Quiz 5 NSAIDS, acne, antivirals

Question 1

Acute inflammation

Answer 1

fast onset
neutrophils
mild and self limited
prominent systemic signs

Question 2

Chronic Inflammation

Answer 2

can lead to cancer, pumonary diseases, CV, diabetes, alzheimers, perio, neuro, arthritis.

Question 3

Celecoxib

Answer 3

Cox 2 selective

CV is a BIG DEAL SE.

Question 4

Glucocorticoids

Answer 4

Inhibit phospholipases

• Rapidly acting
• Dramatic effect on inflammation and slowing bone erosions in rheumatoid arthritis
• Side effect: loss of muscle mass, osteoporosis, diabetogenesis, peptic ulcers, round face, buffalo hump

Question 5

dexamethasone

Answer 5

long-acting steroid

Question 6

Cortisone, prednisone

Answer 6

short to medium acting. steroid

Question 7

GCs AEs

Answer 7

• Loss of muscle mass, muscle weakness, thinning of skin, impaired wound healing, insomnia and osteoporosis are all dose-dependent
• Diabetogenesis
• Peptic ulcers

Question 8

Acne

Answer 8

inflammation/bacterial infection of plugged sebaceous glands: white heads, cysts, abscesses

Question 9

Topical keratolytics

Answer 9

removes keratin layer and opens sebaceous glands

• Salicylic acid
• Benzoyl peroxide

Question 10

Antibiotics

Answer 10

Erythromycin, tetracycline, clindamycin and DAPSONE-eliminate the bacteria that cause the infection and inflammation associated with acne.
Can use either topical or systemic.
Drugs concentrate in skin.

Question 11

Retinoids

Answer 11

vitamin A-derivatives;

• Side effects: dry skin, sores, major birth defects with isotretinoin

Question 12

Isotretinoin

Answer 12

Accutane
Systemic acne treatment
BIRTH DEFECTS!!!!!

Question 13

tretinoin

Answer 13

retin A: topical treatment for acne

Question 14

Clindamycin

Answer 14

Antiribosomal against G+ and anaerobes

SE: Ulcerative Colitis

Question 15

Metronidazol

Answer 15

inhibits Demadex brevis

Question 16

Dapsone

Answer 16

sulfone gel for acne treatment

Question 17

succinyl choline

Answer 17

block ganglionic nicotinic receptors by desensitizing (overstimulating?)
depolarizing muscle relaxant TWITCH!!!!!!
30 sec onset
short lasting

Question 18

D-tubocurarine

Answer 18

blocks ganglionic nicotinic receptor

Question 19

Malignant hyperthermia

Answer 19

abnormal release of Ca++ from muscle storage, caused by depolarizing relaxant drugs

Question 20

Diazepam

Answer 20

GABAa receptor antagonist

Question 21

Baclofen

Answer 21

GABAb receptor agonist

Question 22

Carisoprodol (Soma

Answer 22

muscle relaxant/sedative; may have some dependence problems

Question 23

Acycolvir

Answer 23

most effective for HSV. less potent on VZV

Question 24

Famciclovir

Answer 24

effective against VZV, longer acting than cyclovir.

Question 25

Foscarnet

Answer 25

does not require activation by thiamidine kinase. So can be used in resistant strains.

Question 26

DMARDS

Answer 26

Methotrexate, Sulfasalazine

Decrease inflm. and slow bone damage in arthritis

potentially more toxic
stomatitis
immunosuppression

Question 27

ach-esterase inhibitor

Answer 27

overwhelms blockade with Ach

irreversible

Question 28

Dantrolene

Answer 28

Alters Ca++ trafficking