Quiz 3 Flashcards
- Serology: IFA, ELISA
* PCR
Bartonella henselae
• Serology
• Culture from blood (in
appropriate labs)
Brucella
• Serology: acute and
convalescent IgM/IgG
• PCR
• Elevated liver function
Chlamydia psittaci
• Serology: IFA – Compare
Phase I & Phase II Ab
• Tissue PCR
Coxiella burnetii
• Serology (may take a few
weeks to see high titers)
• PCR available some
places
Francisella tularensis
• Culture from blood, CSF, urine (slow growing) • Serology possible • Elevated liver function, thrombocytopenia
Leptospira
• Culture on blood agar
• Generally diagnosed
clinically
Pasteurella multocida
•Cellular invasion
•Suppression of immune
function (apoptosis, NFKB)
Bartonella henselae
•Replication w/in
macrophages
•Limits lysosome fusion
•Suppresses inflammation
Brucella
•Intracellular replication of
reticulate bodies
•Suppression of apoptosis
Chlamydia psittaci
•Invasion & growth in
macrophages in vacuole
•Granuloma, bacteremia
•LPS variation
Coxiella burnetii
•Escapes phagocyte vacuole
to replicate intracellularly
•Suppression of cytokines
Francisella tularensis
•Disruption of endothelial
barrier, circulation entry
•Capillary vascular damage
Leptospira
- PMT A/B subunit toxin
* Capsule sometimes
Pasteurella multocida
Capillary proliferation
bacillary angiomatosis (BA)
vascular proliferation in liver, spleen
bacillary peliosis
association of two organisms which cannot exist independently
symbiosis
association in which both organisms are benefited
mutualism
association where one partner is benefited and other is unaffected
commensalism
associations where one partner is benefited and other is harmed
disease
organisms harboring adult/sexual stage of parasite
definitive host