Radiation Biology Flashcards
SI (International Unit)
a conventional unit that measures the dose of radiation absorbed by a person (deposited in the human tissue)
Kerma (Gy)
Kinetic Energy Released in MAtter measures exposure in the air
kinetic energy transferred from photons to electrons.
Conventional unit rad or SI unit gray (Gy) measures what?
Amount of energy deposited in human tissue.
The biological risk of exposure to radiation is measured using which units?
Conventional: rem
SI Unit: sievert (Sv)
Equivalent dose (Sv)
Compares the biologic effects of different types of radiation on tissue or organ.
Effective Dose (E)
the effective dose is used to estimate the risk in humans.
Radiobiology
the study of the effects of ionizing radiation on living systems.
Direct exposure
Can cause free radicals
Indirect exposure
formation of organic free radicals
Free radical
Water interacts with x-ray photons and biologic molecules.
Water is converted into hydrogen and hydroxyl free radicals.
free radicals are toxin to tissues.
Most important type of DNA change
the breakage of double-strand DNA.
can lead to cell killing, carcinogenesis and heritable effects.
Deterministic effect
Radiation injury causing injury of large number of cells.
Stochastic effect
Sublethal affect results to cancer formation, or heritable mutation.
ex. leukemia
What plays a major role in cell death?
Caspases
What gene is responsible for apoptosis?
p53
Dose rate vs exposure rate
High dose rate causes more damage than exposure to the same total dose given at a lower dose rate.
Radiosensitive oral malignant tumors
squamous cell carcinoma
ALARA
As low as reasonably achievable
Which structure is radiopaque?
Lamina dura
Which structure is radiolucent?
PDL
Mandibular canals
X-rays and pregnant women
Take only necessary x-rays
If patient has poor hygiene which type of x-rays should dentist order?
FMX
Red XCP is used for
bitewings
If patient has excellent hygiene which x-ray would you order?
bitewings
PA’s are useful for which procedure
RCT
How many PA’s and bitewings in an FMX
14 PA’s
4 bitewings