Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

My System Pharmacology 1 Material > Quiz 3 Material > Flashcards

Quiz 3 Material Flashcards

1
Q

Azithromycin (Zpak, Zithromax)

A

Macrolides/Ketolides

MOA: Binds to 50s ribosomal subunit and block peptidyltransferase center to prevent AA elongation (also inhibit 50s subunit formation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Demeclocycline

A

Tetracyclines

MOA: Reversibly bind to the 30s ribosomal subunit preventing binding of tRNA = prevent protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Neomycin

A

Aminoglycosides

MOA: Bind to specific 30s ribosomal proteins and interfere with the initiation of protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Tigecycline

A

Tetracyclines

MOA: Reversibly bind to the 30s ribosomal subunit preventing binding of tRNA = prevent protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Streptomycin

A

Aminoglycosides

MOA: Bind to specific 30s ribosomal proteins and interfere with the initiation of protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Telithromycin

A

Macrolides/Ketolides

MOA: Binds to 50s ribosomal subunit and block peptidyltransferase center to prevent AA elongation (also inhibit 50s subunit formation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Minocycline

A

Tetracyclines

MOA: Reversibly bind to the 30s ribosomal subunit preventing binding of tRNA = prevent protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Gentamicin

A

Aminoglycosides

MOA: Bind to specific 30s ribosomal proteins and interfere with the initiation of protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Amikacin

A

Aminoglycosides

MOA: Bind to specific 30s ribosomal proteins and interfere with the initiation of protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Chloramphenicol

A

Other Protein Synthesis Inhibitors

MOA: Binds to the 50s subunit and inhibits peptide bond formation, Also has a high affinity to mammalian mitochondrial ribosomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Clindamycin

A

Other Protein Synthesis Inhibitors

MOA: Same as erythromycin: Bind to the 50s ribosomal subunit and block the peptidyltransferase center to prevent AA chain elongation, Can also inhibit formation of the 50s subunit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Linezolid

A

Other Protein Synthesis Inhibitors

MOA: Inhibits formation of ribosomal complex, which binds to the 50s subunit near interface with the 30s subunit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Doxycycline

A

Tetracyclines

MOA: Reversibly bind to the 30s ribosomal subunit preventing binding of tRNA = prevent protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Fidaxomicin

A

Macrolides/Ketolides

MOA: Binds to 50s ribosomal subunit and block peptidyltransferase center to prevent AA elongation (also inhibit 50s subunit formation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cotrimoxazole (Trimethoprim + Sulfamethoxazole)

A

Antifolate Drugs (Sulfa-Drugs)

MOA: Combination of trimethoprim and sulfamethoxazole – greater activity and broader spectrum than either drug used alone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Ciprofloxacin (Cipro)

A

2nd Generation Fluoroquinolones

MOA: Dual mechanism: Inhibit replication of DNA by interfering with DNA gyrase and topoisomerase IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Ofloxacin

A

2nd Generation Fluoroquinolones

MOA: Dual mechanism: Inhibit replication of DNA by interfering with DNA gyrase and topoisomerase IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Moxifloxacin

A

4th Generation Fluoroquinolones

MOA: Dual mechanism: Inhibit replication of DNA by interfering with DNA gyrase and topoisomerase IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Clarithromycin

A

Macrolides/Ketolides

MOA: Binds to 50s ribosomal subunit and block peptidyltransferase center to prevent AA elongation (also inhibit 50s subunit formation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Posaconazole

A

Azoles

MOA: Inhibits the P450 enzyme responsible for converting lanosterol to ergosterol (disrupts fungal membrane structure and function), also inhibits human and gonadal and adrenal steriod synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Levofloxacin (Levaquin)

A

3rd Generation Fluoroquinolones

MOA: Dual mechanism: Inhibit replication of DNA by interfering with DNA gyrase and topoisomerase IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Erythromycin

A

Macrolides/Ketolides

MOA: Binds to 50s ribosomal subunit and block peptidyltransferase center to prevent AA elongation (also inhibit 50s subunit formation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Norfloxacin

A

2nd Generation Fluoroquinolones

MOA: Dual mechanism: Inhibit replication of DNA by interfering with DNA gyrase and topoisomerase IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Gemifloxacin

A

4th Generation Fluoroquinolones

MOA: Dual mechanism: Inhibit replication of DNA by interfering with DNA gyrase and topoisomerase IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Tobramycin

A

Aminoglycosides

MOA: Bind to specific 30s ribosomal proteins and interfere with the initiation of protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Sulfacetamide

A

Antifolate Drugs (Sulfa-Drugs)

MOA: Compete with dihydropteroate synthetase and inhibit folate production in bacteria (thus inhibit division and growth), Structural analogues of PABA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Nitrofurantoin

A

Urinary Tract Antiseptics

MOA: Bacteria that are sensitive reduce the drug to a toxic intermediate (damages bacterial DNA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Fluconazole

A

Azoles

MOA: Inhibits the P450 enzyme responsible for converting lanosterol to ergosterol (disrupts fungal membrane structure and function), also inhibits human and gonadal and adrenal steriod synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Sulfamethoxazole

A

Antifolate Drugs (Sulfa-Drugs)

MOA: Compete with dihydropteroate synthetase and inhibit folate production in bacteria (thus inhibit division and growth), Structural analogues of PABA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Micafungin

A

Echinocandins

MOA: interfere with the synthesis of B-glucan, which disrupts cell wall and causes lysis and cell death

33
Q

Trimethoprim

A

Antifolate Drugs (Sulfa-Drugs)

MOA: Inhibits dihydrogolate reductase – prevents conversion of dihydrofolic acid to tetrahydrofolic acid (thus interfere with folate production in bacteria), higher affinity to bacterial enzyme than mammalian

33
Q

Methenamine

A

Urinary Tract Antiseptics

MOA: Decomposed at acidic pH of 5.5 or less, Produces formaldehyde which is toxic to bacteria

34
Q

Amphotericin B

A

Polyene Antibiotics

MOA: Binds to ergosterol in the plasma membrane and forms a pore

35
Q

Tetracycline

A

Tetracyclines

MOA: Reversibly bind to the 30s ribosomal subunit preventing binding of tRNA = prevent protein synthesis

36
Q

Capreomycin

A

Second-Line Antimycobacterial Drugs

MOA: Inhibits protein synthesis

37
Q

Ketoconazole

A

Azoles

MOA: Inhibits the P450 enzyme responsible for converting lanosterol to ergosterol (disrupts fungal membrane structure and function), also inhibits human and gonadal and adrenal steriod synthesis

38
Q

Voriconazole

A

Azoles

MOA: Inhibits the P450 enzyme responsible for converting lanosterol to ergosterol (disrupts fungal membrane structure and function), also inhibits human and gonadal and adrenal steriod synthesis

39
Q

Anidulafungin

A

Echinocandins

MOA: interfere with the synthesis of B-glucan, which disrupts cell wall and causes lysis and cell death

39
Q

Caspofungin

A

Echinocandins

MOA: interfere with the synthesis of B-glucan, which disrupts cell wall and causes lysis and cell death

40
Q

Nystatin

A

Polyene Antibiotics

MOA: Binds to ergosterol in the plasma membrane and forms a pore

41
Q

Flucytosine

A

Other Antifungal Drugs

MOA: Enters fungal cell and disrupts DNA/protein synthesis (similar to anti-metabolites)

42
Q

Griseofulvin

A

Other Antifungal Drugs

MOA: Inhibits fungal mitosis, deposited in newly forming skin protecting it from new infection

43
Q

Terbinafin

A

Other Antifungal Drugs

MOA: Inhibits squalene epoxidase - Causes: block biosynthesis of ergosterol AND squalene builds up and becomes toxic

44
Q

Ethambutol

A

First-Line Antimycobacterial Drugs

MOA: interfere with cell wall synthesis

45
Q

Sulfadiazine

A

Antifolate Drugs (Sulfa-Drugs)

MOA: Compete with dihydropteroate synthetase and inhibit folate production in bacteria (thus inhibit division and growth), Structural analogues of PABA

46
Q

Isoniazid

A

First-Line Antimycobacterial Drugs

MOA: Prodrug (activated by mycobacterial enzyme), active molecule targets enzymes responsible for synthesis of mycolic acid and blocks its production (mycolic acid = essential for cell wall integrity)

47
Q

Pyrazinamide

A

First-Line Antimycobacterial Drugs

MOA: Lowers intracellular pH and inhibits growth

48
Q

Rifampin

A

First-Line Antimycobacterial Drugs

MOA: Interacts with bacterial RNA polymerase (block transcription)

49
Q

Rifabutin

A

First-Line Antimycobacterial Drugs

MOA: Interacts with bacterial RNA polymerase (block transcription)

50
Q

Oseltamivir (Tamiflu)

A

Antiviral Drugs for Respiratory Virus Infections (Influenza)

MOA: Neuraminidase Inhibitors = selectively inhibits the enzyme neuraminidase (which is essential to live cycle of this virus) and prevent release of new virions (works against Type A and B)

51
Q

Rifapentine

A

First-Line Antimycobacterial Drugs

MOA: Interacts with bacterial RNA polymerase (block transcription)

52
Q

Ethionamide

A

Second-Line Antimycobacterial Drugs

MOA: Structurally similar to Isoniazid - Prodrug (activated by mycobacterial enzyme), active molecule targets enzymes responsible for synthesis of mycolic acid and blocks its production (mycolic acid = essential for cell wall integrity)

53
Q

Cycloserine

A

Second-Line Antimycobacterial Drugs

MOA: Prevents cell wall synthesis

54
Q

Telaprevir

A

Antiviral Drugs for Hepatitis

MOA: bind to active site of HCV protease

55
Q

Streptomycin

A

Second-Line Antimycobacterial Drugs

MOA: Bind to specific 30s ribosomal proteins and interfere with the initiation of protein synthesis

57
Q

Macrolides

A

Second-Line Antimycobacterial Drugs

MOA: Binds to 50s ribosomal subunit and block peptidyltransferase center to prevent AA elongation (also inhibit 50s subunit formation)

58
Q

Dapsone

A

Drugs Used in Leprosy

MOA: Similar to sulfonamides, inhibits folate synthesis

59
Q

Amantadine

A

Antiviral Drugs for Respiratory Virus Infections (Influenza)

MOA: Inhibitors of Viral Uncoating = block viral membrane matrix protein MA (which functions as a channel for H+ ions, required for fusion of viral membrane with host cell membrane)

60
Q

Fluoroquinolones

A

Second-Line Antimycobacterial Drugs

MOA: Dual mechanism: Inhibit replication of DNA by interfering with DNA gyrase and topoisomerase IV

61
Q

Rimantadine

A

Antiviral Drugs for Respiratory Virus Infections (Influenza)

MOA: Inhibitors of Viral Uncoating = block viral membrane matrix protein MA (which functions as a channel for H+ ions, required for fusion of viral membrane with host cell membrane)

62
Q

Zanamivir

A

Antiviral Drugs for Respiratory Virus Infections (Influenza)

MOA: Neuraminidase Inhibitors = selectively inhibits the enzyme neuraminidase (which is essential to live cycle of this virus) and prevent release of new virions (works against Type A and B)

63
Q

Boceprevir

A

Antiviral Drugs for Hepatitis

MOA: bind to active site of HCV protease

64
Q

Interferon

A

Antiviral Drugs for Hepatitis

MOA: Induce host cell enzymes to inhibit viral RNA translation

65
Q

Lamivudine

A

Antiviral Drugs for Hepatitis

MOA: Inhibits hepatitis B DNA polymerase and HIV reverse transcriptase

66
Q

Tenofovir

A

Antiviral Drugs for Hepatitis

MOA: Inhibits viral reverse transcriptase

67
Q

Acyclovir

A

Antiviral Drugs for Herpesvirus Infections

MOA: Converted to active form by viral enzyme (thymidine kinase), competes as a substrate for viral DNA polymerase and is incorporated into the viral DNA

68
Q

Famciclovir

A

Antiviral Drugs for Herpesvirus Infections

MOA: Converted to active form by viral enzyme (thymidine kinase), competes as a substrate for viral DNA polymerase and is incorporated into the viral DNA

69
Q

Valacyclovir

A

Antiviral Drugs for Herpesvirus Infections

MOA: Converted to active form by viral enzyme (thymidine kinase), competes as a substrate for viral DNA polymerase and is incorporated into the viral DNA

70
Q

Ganciclovir

A

Antiviral Drugs for Cytomegalovirus Infections

MOA: must be activated by viral enzyme, inhibits viral DNA polymerase and can be Incorporated into viral DNA

71
Q

Ribavirin

A

Antiviral Drugs for Hepatitis

MOA: activated by kinases that phosphorylate the drug, active metabolites inhibit purine metabolism (block synthesis of viral DNA and RNA)

72
Q

Itraconazole

A

Azoles

MOA: Inhibits the P450 enzyme responsible for converting lanosterol to ergosterol (disrupts fungal membrane structure and function), also inhibits human and gonadal and adrenal steriod synthesis

72
Q

Clofazimine

A

Drugs Used in Leprosy

MOA: Binds to DNA and prevents it from serving as a template for replication

73
Q

Cidofovir

A

Antiviral Drugs for Cytomegalovirus Infections

MOA: inhibits viral DNA synthesis, does NOT depend on vial enzymes

74
Q

Trifluridine

A

Antiviral Drugs for Herpesvirus Infections

MOA: inhibits the incorporation of thymidine triphosphate into viral DNA, can incorporate into viral DNA (and cellular DNA)

My System Pharmacology 1 Material (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions