Radiation Biology Flashcards
SI (International Unit)
a conventional unit that measures the dose of radiation absorbed by a person (deposited in the human tissue)
Kerma (Gy)
Kinetic Energy Released in MAtter measures exposure in the air
kinetic energy transferred from photons to electrons.
Conventional unit rad or SI unit gray (Gy) measures what?
Amount of energy deposited in human tissue.
The biological risk of exposure to radiation is measured using which units?
Conventional: rem
SI Unit: sievert (Sv)
Equivalent dose (Sv)
Compares the biologic effects of different types of radiation on tissue or organ.
Effective Dose (E)
the effective dose is used to estimate the risk in humans.
Radiobiology
the study of the effects of ionizing radiation on living systems.
Direct exposure
Can cause free radicals
Indirect exposure
formation of organic free radicals
Free radical
Water interacts with x-ray photons and biologic molecules.
Water is converted into hydrogen and hydroxyl free radicals.
free radicals are toxin to tissues.
Most important type of DNA change
the breakage of double-strand DNA.
can lead to cell killing, carcinogenesis and heritable effects.
Deterministic effect
Radiation injury causing injury of large number of cells.
Stochastic effect
Sublethal affect results to cancer formation, or heritable mutation.
ex. leukemia
What plays a major role in cell death?
Caspases
What gene is responsible for apoptosis?
p53