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Question 1

Ethology of EN?

Answer 1

Idiopathic (most common)
Infection (e.g. streptococcal pharyngitis, histoplasmosis, coccidioidomycosis, TB, leprosy)
Autoimmune diseases (e.g. sarcoidosis, Crohn disease, ulcerative colitis, Behcet syndrome)
Drugs (oral contraceptives, sulfonamides, iodide)
Pregnancy
Malignancy

Question 2

Diagnosis?

Answer 2

clinical

Question 3

What to do?

Answer 3

Imaging and laboratory tests determine the underlying condition
CBC, ESR
Antistreptolysin-O titer; throat or blood culture
Chest x-ray: hilar lymphadenopathy (e.g., in sarcoidosis, tuberculosis)
VDRL
Inflammatory bowel disease workup
Skin biopsy if diagnosis is uncertain

Question 4

Tx

Answer 4

Symptomatic treatment
Bed rest
Leg elevation
Heat or cool compresses
NSAIDS (e.g., ibuprofen)
Potassium iodide 
Treat underlying disease