RAAS

Question 1

what is RAAS

Answer 1

renin
angiotensin
aldosterone
system

Question 2

why is RAAS necessary

Answer 2

to restore blood volume and pressure

Question 3

what is the stimulus for activation

Answer 3

drop in blood pressure

Question 5

3 ways for renin to be secreted

Answer 5

baroreceptors in the afferent arteriole
chemoreceptors in the DCT
increased sympathetic nervous system innervation

Question 6

baroreceptors in the afferent arteriole

Answer 6

juxtaglomerular cells/ granular cells
are barorecpetors
notice the drop in blood pressure
in the afferent arteriole
release renin

Question 7

chemoreceptors in the DCT

Answer 7

if the blood volume is lower the filtrate will move more slowly
more sodium can be filtered out
less sodium in the DCT
macula densa cells (chemoreceptors)
are in the DCT and in close proximity to the granular cells
renin secreted

Question 8

renin pathway

Answer 8

leaves kidney
to the bloodstream

Question 9

what is stored in the liver that is important for RAAAs

Answer 9

angiotensinogen
released into the blood stream

Question 10

action of renin

Answer 10

converts angiotensinogen to angiotensin 1

Question 11

function of angiotensin 1

Answer 11

slight vasoconstrictor
not really clinically relevant

Question 12

angiotensin 1 pathway

Answer 12

to the lungs

Question 13

what is in the lungs

Answer 13

high concentrations of angiotensin converting enzyme (ACE)

Question 14

ACE function

Answer 14

converts angiotensin 1 to angiotensin 2

Question 15

angiotensin 2 function

Answer 15

generalised vasoconstrictor
increases blood pressure
constricts the efferent arteriole
increases the GFr
increases sodium in the DCT

Question 16

angiotensin 2 pathway

Answer 16

to the cortex of the adrenal gland
stimulates aldosterone release
hypothalamus to the posterior pituitary

Question 17

aldosterone function in cortex

Answer 17

to the DCt
promotes Na+ and H2O reabsoprtion
increases blood volume and pressure