RAAS Inhibitors- Ostrom

Question 1

What are the outcomes of AT1 receptor binding of angio II?

Answer 1

vasoconstriction

release of aldosterone which causes Na+ (and fluid) retention and K+ excretion

Question 2

T or F. African Americans or low-renin hypertensives respond less favorably to ACEIs

Answer 2

T. CCBs and thiazides are more effective in this group

Question 3

Are ACEIs helpful or harmful to diabetics?

Answer 3

Helpful, they preserve renal function in diabetics

Question 4

What are some other advantages to ACEIs?

Answer 4

-little effect on lipids or sexual function

Question 5

What are some possible drug interactions of Aliskiren?

Answer 5

inhibition of p-gp

Question 6

How does the heart respond to the increase in BP caused by ACEIs, ARBs, Aliskiren, etc.?

Answer 6

left ventricular hypertrophy and vascular remodeling