RAAS Info Flashcards
where are the sensors for effective arterial blood volume?
carotid sinus
aortic arch
juxtaglomelular cells
left ventricle
3 ways to reduce effective arterial blood volume
reduce arterial blood volume
increase vascular capacitance
reduce cardiac output
what is released if there is a sense of dropping EABV?
renin from the kidneys
what cells secrete renin and where are they located?
the granular juxtglomelular cells in the afferent arteriole of the kidney
what does renin act on and convert?
angiotensinogen into angiotensin I
what enzyme changes angiotensin I into angiotensin II
angiotensin converting enzyme or an ACE
two effects that angiotensin II has
increases aldosteron secretion in kidneys
arteriolar vasoconstriction
what are the receptors for angiotensin II on vasculature?
AT1 receptor
what two roles does ACE have?
converts angiotensin I to II and metabolizes bradykinin products
what molecule in the RAAS pathways do a lot of people with primary hypertension have elevations of?
renin
two disorders associated with secondary hypertension
chronic kidney disease
primary aldosteronism
where are ACEs found? two organs
kidney and lung
