
  • Increased cerebral blood volume e.g. vasodilation (hypercapnia), venous outflow obsruction, venous sinus thrombosis
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2
Q

What criteria is used to diagnose IIH?

A

Modified Dandy criteria (for IIH):

  • Signs and symptoms of raised ICP
  • CSF opening pressure of ≥25 cm H2O
  • No localising neurological signs
  • Patient awake and alert
  • No deformity, displacement or obstruction of ventricles and normal imaging (except for raised ICP signs)
  • No cause for the raised ICP
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3
Q

What is the normal ICP?

A

0-135mm CSF (7-15mmHg in the supine position)
Small increases in CSF volume may be accommodated by CSF expulsion to the lumbar theca.

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4
Q

What are some signs of raised intracranial pressure on imaging?

A
  • Empty sella
  • Venous stenoses
  • Globe flattening
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5
Q

What factors affect cerebral vascular resistance?

A

Chemoregulation e.g. reduction of ICP with hyperventilation by reduing blood flow
Autoregulation - maintains cerebral blood flow by vasoconstriction and vasodilation

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6
Q

How much CSF is produced per day? Where is it absorbed?

A

500ml - mainly by choroid plexus of the later, third and fourth ventricles
Absorbed in the arachnoid granulations to enter the venous system.

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7
Q

What are the clinical features of raised ICP?

A
  • Headache - worse on coughing, nocturnal
  • Vomiting - projectile as ICP rises
  • Visual disturbance e.g. blurring, obscurations (transient blindness), papilloedema, retinal haemorrhages (if rise was rapid)
  • Pupillary irregularities
  • Fundoscopy showing blurring of disc margins, loss of venous pulsations
  • 3rd or 6th nerve palsies
  • Cushing’s triad = widening pulse pressure, braducardia, irregular breathing
  • Seizure
  • Cushing’s peptic ulceration
  • Slowly increasing head size in infants
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8
Q

What does a gradual dilatation of a pupil after injury suggest?

A

Gradual dilatation and decreasing responsiveness to light = expansion of a clot over the ipsilateral hemisphere

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9
Q

How can you monitor the ICP?

A

Ventricular catheter or surface pressure recording device
Usuallly started when pressure exceeds 30mmHg

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10
Q

What are some treatment options for reducing intracranial pressure?

A

Investigate and treat the underlying cause
Head elevation to 30 degrees
Hyperosmolar therapy e.g. IV mannitol is an osmotic duiretic, ?hypertonic saline.
Sedation and paralysis
Controlled hyperventilation - aim is to reduce pCO2 → vasoconstriction of the cerebral arteries → reduced ICP. This causes a rapid but temporary lowering of ICP. Caution with reducing flow to ischaemic parts of brain
Hypothermia - cooling to 35 degrees
Steroids - good for tumour related raised ICP
CSF removal - drain from intraventricular monitor, repeat LPs or ventriculoperitoneal shunt
Surgery -e.g. burr hole for external drain, decompressive craniectomy

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11
Q

What is the cerebral perfusion pressure calculation?

A

CPP = mean arterial pressure - ICP

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12
Q

What investigations would you do in raised ICP?

A

MRI/CT head - find underlying cause
Invasive ICP monitoring- lateral ventricular catheter is inserted, small amounts of CSF may also be drained
>20mmHg - usually requires further treatment

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