Quiz 3 Flashcards
Dx: Gonococall pharyngitis
DNA probe
Gonococcal pharyngitis is an important source of ___.
gonococcemia
What is the MC deep neck infection in children and young adults?
peritonsillar abscess
Which glands, when infected, become the source of infection in Peritonsillar abscess?
Weber’s glands
Risk factors: Peritonsillar abscess
Acute tonsillitis, pharyngitis, periodontal disease, smoking
There is a strong association between Peritonsillar abscess and which medication?
NSAIDs
SSx: Peritonsillar abscess
Appears ill, trismus, drooling, unable to swallow, hot potato voice, unilateral tonsil hypertrophy w/ contralateral displaced uvula
PE: Peritonsillar abscess
CxLA on ipsilateral side, palpate for fluctuance (abscess)
Complications: Peritonsillar abscess
Airway obstruction, meningitis, septicemia, aspiration pneumonia, GABHS sequelae, carotid artery rupture, Lemierre Syndrome
DX: Peritonsillar abscess
Needle aspiration (gold standard), U/S, CT
What is Lemierre Syndrome?
Internal jugular vein thrombophlebitis and sepsis
Complication of Peritonsillar abscess
Tx: Peritonsillar abscess
Refer for I and D
Etiology: Peritonsillar abscess
Polymicrobial
GABHS, Strep pyogenes, Staph A, respiratory anaerobes
Etiology: Diphtheria
Corynebacterium diphtheriae
SSx: Diphtheria
Blue/white membrane adhered to posterior pharynx
SSx: Retropharyngeal abscess
Dyspnea, stridor, hot potato voice, stiff neck, pain referred to post. neck
Etiology: Retropharyngeal abscess
2’ to dental infx, foreign body insult, trauma
PE: Retropharyngeal abscess
High fever, ant. bulging in post. pharynx
Location: Ludwig’s angina
Submental space infx
SSx: Ludwig’s angina
Severe trismus, drooling, airway compromise
PE: Ludwig’s angina
Collar of brawny edema (neck), elevation of tongue, possible airway obstruction
Etiology: Necrotizing fasciitis
Complication of Strep
Population: Epiglottitis
2-5 yo (MC)
Etiology: Epiglottitis
HiB (MC)
SSx: Epiglottitis
Sore throat, high fever, weak voice, hot potato voice, drooling, tripod position, stridor
PE: Epiglottitis
Trismus, swollen uvula
What part of the PE for epiglottitis is contraindicated in children?
Visualization of the supraglottic area
Dx: Epiglottitis
Lateral X-ray (thumbprint sign)
Condition: sore throat < AM, > hot drinks
Post-nasal drip
Which vitamin can improve the integrity of esophageal epithelium?
Vitamin A
DDx: Chronic sore throat
Malignancy, Chronic cough, Vocal abuse, Sick House Syndrome, Smoking, Solvent use, Post-nasal drip, Reflux pharyngitis, Post-nasal drip, Infectious (esp. Mono)
Kawasaki Disease
Acute, self-limited vasculitis that occurs in children of all ages
SSx: Kawasaki Disease
Conjunctivits (non-exudative) Rash (polymorphous non-vesicular) Edema (or erythema of hands/feet) Adenopathy (cervical) Mucosal involvement (erythema, fissures, crusting)
Low-pitch hoarseness is suggestive of ___
hypothyroidism
Red flags: hoarseness d/t malignancy
Hx of smoking, heavy EtOH use, weight loss, stridor
DDx (Neuro): Hoarseness
Parkinson’s, MS, myasthenia gravis
Most vocal cord paralysis is (unilateral/bilateral) and is caused by damage to the ___.
unilateral
recurrent laryngeal nerve
Bilateral vocal chord paralysis is MC d/t ___.
complication from thyroid surgery
Etiology: Hoarseness d/t chronic vocal laryngitis
Smoking, vocal abuse, laryngopharyngeal reflux, allergies, inhaled glucocorticoids
When hoarseness lasts longer than 2 weeks w/o a clear benign cause, ___. An exception to this rule is ___.
do a direct or indirect laryngoscopy
patients w/ asthma on inhaled corticosteroids
Etiology: Globus
GERD (MC), abnormal UES, psychological and psychiatric d/o, stress, inflammatory dz, thyroid dz
Red flags: Globus
Dysphagia, pain, wt loss, hoarseness, neck mass
Conditions associated with globus
Cervical osteophyte, TMJ d/o, salivary hypofunction
Tx: Globus
Mg, homeopathy, acupuncture
Etiology (endocrine): Hoarseness
Hypothyroid, acromegaly
SSx: OSA
Overweight, snore loudly, chronic daytime sleepiness
Tx: Mild OSA
Abstaining from alcohol and sedatives, losing weight, avoiding supine position during sleep
Tx: Severe OSA
CPAP, palatal surgery, jaw surgery, tracheotomy
How is severity of OSA measured?
Apnea-hypopnea index (number of sleep events per hour)
Long-term mortality increases in pts treated for OSA with a apnea-hypopnea index > ___.
20 events per hour
Morbidities associated with OSA
Metabolic syndrome, IHD, HTN, CHF, arrhythmias, cerebral vascular dz, pulmonary vascular dz, memory deficit, inc. risk for accidents/CV events
Bulbar conjunctiva
corner of eye
Palpebral conjunctiva
under surface of lids
Innervation: cornea
CN V
Mydriasis
dilation of pupil
Myosis
constriction of pupil
What produces aqueous humour?
ciliary body
What provides the major blood supply to the eye?
Choroid
Differentiate rods vs. cones
Both are light receptors
Rods are sensitive to light, insensitive to color, important for night vision and dim light
Cones are sensitive to color
What is the name of the yellow spot in the center of the retina, 2 cm lateral to optic disk?
Macula lutea
Where is the highest concentration of cones?
Fovea centralis
DDx: Acute vision loss (media problems)
Keratitis, hyphema, cataract, vitreous hemorrhage, uveitis
DDx: Acute vision loss (retinal problems)
Vascular occlusion, retinal detachment, acute maculopathy
DDx: Acute vision loss (neural visual pathway problems)
Optic nerve, optic chiasm, retrociasmal (occipital lobe)
Bilateral vision loss suggests ____.
occipital involvement
DDx: sharp superficial eye pain
Keratitis
DDx: deep brow pain w/ N/V
acute glaucoma, uveitis (no N/V)
DDx: eye pain < movement
optic neuritis
DDx: vision loss w/ eye pain
Keratitis, acute gluacoma, uveitis, optic neuritis
DDx: vision loss w/ red eye
Keratitis, acute glaucoma, uveitis
Nearsighted eyes increase risk for ___.
retinal tears -> retinal detachment
Wearing contact lenses increases risk for ___.
bacterial keratitis
What is Fluorescein dye used for?
corneal ulcers and abrasions
DDx: Unilateral, painless vision loss
Lens dislocation, vitreous hemorrhage, acute maculopathy, retinal detachment, retinal vein/artery occlusion, ischemic optic neuropathy
DDx: Unilateral, painful vision loss
Corneal abrasion, keratitis, acute glaucoma, hyphema, iritis/uveitis
DDx: Bilateral, painless vision loss
Pseudo-tumor cerebri, metabolic or toxic, homonymous field loss
DDx: Bilateral, painful vision loss
Bacterial keratitis
Which conditions of the eye require immediate attention?
Acute central retinal artery occlusion, acute glaucoma, infectious keratitis, iritis/uveitis, hyphema, retinal detachment
Hyphema
Blood in anterior chamber
Hyphema can spontaneously occur in what population?
Diabetics
What is a sign of significant vitreous hemorrhage?
Decreased red reflex
PE: Central retinal artery occlusion
vascular narrowing, pale retina, CHERRY-RED SPOT (macula), afferent pupillary defect
What is a cause of CRAO in older patients?
Giant cell (temporal) arteritis
Onset: CRAO vs. CRVO
CRAO - acute
CRVO - subacute
PE: Central retinal vein occlusion
“Blood and thunder” fundus
SSx: Retinal detachment
Sudden onset of new floaters and black dots, photopsias, dec. red reflex, afferent pupillary defect (if macular involvement)
Etiology: acute maculopathy
severe age-related macular degeneration, diabetic retinopathy
SSx: Acute maculopathy
Central blind spot, blurred vision w/ visual distortion
Optic neuritis is associated with what other condition?
MS
SSx: Optic neuritis
Eye pain < movement, reduced visual acuity, washed-out color vision, afferent pupillary defect, normal/swollen optic disc
SSx: Papilledema
B/L optic nerve swelling w/o afferent nerve defect
Chiasmal visual field defects involve what visual fields?
Temporal
DDx: Painful red eye
corneal abrasion, foreign body, ulcer, infection, keratitis, scleritis, acute angle closure glaucoma, iritis/uveitis
DDx: Painless red eye
Subjunctival hemorrhage, conjunctivitis
Significant eye pain suggests involvement of ___
Cornea/iris b/c they are well-innervated
DDx: Red eye w/ impaired vision
Allergic, acute glaucoma, iritis, corneal dz
DDx: Abrupt onset of red eye
Trauma
Foreign body
Chemical/UV exposure
Gonococcal conjunctivitis
DDx: Subacute onset of red eye
Non-gonococcal conjunctivitis
DDx: Chronic/Persistent onset of red eye
Infection (Staph, Chlamydia, Moraxella)
DDx: Recurrent red eye
Allergic conjunctivitis, reactive arthritis
Eye discharge is suggestive of ___.
conjunctivitis
DDx: Red eye w/ photophobia
Iritis, corneal dz, acute angle closure glaucoma
What test is used to differentiate between refractive errors and serious structural disease?
Pinhole test
DDx: Location of injection
Periphery - conjunctivitis
Ciliary (perilimbal) - sign of deeper structures
Localized - foreign body, abrasion, ulcer
Margins of lid - blepharitis
What is the MC pathogen for external hordeolums (stye)?
Staph aureus
Glands involved: External vs. internal hordeolum
External - Zeiss/Moll glands
Internal - Meibomian glands
Term: Chronic internal hordeolum
Chalazion
Pain: External vs. internal hordeolum
External - more
Internal - less
What is the MC type of malignant eyelid tumor?
BCC
Papillary changes (red bumps) underneath the eyelids are suggestive of ___.
bacterial/allergic conjunctivitis
Follicular changes (pale patches) underneath the eyelids are suggestive of ___.
Chlamydia/viral conjunctivitis
DDx: Serous conjunctival d/c
Viral, allergic, toxic conjunctivitis
DDx: Mucoid conjunctival d/c
Allergic, dry eyes, blepharitis
DDx: Purulent conjunctival d/c
Bacterial
DDx: Mucopurulent conjunctival d/c
Chlamydial
SSx: Gonococcal conjunctivitis
Hyperacute onset, red/swollen eye, copious thick purulent d/c
Dx: Gonococcal conjunctivitis
Gram stain
Tx: Gonococcal conjunctivitis
REFER
SSx: Adenoviral conjunctivitis
Mild photosensitivity, morning crust w/o pain, U/L or B/L, normal vision, mildly erythematous eyelid
Which type of adenoviral conjunctivitis is more severe and presents with a foreign body sensation?
Epidemic keratoconjunctivitis
Vision: Adenoviral conjunctivitis vs. Epidemic keratoconjunctivitis
Adenoviral - normal vision
Epidemic - decreased by 2-3 lines
SSx: Bacterial conjunctivitis
Thick yellow d/c, acute onset, crusting, painless, normal cornea/anterior chamber
How to do eye irrigation
Wash medial to lateral to avoid infection of lachrymal apparatus
Herbs for bacterial conjunctivitis
Hydrastis, Berberis, Hamamelis, Fennel, Calendula, Euphrasia
Antibiotic tx for bacterial conjunctivitis
Erythromycin ophtalmic ointment
Bacterial conjunctivitis: Ars
Burning/edema, hot d/c, intense photophobia, > warmth
Bacterial conjunctivitis: Allium cepa
Streaming eyes/nose, sneezing, sore nose d/t d/c
Bacterial conjunctivitis: Euphrasia
Catarrhal conjunctivitis, constant watering of eyes, burning/acrid d/c, burning/swelling of lids, constant blinking
Bacterial conjunctivitis: Puls
Profuse yellow d/c, no excoriation, itching/burning eyes, < warm room
Course: Viral conjunctivitis
Sxs may get worse for 3-5 days and persist for 2-3 weeks
SSx: Chlamydia conjunctivitis
Doesn’t response to topical tx, follicular conjunctivitis, chemosis, lid edema, mucopurulent d/c, usu B/L, mb preauricular adenopathy
What % of pts with chlamydia conjunctivitis develop GU sxs?
60%
Tx: Chlamydia conjunctivitis
Azithromycin 1 g dose
Supplement that increases tear quality and quantity
NAC
What deficiencies can cause blepharitis?
B6, biotin, riboflavin, zinc
Dacryocystitis
Swelling/redness of lacrimal sac from infection
Supplement that may improve meibomian gland function
O3FA
Dacryostenosis
Obstruction of nasolacrimal duct
How do you assess patency of nasolacrimal duct?
Apply fluorescein to affected eye and insert cotton swab in ipsilateral nare -> dye should be visible within one minute
Violaceous hue of the eye suggests ___.
H. influenza infection
SSx: Periorbital cellulitis
Swelling/redness/pain of eyelids, acute onset, low-grade fever
NO exophthalmos, ophthalmoplegia, and visual loss
Preferred antibiotic tx of periorbital cellulitis in children
Ceftriaxone
What is the MC predisposing factor for orbital cellulitis in children?
Ethmoid sinusitis
SSx: Orbital cellulitis
Swelling/redness/pain of eyelids, acute onset, low-grade fever
PLUS diplopia, pain w/ eye movement, vision loss, proptosis, sluggish light reflex or afferent pupillary defect
Complications: Orbital cellulitis
Cavernous sinus thrombosis, brain abscess, meningitis, death
Supplement to prevent blindness in children
Vitamin A
SSx: Iritis
Eye pain, photophobia, decreased visual acuity, small/irregular pupil, ciliary injection
What is an important PE finding in iritis?
Presence of cells/flare in the anterior chamber w/ slit lamp exam (“light in fog”)
Adjunctive naturopathic tx: Iritis
Bromelain, curcumin, mydriatic drops, hydro
Patients with uveitis have lower serum levels of ___.
Zinc, Selenium
What types of drugs can exacerbate keratoconjunctivitis sicca?
Retinoids, tranquilizers, diuretics, antihypertensives, OCPs, anticholinergics
Aqueous tear-deficient keratoconjunctivitis sicca is MC found in what population?
Post-menopausal women
What test can be used to diagnose aqueous tear-deficient keratoconjunctivitis sicca?
Schirmer test
What syndrome can also cause keratoconjunctivitis sicca?
Sjogren’s syndrome
Correlations have been seen between dry eyes and ___.
IBS
What vitamin deficiencies are associated with dry eyes?
Vitamin A, D
SSx: Superficial punctate keratitis
Photophobia, foreign body sensation, lacrimation, conjunctival hyperemia, deceased visual acuity
PE: Superficial punctate keratitis
Slit lamp exam shows superficial lesions that stain with fluorescein dye
SSx: Corneal abrasion
Pain < movement, slightly blurred vision
PE: Corneal abrasion
Abrasion will produce an apple-green fluorescence under cobalt-blue light
Tx: Corneal abrasion/ulcers
Antimicrobial drops
SSx: Corneal ulcer
Pain, photophobia, visual impairment if central cornea is involved
SSx: Herpes Simplex Keratitis
Red eye, photophobia, foreign body sensation, watery d/c
PE: Herpes Simplex Keratitis
U/L, mild conjunctival injection, epithelial dendrites on slit lamp w/ fluoresceine stain
Complications: Herpes Simplex Keratitis
Vision loss, decreased corneal sensation
Tx: Herpes Simplex Keratitis
REFER
What vitamin decreases the duration of vaginal HSV sxs by 57% and TF mb helpful in Herpes Simplex Keratitis?
Vitamin C
SSx: Herpes Zoster Ophthalmicus
Pain, HA, photophobia, mb decreased visual acuity
PE: Herpes Zoster Ophthalmicus
Painful maculopapular rash w/ vesicles, Hutchinson’s sign, mb ocular involvement
PE (ocular sxs): Herpes Zoster Ophthalmicus
keratitis, uveitis, glaucoma, scleritis, optic neuritis
Hutchinson’s sign
Vesicles on the tip of the nose –> Herpes Zoster Ophthalmicus
Vitamin supplementation: Herpes Zoster Ophthalmicus
B12 (dec. post-herpetic neuralgia sxs), Vit E
Episcleritis
Inflammation of CT under conjunctiva
Acne rosacea is a less common cause of what eye condition?
Episcleritis
Eye pain: Episcleritis vs Scleritis
E - Mild
S - Severe
Onset of sxs: Episcleritis vs Scleritis
E - Sudden
S - Gradual
Visual changes: Episcleritis vs Scleritis
E - No blurred vision/photophobia
S - Blurred vision/photophobia
DDx: Episcleritis
Scelritis, Conjunctivitis
Course: Episcleritis
Resolves spontaneously within days
What is the MC known cause of scleritis
RA
SSx: Scleritis
Red eye (UL or BL), blurred vision, photophobia, significant eye pain
What is the eye pain like in scleritis?
Deep, boring, toothache-like radiating to the eyebrow/cheeks/temples
PE: Scleritis
Decreased visual acuity, localized/raised hyperemia of sclera, elevated scleral vessel,
Blanching with topical Phenylephrine: Episcleritis vs Scleritis
E - Blanches
S - Does NOT blanch
Use of topical phenylephrine is contraindicated in what condition?
Glaucoma
DDx: Scleritis
Episcleritis, conjunctivitis, iritis, acute angle-closure glaucoma
What vitamin deficiency has been associated with scleritis?
Vitamin B12
What herbs can be used for tissue repair in scleritis?
Gotu kola, bilberry
Course: Scleritis
Months-years
Complications: Scleritis
Scleral thinning or perforation, vision loss
What is the leading cause of impaired vision and blindness in the US?
Cataracts
What is the #1 surgery done per year for patients on Medicare?
Cataract
Hx: Cataract
Gradual loss of vision, difficulty driving at night
What is the significance of the red reflex in evaluating for cataracts?
If the red reflex is present, it is unlikely that the cataracts are the cause of visual problems
Risk factors: Cataracts
Ocular dz/injury/surgery, DM, Galactosemia, UV light, Smoking, Genetics, Slow acetylators
Use of what drug class has been associated with increased cataract incidence?
Statins
What is the evidence for use of antioxidants in prevention of cataracts?
NONE
What diet is associated with lower incidence of cataract?
Mediterranean
What enzyme increases polyols, which cause diabetic cataracts?
Aldose reductase
Which natural agents have been shown to inhibit aldose reductase?
Ginger, Curcumin, Quercitin, Flavonoids
If dysglycemia is a contributing factor for risk of cataracts, treat with ___.
Chromium
What herb has been used traditionally as an alterative to prevent cataracts?
Chaparral
What lymphagogue has been seen clinically to stabilize or reduce cataracts?
Cineraria maritime
What herb stopped progression of cataracts in 97% of subjects in an observational trial?
Vaccinium (bilberry)
Pathophysiology: Presbyopia/Myopia
Lens lose ability to accomodate w/ age -> loss of near vision
There is a strong association between presbyopia and increased ___.
homocysteine
Asthenopia
Weakness/fatigue of eyes
Tx: Asthenopia
Bilberry
Tx: Myopia
Vit D3, Calcium
Sxs: Acute angle closure glaucoma
Red eye, N/V, diminished vision
PE: Acute angle closure glaucoma
Perilimbal injection, cloudy cornea, narrow anterior angle, fixed/dilated pupil
Above which level is intraocular pressure associated with risk for glaucoma?
> 16 mmHg
Risk factors: Primary open-angle glaucoma
Age, darker skin, increased IOP, myopia, DM, HTN, EtOH, hypothyroid, FHx, low antioxidant status
One theory for POAG is that deficiencies in ___ lead to high intraocular levels of ___, a known neurotoxin.
Glutathione
Glutamate
Progression of vision loss in POAG?
Peripheral initially, progressing to central
PE: Primary open-angle glaucoma
Loss of peripheral fields, increased cup-disc ratio, increased IOP
What type of agents should be avoided in Primary open-angle glaucoma?
Vasoconstrictors (coffee, nicotine)
Conventional Tx: Primary open-angle glaucoma
Beta-blockers, cholinergics
MOA: Vitamin C in Primary open-angle glaucoma
Helps restore normal collagen metabolism, decreases IOP via osmotic effect
Which class of natural agents have neuroprotective and antioxidant characteristics and can be helpful in glaucoma?
Flavonoids
Eye drops of what herb have been shown to decrease IOP?
Forskolin, Fennel
Which natural agent works by increasing levels of Vitamin C, CoQ10, and Glutathione?
Alpha lipoic acid
3 Theories of Primary open-angle glaucoma pathophysiology
Mechanical (IOP), Vascular (HTN), Glutamate toxicity
What is the area of greatest visual acuity in the eye?
Macula
What % of 75 yo have some degree of ARMD?
8%
What is the MC type of ARMD?
Dry (80-95%)
Sxs: Dry ARMD
Gradual loss of vision, esp. central vision
PE: Dry ARMD
Drusen bodies are evident before onset of central vision loss
Onset: Dry vs. Wet ARMD
D - Gradual
W - Acute
Risk factors: Wet ARMD
Age, smoking, FHx, cataract surgery, HTN, obesity, hyperlipidemia, oxidative stress, Caucasian, sun exposure
ARMD is associated with ___(2).
CV risk factors, early dementia
What mineral has been shown to improve ARMD?
Zinc sulfate
What are two carotenoids found in high concentrations in the macula and mb useful in ARMD?
Lutein, Zeaxanthin
What amino acid is found in high concentrations in the retina and mb useful in ARMD?
Taurine
Blood vessels: Dry vs Wet ARMD
Dry - No new BV
Wet - New, fragile BV
Vision loss in diabetic retinopathy is secondary to __(2).
Hemorrhages -> scar tissue -> retinal detachment
What natural agent retards progression of retinopathy and partly recovers visual acuity?
Pycnogenol
Amblyopia
When a child does not use one eye
Etiology: Amblyopia
Strabismus, Congenital cataracts, refractive errors
Screening for amblyopia
Hirschberg corneal reflection test and Cover/Uncover test
SSx preceding retinal detachment
Floaters (large, dark, irregular), flashes of light, blurred vision
PE: Retinal detachment
Irregularity, folded/darkened blood vessels
Subconjunctival hemorrhage
Spontaneous hemorrhage over the sclera w/ normal vision
Tx: Subconjunctival hemorrhage
Reassurance
With blunt visual trauma, refer when ___(5)
Diminished vision, Disturbed/asymmetric pupils, Evidence of retinal damage, diplopia, hyphema
Disturbed/asymmetric pupils are a concern when the difference is >___%.
20%
Homeopathy (eye trauma): Aconite
Trauma/abrasion to eye
Homeopathy (eye trauma): Symphytum
Specific for blunt trauma to eye/orbit
Homeopathy (eye trauma): Arnica
Injuries to orbit, w/ typical arnica picture
Diminished vision in the setting of eye trauma is significant when ___ and suggests ___(3).
> 1 line decrease
corneal abrasion, retinal detachment, lens dislocation
History: Conjunctivitis vs Iritis
C - Painless, normal vision
I - Pain, decreased vision
Hordeolum
Acute focal infx of the eye involving either glands of Zeis or moll glands
Chalazion
Benign, painless, bump or nodule inside upper or lower eyelid d/t blocked oil gland
Blepharitis
Inflammation of the eyelids
Tx: Wet ARMD
VEGF inhibitor