RA Meds Flashcards
Leflunomide AE
warfarin interact elevate liver enzyme pancytopenia agranulocytosis thrombocytopenia hepatotoxicity
WE PATH Le Flu by “pe”e
Methotrexate Monitoring
LFT
CBC
methotrexate interactions
Caffeine decrease effect
PPI, NSAIDs, ASA decrease renal clearance
leflunomide CI
hepatitis immunodeficiency Preg X rifampin obstructive biliary dx Liver dx
HIP ROL
leflunomide Monitoring
WBC count
hemoglobin/hematocrit
ALT
platelet
PNEUMONIC: WHAP
Minocycline AE
photosensitive GI abnormal pigmentation vertigo Kids < 8 Pregnant antacids OC anticoagulants
Hydroxychoroquine AE
rash
ab cramps
diarrhea
retinal toxicity
PNEUMONIC: RADaR
Sulfasalazine AE
N
ab discomfort
yellow/orange urine/skin
PNEUMONIC: NAY
methotrexate clinical response
1-2 mths
leflunomide clinical response
1-3 mths
minocycline clinical response
3-9 mths
hydroxychloroquine clinical response
2-6 mths
sulfasalazine clinical response
1-3 mths
biologic DMARDs risks
susceptible to infection
acute infection stop
TB
PNEUMONIC: SAT
what are most frequently used DMARDs for RA
methotrexate leflunomide Minocycline Hydroxychloroquine Sulfasalazine Etanercept Infliximab Anakinra Corticosteroids