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Pharmacology Quiz 3 > Quiz 3 > Flashcards

Quiz 3 Flashcards

1
Q

macrolides

A

antimycobacterial 2nd line

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2
Q

terbinafine

A

other antifungals

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3
Q

anidulafungin

A

Echinocardins

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4
Q

ethionamide

A

antimycobacterial 2nd line

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5
Q

erythromycin

A

macrolides/ketolides

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6
Q

posaconazole

A

azole

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7
Q

voriconazole

A

azole

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8
Q

methenamine

A

urinary tract antiseptics

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9
Q

interferon

A

antiviral ( hepatitis)

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10
Q

acydovir

A

antiviral herpes

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11
Q

ofloxacin

A

flouroquinolone

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12
Q

rifampin

A

antimycobacterial 1st line

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13
Q

flucytosine

A

Other Antifungals

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14
Q

tigecycline

A

tetracyclines

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15
Q

clarithromycin

A

macrolides/ketolides

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16
Q

Amphotericin B

A

polyene Ab

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17
Q

isoniazid

A

antimycobacterial 1st line

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18
Q

trifluridine

A

antiviral herpes

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19
Q

demeclocycline

A

tetracyclines

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20
Q

micafungin

A

Echinocardins

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21
Q

oseltamivir

A

antiviral ( Influenza)

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22
Q

cotrimoxazole

A

antifolate drugs “sulfas”

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23
Q

sulfamethoxazole

A

antifolate drugs “sulfas”

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24
Q

azithromycin

A

macrolides/ketolides

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25
Q

ethambutol

A

antimycobacterial 1st line

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26
Q

valacyclovir

A

antiviral herpes

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27
Q

caspafungin

A

Echinocardins

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28
Q

capreomycin

A

antimycobacterial 2nd line

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29
Q

gemfloxacin

A

flouroquinolone

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30
Q

gentamicin

A

aminoglycosides

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31
Q

nitrofurantoin

A

urinary tract antiseptics

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32
Q

rifabutin

A

antimycobacterial 1st line

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33
Q

telithromycin

A

macrolides/ketolides

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34
Q

ribavirin

A

antiviral ( hepatitis)

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35
Q

boceprevir

A

antiviral ( hepatitis)

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36
Q

rifapentin

A

antimycobacterial 1st line

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37
Q

moxifloxacin

A

flouroquinolone

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38
Q

chloramphenicol

A

” Others” protein synthesis Ab

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39
Q

famciclovir

A

antiviral herpes

40
Q

telaprivir

A

antiviral ( hepatitis)

41
Q

tobramycin

A

aminoglycosides

42
Q

sulfectamide

A

antifolate drugs “sulfas”

43
Q

linezolid

A

Others” protein synthesis Ab

44
Q

cidofovir

A

antiviral ( cytomegalovirus infections)

45
Q

nystatin

A

polyene Ab

46
Q

ketoconazole

A

azole

47
Q

ciprofloxacin

A

flouroquinolone

48
Q

tenofivir

A

antiviral ( hepatitis)

49
Q

fidaxomicin

A

macrolides/ketolides

50
Q

ganciclovir

A

antiviral ( cytomegalovirus infections)

51
Q

doxycycline

A

tetracyclines

52
Q

zanamivir

A

antiviral ( Influenza)

53
Q

trimethropim

A

antifolate drugs “sulfas”

54
Q

sulfadiazine

A

antifolate drugs “sulfas”

55
Q

clindamycin

A

Others” protein synthesis Ab

56
Q

minocycline

A

tetracyclines

57
Q

flouroquinolones

A

antimycobacterial 2nd line

58
Q

itraconazole

A

azole

59
Q

amikacin

A

aminoglycosides

60
Q

streptomycin

A

aminoglycosides

61
Q

norfloxacin

A

flouroquinolone

62
Q

griseofulvin

A

other antifungals

63
Q

cycloserine

A

antimycobacterial 2nd line

64
Q

pyrazinamide

A

antimycobacterial 1st line

65
Q

fluconazole

A

azole

66
Q

levofloxacin

A

flouroquinolone

67
Q

rimantadine

A

antiviral ( Influenza)

68
Q

Amantadine

A

antiviral ( Influenza)

69
Q

neomycin

A

aminoglycosides

70
Q

lamivudine

A

antiviral ( hepatitis)

71
Q
  • block viral membrane matrix protein M2
  • functions as a channel for hydrogen ions

-

A

Antiviral MoA ( respiratory)

72
Q
  • Enter Bacteria by passive diffusion
  • inhibit replication of DNA by interfering with DNA gyrase and topoisomerase IV
A

Flouroquinolones MoA

73
Q
  • active molecule targets enzymes responsible for synthesis of mycolic acid and blocks its production
  • interacts with bacterial RNA polymerase
  • decreases ic pH and inhibits growth
A

Antimicrobial Drugs 1st Line MoA

74
Q
  • interfere with the synthesis of beta glucan
  • disrupts cell wall
  • causes lysis and cell death
A

Echinocardins MoA

75
Q
  • inhibits P450 enzyme responsible for converting lanosterol to ergosterol
  • inhibits human gonadal and adrenal steroid synthesis
A

Azoles MoA

76
Q
  • reversibly bind to the 30s ribosomal subunit and prevent the binding of tRNA
  • prevents the addition of new amino acids to the growing peptide chain
  • inhibits protein synthesis
A

Tetracyclines MoA

77
Q
  • binds to 30s ribosomal subunit and interfers with initiation of protein synthesis
  • interferes with initiation complex of peptide formation
A

aminoglycosides MoA

78
Q

Binds to 50s subunit

blocks peptidyltransferase center

A

macrolides MoA

79
Q

decomposes at 5.5 or less

produces formaldehyde

toxic to bacteria

A

urinary tract antiseptics MoA

80
Q

-structural analogues of PABA

compete with dihydropterase synthetase

inhibit folate production

A

sulfanomides MoA

81
Q
  • not completely understood

thought to induce host cell enzymes to inhibit viral RNA translation

A

anitiviral MoA ( hepatic)

82
Q
  • converted to active form by viral enzyme ( thymine kinase)
  • competes as a substrate for viral DNA polymerase ans is incorp into the viral DNA
A

antiviral MoA ( herpes )

83
Q

inhibitis dihydrofolate reductase

higher affinity for bacterial enzyme than mammalian

A

Trimethoprim MoA

84
Q
  • decomposes at pH of 5.5 or less
  • produces formaldehyde which is toxic to bacteria
A

Methenamine MoA

85
Q

Damages bacterial DNA

A

Nitrofurantoin MoA

86
Q

bind to ergosterol in the plasma membrane and form a pore

this allows small molecules to escape -> cell death

A

Amphotericin B

87
Q

enters fungal cell and disrupts DNA/protein synthesis

A

Flucysotine MoA

88
Q
  • inhibits squalene epoxidase
  • blocks synthesis of ergosterol , squalene buillds up and becomes toxic
A

Terbinafine MoA

89
Q
  • inhibits fungal mitosis
  • deposited in newly forming skin protecting it from new infection
  • induces hepatic P450 activity
A

Griseofulvine MoA

90
Q
  • prodrug; activated by mycobacterial enzyme
  • active molecule targets enzymes responsible for synthesis of mycolic acid and blocks its production
A

Isoniazid MoA

91
Q

lowers ic pH and inhibits growth

A

Pyrazinimide MoA

92
Q

interferes with cell wall synthesis

A

ethambutol MoA

93
Q
  • block viral membrane protein M2

inhibits viral encoding

A

Amantadine and Rimantadine MoA

94
Q

induce host cell enzymes to inhibit viral RNA translation

A

Interferon MoA

95
Q

inhibits Hepatitis B DNA polymerase and HIV reverse transcriptase

A

Lamivudine MoA

96
Q

blocks synthesis of viral DNA and RNA

A

Ribavirin MoA

97
Q

binds to active site of Hep C Virus protease

A

Boceprevir and Telaprevir MoA

Pharmacology Quiz 3 (1 decks)

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