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Oncology, Immunosupressants, And Autoimmune Dx > RA > Flashcards

RA Flashcards

1
Q

What symptom makes RA different from OA?

A

Prolonged morning stiffness

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2
Q

Have pt on DMARD within how long of RA diagnosis?

A

3 months

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3
Q

What are the non biologic DMARDs used in RA?

A 
Methotrexate 
Hydroxychloroquine 
Leflunomide
Sulfasalazine
Minocycline
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4
Q

Methotrexate is used how?

A

Alone or in combo

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5
Q

What doses of ibuprofen give anti-inflammatory affect?

A

Higher doses

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6
Q

What agents are used short term in bridge therapy in RA?

A

NSAIDS and CS

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7
Q

What type of dosing helps decrease adrenal suppression and toxic effects of steroids?

A

Alternate day therapy (ADT)

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8
Q

What are the 2 name brands for methotrexate?

A

Rheumatrex

Trexall

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9
Q

What kind of doses of methotrexate are used in RA?

A

Low weekly doses, never daily for RA

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10
Q

Methotrexate can cause what toxicity?

A

Hepatotoxicity

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11
Q

What two populations are CI in methotrexate therapy?

A

Pregnancy - category x

Alcoholism - alcohol and mtx combo increases hepatotoxicity

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12
Q

Give what with mtx to decrease side effects?

A

Folic acid

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13
Q

Give folic acid when during mtx treatment?

A

The day following mtx administration

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14
Q

Sulfasalazine should be taken with what to prevent crystalluria?

A

Food and 8 oz of water

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15
Q

What are 2 name brands of sulfasalazine?

A

Azulfidine

Sulfazine

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16
Q

Sulfasalazine can cause what deficiency?

A

Folate

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17
Q

RA manifestations are always what?

A

Polyarticular and symmetrical

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18
Q

Sulfasalazine causes what coloration of skin/urine?

A

Yellow orange

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19
Q

Sulfasalazine impairs absorption of what?

A

Folate

Supplement with 1mg of folic acid

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20
Q

What are minocycline’s 2 name brands?

A

Minocin

Solodyn

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21
Q

What instructions are needed for Minocycline administration?

A

Drink with 8 oz of water

Stay upright for 30 minutes after taking

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22
Q

Don’t give tetracycline antibiotics to what two groups of people?

A

Pregnancy

Children 8 or under

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23
Q

Tetracyclines cause what sensitivity?

A

Photosenitivity

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24
Q

What is leflunomide’s name brand?

A

Arava

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25
Q

Who should absolutely not get leflunomide?

A

Pregnant women

Category X

26
Q

Must wait how long after discontinuing leflunomide to get pregnant?

A

2 years after

27
Q

Leflunomide can cause what toxicity?

A

Hepatotoxicity

28
Q

What DMARDs can you take with methotrexate?

A

Leflunomide

Tofacitinib

29
Q

What if Tofacitinib name brand?

A

Xeljanz

30
Q

Don’t use Xeljanz with what other RA agents?

A

Biologic DMARDs

31
Q

Don’t take methotrexate with what because increase risk of hepatotoxicity?

A

Alcohol

32
Q

Methotrexate decreases the effectiveness of what diuretics?

A

Loops

33
Q

Loop diuretics to what to methotrexate?

A

Increase methotrexate concentrations

34
Q

Methotrexate when used concomitantly with what med cause an increase in both med concentrations?

A

Cyclosporine

35
Q

Methotrexate is what pregnancy category?

A

X

36
Q

What main class of biologic DMARDs are used in RA?

A

TNF inhibitors

37
Q

What is etanercept name brand?

A

Enbrel

38
Q

What is Humira generic?

A

Adalimumab

39
Q

What is Remicades generic?

A

Infliximab

40
Q

What is certolizumab name brand?

A

Cimzia

41
Q

What is Simponi generic?

A

Golimumab

42
Q

What TNF inhibitors are used only in combo with methotrexate for RA?

A

Remicade

Simponi

43
Q

What should be tested for before starting biologics?

A

TB test

44
Q

All TNF inhibitors must be stored how?

A

In refrigerator

45
Q

Allow each TNF inhibitors to do what before administration?

A

Come to room temp over 15-30 minutes

46
Q

Don’t use biologics how?

A

More than one concurrently

47
Q

What 4 bad things can happen with TNF inhibitor therapy?

A

HBV reactivation
Heart failure
Hepatotoxicity
Lupus like syndrome

48
Q

What is rituximabs name brand?

A

Rituxan

49
Q

How does rituximab work?

A

Deleted CD20 B cells

50
Q

Is Rituxan given with or without methotrexate in RA?

A

With

51
Q

Screen for what two things before Rituxan initiation?

A

TB

HBV

52
Q

Anakinra has what mechanism of action?

A

IL-1 receptor antagonist

53
Q

What is Anakinra’s name brand?

A

Kineret

54
Q

What MOA does abatacept have?

A

Inhibits T cell activation by binding to CD80 and CD86

55
Q

What is abatacept name brand?

A

Orencia

56
Q

Caution abatacept use with what co morbidity?

A

COPD

may worsen symptoms

57
Q

MOA of tocilizumab?

A

IL-6 receptor antagonist

58
Q

What is tocilizumab’s name brand?

A

Actemra

59
Q

Where should biologics be administered?

A

Upper middle thigh

Abdomen

60
Q

What vaccine can patients in biologics still get?

A

Influenza

61
Q

Get Simponi to room temperature how?

A

Letting product sit at room temp for 30 minutes

Oncology, Immunosupressants, And Autoimmune Dx (1 decks)

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