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Psychopharmacology Summer 21 > Quiz 3 > Flashcards

Quiz 3 Flashcards

1
Q

PK genes

A 
CYP... 
2D6
2C19
1A2
2B6
3A4
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2
Q

PD genes

A

SLC 6A4 (serotonin transporter)
5HTR2A (serotonin 2A receptor)
HLA-B 1502
HLA-A 3101

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3
Q

Ultra-rapid

A

Increased expression of metabolizing enzyme, likely low therapeutic levels since metabolizes quickly

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4
Q

Extensive

A

Normal phenotype

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5
Q

Intermediate

A

Reduced enzyme activity. Will metabolize a drug, but at a reduced rate.

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6
Q

Poor

A

Decreased or no expression of a metabolizing enzyme. Will metabolize a drug very slowly or not at all

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7
Q

Positive symptoms associated with which brain region?

A

mesolimbic/nucleus accumbens (reward circuitry/motivation)

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8
Q

Negative symptoms associated with which brain region?

A

mesocortical/prefrontal cortex; may also involve mesolimbic regions such as nucleus accumbens

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9
Q

Aggressive symptoms associated with which brain region?

A

orbitofrontal cortex; amygdala

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10
Q

Affective symptoms associated with which brain region?

A

ventromedial prefrontal cortex

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11
Q

Cognitive symptoms associated with which brain region?

A

dorsolateral prefrontal cortex

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12
Q

memantine MOA

A

NMDA antagonist-

blocks the toxic effects associated with excess glutamate, regulates glutamate activation

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13
Q

Donepezil MOA

A

(Cholestinerase inhibitor)

Prevents break down of acetylcholine in the brain

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14
Q

Rivastigmine MOA

A

(Cholestinerase inhibitor)

Prevents break down of acetylcholine and butyrylcholine in the brain

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15
Q

Galantamine MOA

A

(Cholestinerase inhibitor)
Prevents break down of acetylcholine in the brain and stimulates nicotinic receptors to release more acetylcholine in the brain

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16
Q

Gabapentin MOA

A

Binds to Alpha2Delta subunit of voltage-sensitive calcium channel; this closes the presynaptic calcium channels, diminishing excessive neuronal activity and NT release

17
Q

Pharm treatment for psych/behavioral symptoms of dementia

A

(cholinesterase inhibitors and memantine for prevention)

  1. SSRIs/SNRIs
  2. beta blockers, valproate, gabapentin, pregablin, selegiline (some might respond to carbamazepine, oxcarbazepine, benzos, buspirone, trazodone)
  3. LAST LINE= SGAs
18
Q

FGA MOA

A

Dopamine 2 receptor antagonist
Also…
Blocks H1, M1, A1 adrenergic

19
Q

2D6 metabolizes…

A 
Opiates (prodrug of codeine, hydromorphone) 
TCAs
Fluoxetine
Mirtazapine 
FGAs
Risperidone

Psychopharmacology Summer 21 (1 decks)

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