Quiz 2 - Neuro I Flashcards

1
Q

the frontal lobe contains the? which is what?

A

the frontal lobe contains the:

Primary motor area
PRECENTRAL GYRUS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

the parietal lobe contains the ? which is what?

A

primary sensory area

POSTCENTRAL GYRUS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

The cerebellum is attached to the brain stem by?

A

3 cerebellar peduncles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are gyri? fissures? and sulci?

A

gyri - buldges
fissures - large indentations
sulci - small indentations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

which CNs are sensory, motor or mixed?

A

CN I, II, VIII - sensory
CN III, IV, VI, XI, XII - motor
CN V, VII, IX, X - mixed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which tracts decussate, what do they sense, where do they cross over?

A
ASCENDING:
spinothalamic tract (pain/temp) - cross immediately.

posterior column (proprioception) - cross at junction of spinal cord and brain stem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

stepwise approach to the neurologic patient?

A

Where is the lesion?
Location, singular or multifocal (metastatic dx, ms, multiple diseases)?
is it confined to the nervous system or is it part of a systemic disorder?
what part of the nervous system is affected?
What is the lesion? (tumor, infection, hemorrhage)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the importance in asking for neurological history?

A

essential in order to localize symptoms

may need family member support in teasing out the ONSET

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

in PMhx - what different systems do we need to assess and why? what about environmental?

A

cardio - htn, cvd - assesses stroke risk
neuro - previous stroke? TIAs? psychiatric illness
endocrine - DM
hepatobiliary - liver!! could disrupt metabolism, causing systemic issues
trauma - TBI? MVA? Concussions?
systemic issues - CA? may be metastasis

HEAVY METALS - issue for neuro complaints (not something to jump to first)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

in FHx - what are important question to ask?

A

alzheimers?
parkinsons?
CVD?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the important SHx questions to assess?

A

smoking**, alcohol, drugs
sexual hx (neurosyphilis)
diet (gluten)
hobbies (exposure to heavy metals, solvents)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What ROS questions should be considered in the neurological patient?

A

Are you experiencing ANY PAIN?

HEENT
headaches, visual changes, dizziness

NEURO
tremor, weakness/sensory loss, LOC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what mental status acronym is important to know and what does it stand for? this test is also known as?

A

FOGS

  1. Family story of memory loss
  2. Orientation - time, month, day, year
  3. General Information - president of the US?
  4. Spelling - spell the word “world” forwards and backwards

this is your mini mental status exam (MMSE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

if you see hyper-reflexia where is your lesion

A

upper motor neuron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

if you see hypo-reflexia where is the lesion?

A

lower motor neuron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is the 3rd most common cause of death and most common cause of neurological disability - how do they present depending on supply? how do they present - generally?

A

cerebrovascular accident (STROKE)

anterior supply (2/3 of the brain, internal carotid) - unilateral sxs

posterior supply (1/3 of the brain, vertebrobasilar) - unilateral or bilateral, more likely to affect consciousness

generally, present SUDDENLY; CONTRALATERAL limbs, facial paralysis; confusion; h/a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the different types of stroke? what are their ssx?

A

ISCHEMIC TYPES (80%)

  • thrombic, MOST COMMON - atherosclerotic plaques, sites of turbulent blood flow, slower onset (24-48 hrs), tend to occur at NIGHT, noticed upon waking - NO H/A, PAIN OR FEVER!!
  • emobolic, SUDDEN ONSET, RAPID onset of symptoms, HEADACHE may precede neurologic defect (weakness) - AFIB, huge preceding factor.
  • lacunar - ataxia, DM, poorly controlled HTN
  • transient ischemic attack - usually precedes stroke onset by a few days/months, mini strokes, last less than an hour - DO NOT CAUSE BRAIN DAMAGE, bigger stroke is coming - WARNING SIGN

HEMORRHAGIC TYPES (20%)

  • intracerebral hemorrhage - generally due to HTN - ssx: H/A, Nausea, Impairment of consciousness
  • subarachnoid Hemorrhage - SUDDEN sever H/A with LOC, severe neurological deficits
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

How do you DX stroke?

A

BIG THING YOU WANT TO KNOW - USUALLY CLINICAL!
F - facial droop, smile, asymm?
A - arm drop, pronator drift
S - speech difficulties - repeat simple sentence
T - timing, if all above are positive - 911** likelihood of stroke is HIGH - when did they notice onset? family member may be helpful?

while waiting - assess vitals (take BP), O2 saturation (pulse ox - if losing o2 percentage, put on oxygen mask while waiting for transport).

NIHSS - typically done in the hospital, grade stroke for severity. How to ID in primary care.

Imaging - CT, done first to exclude hemorrhage. MRI done second, smaller infarcts.

IF TIME? Bedside glucose.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the different types of stroke? what are their ssx?

A

ischemic (80%)

  • thrombic, MOST COMMON - slower onset (24-48 hrs), tend to occur at NIGHT, noticed upon waking - NO H/A, PAIN OR FEVER!!
  • emobolic, SUDDEN ONSET, RAPID onset of symptoms, HEADACHE may precede neurologic defect (weakness) - AFIB, huge preceding factor.
  • lacunar - ataxia, DM, poorly controlled HTN
  • transient ischemic attack - usually precedes stroke onset by a few days/months, mini strokes, last less than an hour - DO NOT CAUSE BRAIN DAMAGE, bigger stroke is coming - WARNING SIGN

hemorrhagic (20%)

  • intracerebral hemorrhage - generally due to HTN - ssx: H/A, Nausea, Impairment of consciousness
  • subarachnoid Hemorrhage - SUDDEN severe H/A with LOC, severe neurological deficits
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

How do you DX stroke?

A

BIG THING YOU WANT TO KNOW - USUALLY CLINICAL!
F - facial droop, smile, asymm?
A - arm drop, pronator drift
S - speech difficulties - repeat simple sentence
T - timing, if all above are positive - 911** likelihood of stroke is HIGH - when did they notice onset? family member may be helpful?

while waiting - assess vitals (take BP), O2 saturation (pulse ox - if losing o2 percentage, put on oxygen mask while waiting for transport).

NIHSS - typically done in the hospital, grade stroke for severity. How to ID in primary care.

Imaging - CT, done first to exclude hemorrhage. MRI done second, smaller infarcts.

IF TIME? Bedside glucose.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How do you DX stroke?

A

BIG THING YOU WANT TO KNOW - USUALLY CLINICAL!
F - facial droop, smile, asymm?
A - arm drop, pronator drift
S - speech difficulties - repeat simple sentence
T - timing, if all above are positive - 911** likelihood of stroke is HIGH - when did they notice onset? family member may be helpful?

while waiting - assess vitals (take BP), O2 saturation (pulse ox - if losing o2 percentage, put on oxygen mask while waiting for transport).

NIHSS - typically done in the hospital, grade stroke for severity. How to ID in primary care.

Imaging - CT, done first to exclude hemorrhage. MRI done second, smaller infarcts.

IF TIME? Bedside glucose.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

which CN is helpful in assessing a frontal lobe lesion?

A

CN I tested - change in personality may also be present

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

what are key tests, assessing upper motor neuron weakness?

A

Drift of Upper Extremity
- hands in front, palms up held flat 15-30 seconds. (+), palm rotates in and pronate midline

Hand Grasp and Toe Dorsiflexion
- weakness is commonly seen in UMN lesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

what are the two tests for meningeal irritation and how are they performed?

A

kernig
- (+) straightening of lower extremity causes low back pain

brudzinski
- (+) - supine pt, passively flex pt’s head, hips will involuntarily flex

25
what is "bedside glucose"?
this is a neurological diagnostic procedure done because blood sugar dysregulation can mimic neurological conditions since glucose is the brain's food supply
26
what imaging is ordered for neurological cases?
CT - used acutely MRI - more specific, not acute Lumbar puncture - last option
27
Dementia affects mainly
memory
28
Delirium affects mainly
attention
29
Delirium affects mainly
attention
30
How does dementia present?
slow and gradual usually permanent initially unimpaired, until severe no immediate need for medical attention
31
How does delirium present?
``` sudden onset reversible attention is greatly impaired variable level of consciousness Immediate need for medical attention ``` - both of these are worse in the evening
32
delirium is typically caused by ___, often ___, most common in ___
acute illness reversible MC in the elderly
33
SSX of delirium
difficulty focusing, fluctuating consciousness, confusion, personality changes
34
what is required for dx of delirium?
``` acute change in cognition difficulty focusing plus 1 of the following - altered level of consciousness - disturbance of consciousness ```
35
What does "I WATCH DEATH" stand for? Helps with dx of delirium
``` infectious withdrawal acute metabolic disorder trauma CNS path hypoxia deficiencies endocrinopathies acute vascular toxins heavy metals ```
36
What does "I WATCH DEATH" stand for? Helps with dx of delirium
``` infectious withdrawal acute metabolic disorder trauma CNS path hypoxia deficiencies endocrinopathies acute vascular toxins heavy metals ```
37
What are the 5 most common types of dementia
``` Alzheimer's Disease Vascular Dementia Lewi Body Dementia/Parkinson' Disease HIV-associated Dementia Frontotemporal Dementia ```
38
what is commonly the first sign of dementia?
short-term memory loss
39
what do you need for dx of dementia?
history - MSE | PE - complete neuro exam
40
What labs would be ordered for dementia?
``` TSH B12 CBC LFTs HIV/RPR - if suspected ```
41
what imaging would be ordered for dementia?
CT - acute | MRI - nonacute
42
what is the diagnostic criteria for dementia?
Requires ALL 3 of the following: - cognitive sxs that interfere with the ability to complete daily activities (with 2 of the following: amnesia, language dysfxn (aphasia), can't recognize faces (agnosia), impaired reasoning (apraxia), changes in personality) - obvious decline from previous - sxs not explained by psychiatric etiology
43
what is the diagnostic criteria for dementia?
Requires ALL 3 of the following: - cognitive sxs that interfere with the ability to complete daily activities (with 2 of the following: amnesia, language dysfxn (aphasia), can't recognize faces (agnosia), impaired reasoning (apraxia), changes in personality) - obvious decline from previous - sxs not explained by psychiatric etiology
44
what is the most common cause of dementia (60-80%)
Alzheimer's Disease | - elderly (>65)
45
what is the most common cause of dementia (60-80%)
Alzheimer's Disease | - elderly (>65)
46
which genetic incidence is highly correlated with Alzheimers and occurs by the age of 35
Trisomy 21 - Down's Syndrome Patients
47
what protein is pathopneumonically deposited in Alzheimer's brain, when is this formed, during the processing of _____?
protein beta-amyloid formed during APP amyloid precursor protein processing -inappropriate deposition of this in the brain causes degeneration
48
what two proteins contribute to the processing of amyloid precursor protein (APP)
presenilin 1 & 2
49
what two proteins contribute to the processing of amyloid precursor protein (APP)
presenilin 1 & 2
50
what is the most common risk factor for alzheimer's disease
advanced age
51
what is the most common risk factor for alzheimer's disease
advanced age
52
what is the first sign of alzheimer's disease?
loss of short term memory
53
What are required for the Dx of Alzheimer's (KNOW)
``` Dementia - clinically dx'd vis MSE deficits in > 2 areas of cognition gradual onset, progressive memory and cognitive decline no disturbance of consciousness onset after age 40, most after 65 no systemic/brain disorders present ```
54
what is the 2nd most common dementia among the elderly? what are common etiologies
Vascular Dementia | for this one, think vascular diseases - HTN, DM, Smoking, Hyperlipidemia
55
What is characteristic of Lewy Body Dementia
gait instability occurs early quick onset tremor, occurs late symmetric fluctuating cognitive function - aka, hallucinations, sleep disorders, etc
56
What is characteristic of Parkinson's Disease Dementia
motor symptoms more severe | motor precedes cognitive symptoms by up to 10-15 years
57
which form of dementia tends to occur in younger individuals?
HIV-associated Dementia
58
which dementia affects personality, behavior and usually language function, more?
Frontotemporal Dementia | - occurs 55-65 (younger)
59
patient ptc with dementia, urinary incontinence and a gait disturbance that is termed "magnetic gait" - characteristic of this disorder - what is it?
Normal Pressure Hydrocephalus