RA Meds Flashcards

1
Q

Leflunomide AE

A
warfarin interact
elevate liver enzyme
pancytopenia
agranulocytosis
thrombocytopenia
hepatotoxicity

WE PATH Le Flu by “pe”e

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2
Q

Methotrexate Monitoring

A

LFT

CBC

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3
Q

methotrexate interactions

A

Caffeine decrease effect

PPI, NSAIDs, ASA decrease renal clearance

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4
Q

leflunomide CI

A
hepatitis
immunodeficiency
Preg X
rifampin
obstructive biliary dx
Liver dx

HIP ROL

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5
Q

leflunomide Monitoring

A

WBC count
hemoglobin/hematocrit
ALT
platelet

PNEUMONIC: WHAP

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6
Q

Minocycline AE

A
photosensitive
GI
abnormal pigmentation
vertigo
Kids < 8
Pregnant
antacids
OC
anticoagulants
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7
Q

Hydroxychoroquine AE

A

rash
ab cramps
diarrhea
retinal toxicity

PNEUMONIC: RADaR

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8
Q

Sulfasalazine AE

A

N
ab discomfort
yellow/orange urine/skin

PNEUMONIC: NAY

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9
Q

methotrexate clinical response

A

1-2 mths

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10
Q

leflunomide clinical response

A

1-3 mths

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11
Q

minocycline clinical response

A

3-9 mths

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12
Q

hydroxychloroquine clinical response

A

2-6 mths

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13
Q

sulfasalazine clinical response

A

1-3 mths

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14
Q

biologic DMARDs risks

A

susceptible to infection
acute infection stop
TB

PNEUMONIC: SAT

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15
Q

what are most frequently used DMARDs for RA

A
methotrexate
leflunomide
Minocycline
Hydroxychloroquine
Sulfasalazine
Etanercept
Infliximab
Anakinra
Corticosteroids
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16
Q

Recommendation txt early RA w/

  • Low dx activity
  • mod dx activity & no poor prognosis
A

DMARD monotherapy

17
Q

Recommendation txt early RA w/

- mod dx activity & poor prognosis

A

combo DMARD therapy (2-3 drugs)

18
Q

Recommendation txt early RA w/

- high dx activity & no poor prognosis

A

DMARD monotherapy
OR
HCQ & MTX

19
Q

Recommendation txt early RA w/

-high dx activity & poor prognosis

A

Combo DMARD therapy (2-3 drugs)
OR
anti-TNF w/wout MTX