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Pharm Block 3 Test 1 > Rab Drugs > Flashcards

Rab Drugs Flashcards

1
Q

Epinephrine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • Agonist
  • A1: High
  • A2: High
  • B1: High
  • B2: High
  • B3: Moderate
  • Selectivity: No Selectivity
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2
Q

Norepinephrine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • A1: High
  • A2: High
  • B1: High
  • B2: Low
  • B3: Moderate
  • Selectivity: No Selectivity, Low binding to B2
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3
Q

Oxymetazoline

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • A1 adrenergic Agonist
  • A1: High
  • A2: High
  • B1: High
  • B2: Low
  • B3: Moderate
  • Selectivity: No Selectivity, full a1 partial a2a
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4
Q

Phenylephrine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a1-adrenergic Agonist
  • A1: High
  • A2: Moderate
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Non Selective yet favoring a1
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5
Q

Midodrine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a1-adrenergic Agonist
  • A1: High
  • A2: Low
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Selective for a1
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6
Q

Clonidine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a2-adrenergic Agonist
  • A1: Moderate
  • A2: High
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Non Selective, yet favoring a2
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7
Q

Apraclonidine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a2-adrenergic Agonist
  • A1: Moderate
  • A2: High
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Non Selective, yet favoring a2
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8
Q

Brimonidine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a2-adrenergic Agonist
  • A1: Moderate
  • A2: High
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Non Selective, yet favoring a2
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9
Q

Methyldopa

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a2-adrenergic Agonist
  • A1: Moderate
  • A2: High
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Non selective yet favoring a2
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10
Q

Guanfacine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a2-adrenergic Agonist
  • A1: Low
  • A2: High
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Selective for a2A
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11
Q

Guanabenz

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a2-adrenergic Agonist
  • A1: Low
  • A2: High
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Selective for a2
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12
Q

Isoproterenol

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • Non selective B Agonist Favoring B1
  • A1: Low
  • A2: Low
  • B1: High
  • B2: High
  • B3: High
  • Selectivity: Non-Selective for B
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13
Q

Dopabutamine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • Non selective B Agonist Favoring B1 Agonist
  • A1: Moderate
  • A2: Very Low
  • B1: High
  • B2: Moderate
  • B3: Very Low
  • Selectivity: Selective for B1
  • Increases cardiac output with little vasoconstriction vs NEPI
  • Risk of ischemia arryhytmia much lower then isoproterenol (why iso not used)
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14
Q

Albuterol (salbutamol)

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • B2-adrenergic Agonist
  • A1: Very Low
  • A2: Very Low
  • B1: Moderate
  • B2: High
  • B3: Very Low
  • Selectivity: Short acting, Selective for B2
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15
Q

Tertbutaline

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • B2-adrenergic Agonist
  • A1: Very Low
  • A2: Very Low
  • B1: Moderate
  • B2: High
  • B3: Very Low
  • Selectivity: Short acting, Selective for B2
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16
Q

Salmeterol

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • B2-adrenergic Agonist
  • A1: Very Low
  • A2: Very Low
  • B1: Moderate
  • B2: High
  • B3: Very Low
  • Selectivity: Long Acting, Selective for B2
17
Q

Formoterol

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • B2-adrenergic Agonist
  • A1: Very Low
  • A2: Very Low
  • B1: Moderate
  • B2: High
  • B3: Low
  • Selectivity: Long acting, Selective for B2
18
Q

Indacaterol

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • B2-adrenergic Agonist
  • A1: Very Low
  • A2: Very Low
  • B1: Moderate
  • B2: High (full)
  • B3: Very Low
  • Selectivity: Ultra long acting, Selective for B2
19
Q

Olodaterol

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • B2-adrenergic Agonist
  • A1: Very Low
  • A2: Very Low
  • B1: Moderate
  • B2: High
  • B3: Very Low
  • Selectivity: Ultra long acting, Selective for B2
20
Q

Vilanterol

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • B2-adrenergic Agonist
  • A1: Very Low
  • A2: Very Low
  • B1: Moderate
  • B2: High (full)
  • B3: Very Low
  • Selectivity: Ultra long acting, Selective for B2
21
Q

Mirabrigon

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • B3-adrenergic Agonist
  • A1: Very low
  • A2: Very low
  • B1: low
  • B2: low
  • B3: High
  • Selectivity: Selective for B3
  • Bladder relaxation, b3 not expressed many other places
  • Binds some to b1 still so some pounding heart maybe
22
Q

Phenoxybenzamine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • Non selective a adrenergic Antagonist
  • A1: High
  • A2: Moderate
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Irreversible a antagonist
  • Depress baroreflex (a1)
23
Q

Phentolamine

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • Non selective a adrenergic Antagonist
  • A1: High
  • A2: High
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Non selective a antagonist
  • Depress baroreflex (a1)
  • Prevention of necrosis in case of accidental tissue injection of sympathomimetic
24
Q

Prazosin

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a1-adrenergic Antagonist
  • A1: High
  • A2: Low
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Selective for a1
  • Must be taken several times a day
  • Reduce Glucose lipid (LDL-CHOL,TG) levels
  • Dizziness and syncope w/first dose
  • nasal stuffiness, hypo, tachy
  • Depress baroreflex (a1)
25
Q

Doxasoin

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a1-adrenergic Antagonist
  • A1: High
  • A2: Low
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Selective for a1
  • Once daily
  • Reduce Glucose lipid (LDL-CHOL,TG) levels
  • Dizziness and syncope w/first dose
  • nasal stuffiness, hypo, tachy
  • Depress baroreflex (a1)
26
Q

Terazosin

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a1-adrenergic Antagonist
  • A1: High
  • A2: Low
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Selective for a1
  • Once daily
  • Reduce Glucose lipid (LDL-CHOL,TG) levels
  • Dizziness and syncope w/first dose
  • nasal stuffiness, hypo, tachy
  • Depress baroreflex (a1)
27
Q

Alfuzosin

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a1-adrenergic Antagonist
  • A1: High
  • A2: Low
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Selective for a1
  • SELECTIVE FOR PROSTATE
  • INDUCES APOPTOSIS OF PROSTATE SMOOTH MUSCLE
  • Lessened first does effect from proz tera doxa still must be taken multiple times a day
    *
28
Q

Tamsulosin

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a1-adrenergic Antagonist
  • A1: High (a1A) Moderate (a1D) Low (a1B)
  • A2: Low
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Selective for a1A
  • INEXPENSIVE AND SELECTIVE FOR PROSTATE
  • Lessened first does effect from proz tera doxa still must be taken multiple times a day
29
Q

Silodosin

  • Agonist or Antagonist
  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
A
  • a1-adrenergic Antagonist
  • A1: High (a1A) low (a1B and a1D)
  • A2: Low
  • B1: Very Low
  • B2: Very Low
  • B3: Very Low
  • Selectivity: Selective for A1a
  • SELECTIVE FOR PROSTATE
  • Reduce glucose Lipid (LDL-CHOL, TG) levels
  • Lessened first does effect from proz tera doxa still must be taken multiple times a day
30
Q

Propanolol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Very Low
  • A2: Very Low
  • B1: High
  • B2: High
  • B3: Low
  • Selectivity: Selective for B1 B2
  • Partial B1 agonist: No
  • Partial B2 agonist: No
  • Partial B3 agonist: No
  • a1 antagonist: No
  • Na Channel Blocker: Yes
  • NO Production: No
  • Ca Channel Blocker: No
  • Lipid solubility: High
  • Used for situational anxiety (B1)
  • Approved for infantile hemangiomas
  • May potentiate and maske signs of hypoglycemia in diabetics
  • Prevent effect of epi in anaphylaxis
31
Q

Pindolol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Very Low
  • A2: Very Low
  • B1: High
  • B2: High
  • B3: Moderate*
  • Selectivity: Selective for B1 B2
  • Partial B1 agonist: Moderate
  • Partial B2 agonist: No
  • Partial B3 agonist: Low
  • a1 antagonist: No
  • Na Channel Blocker: Yes
  • NO Production: Yes
  • Ca Channel Blocker: No
  • Lipid solubility: Moderate
32
Q

Timolol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Very Low
  • A2: Very Low
  • B1: High
  • B2: High
  • B3: Low
  • Selectivity: Selective for B1 B2
  • Partial B1 agonist: No
  • Partial B2 agonist: No
  • Partial B3 agonist: No
  • a1 antagonist: No
  • Na Channel Blocker: No
  • NO Production: No
  • Ca Channel Blocker: No
  • Lipid solubility: Moderate
  • Used for intraocular hypertension and glaucoma
  • Less prone to side effects then propanolol
33
Q

Metoprolol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Very Low
  • A2: Very Low
  • B1: High
  • B2: Moderate
  • B3: Very Low
  • Selectivity: Selective for B1
  • Partial B1 agonist: No
  • Partial B2 agonist: No
  • Partial B3 agonist: No
  • a1 antagonist: No
  • Na Channel Blocker: Yes low
  • NO Production: No
  • Ca Channel Blocker: No
  • Lipid solubility: moderate
  • Hemodynamically stable acute MI
  • Reduces mortality/hospitalization in patients with heart failure and those already receiving ace inhibitors, diuretics, and or digoxin
  • B1 reduce renin release
  • Crosses BBB
34
Q

Atenolol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Very Low
  • A2: Very Low
  • B1: High
  • B2: Moderate
  • B3: Very Low
  • Selectivity: Selective for B1
  • Partial B1 agonist: No
  • Partial B2 agonist: No
  • Partial B3 agonist: No
  • a1 antagonist: No
  • Na Channel Blocker: No
  • NO Production: No
  • Ca Channel Blocker: No
  • Lipid solubility: low
35
Q

Bisoprolol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Very Low
  • A2: Very Low
  • B1: High
  • B2: Moderate
  • B3: Very Low
  • Selectivity: Selective for B1
  • Partial B1 agonist: No
  • Partial B2 agonist: No
  • Partial B3 agonist: No
  • a1 antagonist: No
  • Na Channel Blocker: No
  • NO Production: No
  • Ca Channel Blocker: No
  • Lipid solubility: low
36
Q

Esmolol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Very Low
  • A2: Very Low
  • B1: High
  • B2: Moderate
  • B3: Very Low
  • Selectivity: Selective for B1
  • Partial B1 agonist: No
  • Partial B2 agonist: No
  • Partial B3 agonist: No
  • a1 antagonist: No
  • Na Channel Blocker: No
  • NO Production: No
  • Ca Channel Blocker: No
  • Lipid solubility: low
  • Afib/flutter and intraoperative and supraventricular tachycardia
  • No side effects that will last (hypotension less than 10%)
37
Q

Nebivolol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Very Low
  • A2: Very Low
  • B1: High
  • B2: low
  • B3: Moderate*
  • Selectivity: Selective for B1
  • Partial B1 agonist: No
  • Partial B2 agonist: No
  • Partial B3 agonist: Moderate
  • a1 antagonist: No
  • Na Channel Blocker: No
  • NO Production: Yes
  • Ca Channel Blocker: No
  • Lipid solubility: low
  • Alternative/adjunctive treatment of hypertension
  • ANTIOXIDANT NADPH oxidase inhibitor
  • Partial b3 agonist also activates nitric oxide synthase for vasodilation
  • NO release advantage in elderly
38
Q

Labetalol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Moderate
  • A2: Very Low
  • B1: High
  • B2: High*
  • B3: Moderate*
  • Selectivity: Weaker selectivity but favors B1, B2
  • Partial B1 agonist: No
  • Partial B2 agonist: low
  • Partial B3 agonist: low
  • a1 antagonist: Yes
  • Na Channel Blocker: Yes
  • NO Production: Yes
  • Ca Channel Blocker: No
  • Lipid solubility: low
  • Negligible amount across BBB
39
Q

Carvedilol

  • A1:
  • A2:
  • B1:
  • B2:
  • B3:
  • Selectivity:
  • Partial B1 agonist:
  • Partial B2 agonist:
  • Partial B3 agonist:
  • a1 antagonist:
  • Na Channel Blocker:
  • NO Production:
  • Ca Channel Blocker:
  • Lipid solubility:
A
  • A1: Moderate
  • A2: Very Low
  • B1: High
  • B2: High
  • B3: Moderate
  • Selectivity: Weaker selectivity but favors B1, B2
  • Partial B1 agonist: No
  • Partial B2 agonist: No
  • Partial B3 agonist: No
  • a1 antagonist: yes
  • Na Channel Blocker: yes
  • NO Production: No
  • Ca Channel Blocker: yes
  • Lipid solubility: moderate

Pharm Block 3 Test 1 (4 decks)

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