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Pharm 2 > Quiz 2 > Flashcards

Quiz 2 Flashcards

1
Q

What is MAC?

A

minimum alveolar concentration- concentration required to keep 50% of humans from moving in response to painful stimulus

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2
Q

Blood gas coefficient of desflurane

A

0.42

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3
Q

Blood gas coefficient of sevoflurane

A

0.69

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4
Q

MAC of NO2

A

104

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5
Q

Blood gas coefficient/MAC/oil gas coefficient of NO2

A

0.46/104/1.4

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6
Q

Blood gas coefficient/MAC/oil gas coefficient of halothane

A

2.54/0.75/224

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7
Q

Blood gas coefficient/MAC/oil gas coefficient of isoflurane

A

1.46/1.2/98

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8
Q

Blood gas coefficient/MAC/oil gas coefficient of desflurane

A

0.42/6/18.7

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9
Q

Blood gas coefficient/MAC/oil gas coefficient of sevoflurane

A

0.69/2/55

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10
Q

ED 95 (level at which 95% of patients do not respond)

A

1.3x MAC

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11
Q

ED 95 (level at which 95% of patients do not respond)

A

1.3x MAC

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12
Q

What is blood:gas solubility?

A

ex) iso has coefficient of 1.4, so 1.4x as much gas stays in blood as goes out to tissue to have anesthetic effect (considered very soluble, stays in blood longer for effect)

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13
Q

Explain difference between higher and lower blood solubility

A

higher- slower uptake by brain and slower induction onset (more agent dissolved in blood, slow rise of alveolar partial pressure) lower- faster uptake by brain and faster induction onset (less agent dissolved in blood, alveolar partial pressure rises faster)

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14
Q

What is oil:gas solubility an indicator of?

A

potency (the higher the solubility, the more potent)

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15
Q

More potent drugs usually have a lower?

A

% for MAC

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16
Q

What is blood:gas solubility an indicator of?

A

speed of uptake and elimination

17
Q

What is blood:gas solubility an indicator of?

A

speed of uptake and elimination

18
Q

How do you calculate how much is left in an oxygen tank?

A

2000 psi/660 L- solve for x

19
Q

Which gases are isomers of each other?

A

enflurane and isoflurane

20
Q
A

halothane

21
Q
A

isoflurane

22
Q
A

desflurane

23
Q
A

sevoflurane

24
Q

What is the metabolite of halothane and what can it cause?

A

oxidative trifluroacetyl- liver toxicity

25
Q

What is the metabolite of sevoflurane?

A

compound A

26
Q

What is the metabolite of desflurane?

A

carbon monoxide

27
Q

Vapor pressure of desflurane

A

681 mmHg

28
Q

Vapor pressure of sevoflurane

A

160 mmHg

29
Q

What is considered high vs low solubility?

A

>1 very soluble

<1 not very soluble

Pharm 2 (7 decks)

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