Quiz 6 Flashcards
What is produced from filtration in the kidney?
Filtrate = filtered plasma without proteins or RBC
What is filtration?
Passive leakage of plasma
What is the filtration fraction?
% of plasma passing through glomerulus that is filtered = 20%
What is the glomerular filtration rate (GRF)?
Volume filtered/ time
What are the 3 barriers that substances leaving the plasma must pass?
- Fenestrated capillary endothelium
- Basement membrane
- Podocytes (filtration slits) of epithelium of Bowman’s capsule
What is the filtration coefficient increased by?
-SA of glomerular capillaries
-Permeability of filtration slits
What does the GFR in the renal corpuscle depend on?
-Glomerular hydrostatic pressure (Ph) = Blood pressure
-Colloid osmotic pressure (pi)
-Capsule fluid pressure
What is the primary driving force for most reabsorption?
Na+
What happens during reabsorption?
Filtrate –> interstitial fluid –> blood in peritubular capillaries
How is Na+ reabsorbed?
Diffuses passively from filtrate into tubule cell via carriers then actively transported into interstitial fluid
Why is Na+ the primary driving force for most reabsorption?
-Anions follow Na+
-Water follows solutes by osmosis
What is the Na+-linked transport used for?
Used for reabsorption of many valuable substances such as glucose that is reabsorbed by SGLT transporter against its concentration gradient
What is the Na+-linked transport used for?
Used for reabsorption of many valuable substances such as glucose that is reabsorbed by SGLT transporter against its concentration gradient
What is the transport maximum (Tm)?
Transport rate at saturation
What is the renal threshold?
Plasma concentration at which saturation occurs
