Radiation Therapy and Aggressiveness of Cancers Flashcards
What are late effects of radiation therapy?
Infertility, cardiac toxicity, second cancers.
What is the median survival for Stage IV NSCLC?
12-14 months
All-comers, being treated with just chemotherapy, chemo + IO, Targeted therapies
What does performance status indicate?
A patient’s level of functioning and ability to care for themselves.
Indicator of how well a patient may tolerate cancer treatments, and plays a role in prognosticating.
What is prognosis of advanced NSCLC when no treatment is pursued?
Non-Small Cell Lung Cancer
Less than 6 months
Highly v. Lesser Aggressive Cancer
Pancreatic cancer
Highly Aggressive
Highly v. Lesser Aggressive Cancer
Metastatic NSCLC without targetable molecular drivers, low PDL-1 expression
Highly Aggressive
Highly v. Lesser Aggressive Cancer
Metastatic triple negative breast cancer
Highly Aggressive
Highly v. Lesser Aggressive Cancer
Glioblastoma
Highly Aggressive
Highly v. Lesser Aggressive Cancer
Extensive stage SCLC – initial rapid response to treatments but overall, not curable
Highly Aggressive
Highly v. Lesser Aggressive Cancer
Advanced Stage Melanoma
Highly Aggressive
Highly v. Lesser Aggressive Cancer
Angiosarcoma or certain high-grade soft tissues sarcomas
Highly Aggressive
Highly v. Lesser Aggressive Cancer
Esophageal/Stomach cancers
Highly Aggressive
Highly v. Lesser Aggressive Cancer
Cholangiocarcinoma
Highly Aggressive
Highly v. Lesser Aggressive Cancer
High grade ovarian cancer (high-grade serous carcinoma)
Highly Aggressive
Highly v. Lesser Aggressive Cancer
Castrate sensitive prostate cancer
Less Aggressive
Highly v. Lesser Aggressive Cancer
Breast Cancer with ER+/PR+ hormone expression
Less Aggressive
Highly v. Lesser Aggressive Cancer
Thyroid cancer (papillary/follicular subtypes)
Less Aggressive (can eventually develop to moderate aggressiveness due to resistance to therapies)
Highly v. Lesser Aggressive Cancer
Basal Cell Carcinoma
Less Aggressive
Highly v. Lesser Aggressive Cancer
Carcinoid tumors
Less Aggressive
Highly v. Lesser Aggressive Cancer
Low-grade meningiomas
Less Aggressive
Highly v. Lesser Aggressive Cancer
GI stromal tumors (GIST, low risk subtype)
Less Aggressive
What are acute side effects of radiation therapy to the abdomen?
Nausea, Vomiting, Diarrhea
Tissues swell during the treatment, so can have side effects related to edema. These are all temporary, improves once the tissue swelling goes down and healing occurs.
What are acute side effects of radiation therapy to the head & neck?
Mucositis, Pain
What are acute side effects of radiation therapy to the Thorax?
Esophagitis
Tissues swell during the treatment, so can have side effects related to edema. These are all temporary, improves once the tissue swelling goes down and healing occurs.
What are acute side effects of radiation therapy to the Pelvis?
Bowel / Bladder changes
Tissues swell during the treatment, so can have side effects related to edema. These are all temporary, improves once the tissue swelling goes down and healing occurs.
What are acute side effects to radiation therapy?
Fatigue, pain
Depends on location radiation is being delivered for other focal symptoms.
