Radiotherapy Flashcards
What is the improved outcome of either additional neo adjuvant or adjuvant radiotherapy compared with surgery alone?
Reduced risk of local recurrence.
No definite evidence of improved overall survival.
Which trials demonstrates reduced risk of local recurrence by 50% with short course pre operative RTx for rectal ca?
But no difference in overall survival
Dutch TME and MRC CR07
What is the effect of adding 5FU/LV to long course RTx for local recurrence?
Halved the risk of local recurrence but had no impact on overall survival.
What led to the shift from post operative to pre operative chemoradiotherapy?
German Rectal cancer group demonstrated a lower rate of local recurrence and acute/late toxicity in favour of pre operative CRT. Though no difference in overall survival.
