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Jo Flashcardlet Decks > RACP > Flashcards

RACP Flashcards

1
Q

Crizotinib

A

EML 4 ALK inhibitorNSCLC

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2
Q

Abiratarone

A

castrate resistant prostate Cablocks tumour androgen productionneed to give w pred to avoid ACTH surge

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3
Q

GnRH antagonist

A

zoladex

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4
Q

anti androgen

A

flutamidecan try to withdraw if castrate resistant prostate Ca - 20% will improve

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5
Q

p16

A

marker for HPV head and neck cancerif present - do better

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6
Q

gefitinib

A

EGFR TKI used in EGFR mutant NSCLC

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7
Q

bevacizumab

A

VEGF inhibitorSE - HTN, proteinuria

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8
Q

lambrolizumab

A

PD1 inhibitor for metastaic melanoma

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9
Q

Ipilumimab

A

CTLA4 blockerused in metastatic melanomaSE - colitis, hepatitis, rash, hypopit (rare)

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10
Q

Vemurafenib and dabrafenib

A

used in BRAF mutant melanomaSE - SCCsphosphoERK – if increased, sign of BRAF inhibitor resistance / disease progression

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11
Q

Penatumimab and cetuximab

A

EGFRmabs used in Kras wild type NSCLC/CRCSE - acne rash (treat w doxy and pred)

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12
Q

seminoma treatment

A

Alpha fetoprotein should NOT be elevatedRtx sensitiveOrchidectomy + active surveillance if early stage

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13
Q

non seminoma treatment

A

AFP is the markerNeed to look for retroperitoneal disease, and if present – retroperitoneal LN dissection Chemotx sensitive

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14
Q

SCLC

A

Chemotx sensitiveIf in one area/field – chemotx + radtx

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15
Q

NSCLC

A

Rtx responsiveIf resectable – removeIf not – stereotactic rtx

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16
Q

Rifampicin

A

inhibits bacterial DNA dependent RNA polymerase preventing transcription of DNA into mRNASE - orange secretions, flu like sx, hepatits

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17
Q

Ethambutol

A

inhibits the enzyme arabinosyl transferase SE - optic neuritis

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18
Q

Pyrazinamide

A

inhibits fatty acid synthase (FAS) ISE - gout / hyperuricaemia, hepatitis

19
Q

Isoniazid

A

inhibits mycolic acid synthesisSE - peripheral neuropathy (need to give Vitamin B6), hepatitis, agranulocytosis

20
Q

Type I Hypersensitivity

A

Anaphylactic:antigen reacts with IgE bound to mast cellsanaphylaxis, atopy e.g. asthma, eczema and hayfever

21
Q

Type II Hypersensitivity

A

Cell bound:IgG or IgM binds to antigen on cell surfaceeg AHA, ITP, Goodpasture’s, acute hemolytic transfusion reactions, bullous pemphigoid, pemphigus vulgaris

22
Q

Type III Hypersensitivity

A

Immune complex:Free antigen and antibody (IgG, IgA) combineeg serum sickness, SLE, post strep GN

23
Q

Type IV Hypersensitivity

A

Delayed:T cell mediatedEg - tuberculin skin reaction, GVHD, allergic contact dermatitis, scabies, extrinsic allergic alveolitis (especially chronic phase), MS, Guillain-Barre syndrome

24
Q

Type V Hypersensitivity

A

Antibodies that recognise and bind to the cell surface receptors, either stimulating them or blocking ligand bindingeg Graves’ disease, myasthenia gravis

25
Q

CEA

A

CRC maker

26
Q

Ca 125

A

Ovarian cancer marker

27
Q

Ca 19-9

A

Pancreatic cancer marker

28
Q

Ca 15-3

A

Breast cancer marker

29
Q

CLL

A

B CELL - CD 19Smudge cellshypogammaglobulinaemia leading to recurrent infectionswarm autoimmune haemolytic anaemia in 10-15% of patients

30
Q

drugs than can be haemodialysed

A

• Barbiturate• Lithium• Alcohol (inc methanol, ethylene glycol)• Salicylates• Theophyllines (charcoal haemoperfusion is preferable)

31
Q

inheritance of haemophilia A and B

A

X linked recessive

32
Q

where is the lesion?inferior hemanopia

A

paritel lobe

33
Q

where is the lesion?superior hemanopia

A

temporal lobe

34
Q

Parietal lobe lesion

A

• sensory inattention• apraxias• tactile agnosia• inferior homonymous quadrantanopia• Gerstmann’s syndrome

35
Q

Gertsman syndrome

A

lesion of dominant parietal lobealexia, acalculia, finger agnosia and right-left disorientation

36
Q

Occipital lobe lesions

A

• homonymous hemianopia (with macula sparing)• cortical blindness• visual agnosia

37
Q

Temporal lobe lesion

A

• Wernicke’s aphasia: word substituion, neologisms, speech is fluent• superior homonymous quadrantanopia• auditory agnosia• prosopagnosia (difficulty recognising faces)

38
Q

Frontal lobes lesions

A

• expressive (Broca’s) aphasia: located in the inferior frontal gyrus. Speech is non-fluent, laboured, and halting• disinhibition• perseveration• anosmia• inability to generate a list

39
Q

Cerebellum lesions

A

• midline lesions: gait and truncal ataxia• hemisphere lesions: intention tremor, past pointing, dysdiadokinesis, nystagmus

40
Q

where is - Wernicke & Korsakoff syndrome generated?

A

Medial thalamus and mammillary bodies of the hypothalamus

41
Q

where is Hemiballism generated?

A

Subthalamic nucleus of the basal ganglia

42
Q

where is Huntington chorea generated?

A

Striatum (caudate nucleus) of the basal ganglia

43
Q

where is parksinons disease generated?

A

Substantia nigra of the basal ganglia

44
Q

kluver bucy syndrome - hypersexuality, hyperorality, hyperphagia, visual agnosia

A

amygdala

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