Quiz 6 Flashcards
Atenelol
Tenormin
Lovastatin
Altoprev
Lisinopril
Prinivil, Zestril
Losartan
Cozaar
Amlodipine
Norvasc
Hydrochlorothiazide
various
Candesartan
Atacand
Indications: Angina pectoris, HTN, AMI
Atenolol
Indications: Coronary arteriosclerosis; hypercholesteremia, primary and fixed; familial hypercholesteremia, heterozyogous
Lovastatin
Indications: st-segment elevation, MI; HFrEF; HTN
Lisinopril
Indications: HTN, Reduced risk of cerebrovascular accident, diabetic nephropathy
Losartan
Indications: HTN; stable and variant angina
Amlodipine
Indications: edema, HTN
Hydrochlorothiazide
Indications: HF, HTN
Candesartan
Interactions: NSAIDs, amiodarone, dronedarone, antidiabetics, CCBs, quinidine, clonidine
Atenolol
Interactions: CYP3A4/5 inhibitors and inducers, fibrates, niacin
Lovastatin
Interactions: ARBs, K-sparing diuretics, azathioprine, cyclosporine diuretics, NSAIDs, K-supplements, salt subs, sacubitril
Lisinopril
Interactions: ACEIs, Diuretics, Aliskiren, CYP2CP and CYP3A4/5 inhibitors and inducers, K supplements, salt subs, NSAIDs
Losartan
Interactions: CYP3A4/5 inhibitors and inducers, NSAIDs
Amlodipine
Interactions: ace/arbs, antiarrhythmic agents, digoxin, antidiabetic meds, calcium supplements, carbamazepine, NSAIDs, Topiramate, lithium, dofetilide
Hydrochlorothiazide
Interactions: Aldosterone antagonists, ACE, K supplements, NSAIDs, Diuretics
Candesartan
Common AR: hypotension
Candesartan
Common AR: hypotension, dizziness, headache
HCTZ
Common AR: Peripheral Edema, PE
Amlodipine
Common AR: headache
Losartan
Common AR: n/a
Lisinopril and Lovastatin
Common AR: Bradyarrhythmia, cold extremities, dizziness, fatigue, hypotension, depression
Atenolol
RbS: HF, PE
Atenolol
RbS: Rhabdomyolysis, hepatotoxicity, inc. risk of diabetes
Lovastatin
RbS: angioedema, liver failure, birth defects
Lisinopril
RbS: angioedema, birth defects, hepatotoxicity, rhabdomyolysis
Losartan
RbS: hepatotoxicity, thrombocytopenia, AMI, angina
Amlodipine
RbS: Cardiac arrhythmias, hepatitis, pancreatitis, SJ syndrome
HCTZ
RbS: angioedema, birth defects, hepatotoxicity, rhabdomyolysis
Candesartan
Efficacy: Dec. BP
All but statin
Efficacy: reduction in chest pain, dec. number of weekly angina attacks, reduction in use of prophylactic nitroglycerin to relieve chest pain, improvement in s/s of HF
Atenelol
Toxicity: s/s of HF, dec. HR. monitor serum electrolytes and renal function at baseline and periodically
Atenelol
Counseling: Tk on empty stomach. Avoid abrupt discontinuation; exacerbations of angina may occur. Report s/s of bradycardia, hypotension, HF, or exacerbation of angina w/ initial dosing and dose changes. May cause dizziness or drowsiness. Diabetic pt. to carefully follow blood sugar lvls as beta-blockers may mask symptoms of hypoglycemia. Drug may cause sexual side effects, fatigue, and depression.
Atenelol
Efficacy: Reduction in total cholesterol, LDL- cholesterol, and triglyceride levels; inc. in HDL-cholesterol levels. Assess at baseline and periodically during treatment
Lovastatin
Toxicity: s/s of rhabdomyolysis or hepatotoxicity. LFTS, blood glucose, and HbA1C should be performed at baseline, 6-12 wk after initiation of therapy, and periodically thereafter; SCr kinase should be measured in pt. experiencing muscle pain and in those receiving other drugs associated w/ myopathy
Lovastatin
Counseling: IR tablets should be taken w/ evening meal. ER tablets should be taken at bedtime and swallowed whole (don’t chew, crush, or cut). Avoid alcohol and grapefruit. Report s/s of rhabdomyolysis, jaundice, or renal failure. Lots of interactions. Consult PCP prior to starting any new prescriptions or OTC meds. Lovastatin does not take place of lifestyle changes to lower cholesterol levels.
Lovastatin
Toxicity: s/s of angioedema, severe persistent cough, hypotension, monitor baseline and periodic electrolytes, SCr, BUN, and urine protein
Lisinopril
Counseling: Avoid pregnancy. Use K supplements or salt substitutes only under medical supervision. May cause dizziness in women if dehydrated
Lisinopril
Toxicity: s/s of peripheral edema. Baseline and periodic electrolyte panel, renal function tests, and urine protein are recommended
Losartan
Counseling: avoid pregnancy. Avoid sudden discontinuation; rebound htn can occur. Use K supplement and salt subs under medical supervision. May cause dizziness and may worsen w/ dehydration. Seek medical attention if angioedema, excessive fluid loss, hyperkalemia, reduction in urination, or jaundice occurs
Losartan
Efficacy: reduction in chest pain, dec. number of weekly angina attacks, reduction in use of prophylactic nitroglycerin to relieve chest pain, improvement in s/s of HF
amlodipine
Toxicity: s/s of peripheral edema, inc. HR, LFTs
Amlodipine
Counseling: Instruct pt. to report s/s of hypotension or exacerbation of angina w/ initial dosing or dose changes. Avoid alcohol. Report s/s of peripheral edema, fatigue, hypotension, or hepatic dysfunction. May cause dizziness. Avoid activities that could be dangerous if dizziness occurs at initiation of therapy. Dizziness may be worse if too much water is lost from the body due to excessive sweating, diarrhea, or vomiting.
Amlodipine
Efficacy: reduction in edema
HCTZ
Toxicity: Dec. serum and urine electrolytes (particularly serum sodium), dec. renal fuction, inc. serum uric acid or blood glucose. Seek medical attention if skin rash, jaundice, dec. urine output, or symptoms of gout. Dizziness, lighthededness may occur. Monitor Na, K, BUN, creatinine, skin to assess photosensitivity, skin cancer.
HCTZ
Counseling: May be taken w/ or w/o food. Tk early to avoid nocturia, even if taken more than once/d. May cause dizziness. Report s/s of hypotension. Eat high-K foods during therapy. Avoid alcohol and NSAIDs
HCTZ
Efficacy: resolution of HF; may require 3-6 wk to obtain therapeutic response
Candesartan
Toxicity: Report s/s of hypotension, tachycardia. Baseline and periodic sodium, potassium, total bicarb, BUN, SCr, and urinalysis prior to initiating therapy.
Candesartan
Counseling: Avoid pregnancy and notify physician immediately if become pregnant. Use K supplements or salt subs only under medical supervision. May cause dizziness that may worsen if dehydrated. Seek care if angioedema, excessive fluid loss, hyperkalemia, reduction in urination, or jaundice occurs
Candesartan
