Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Drug Design > Quiz 1 Flash Cards > Flashcards

Quiz 1 Flash Cards

1
Q

What are the components that make aromaticity?

A

cyclice ring systems
shared electrons conjugated by resonance
compounds are unusually stable
these compounds are flat and planar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which elements are electronegative?

A

F,O,Cl,N,Br,I,S,C,H,P,B,Si

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are Van der Waals forces?

A

weak short-range electrostatic attractive forces between uncharged molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is a molecular target?

A

fragment of a cell component interacting with a drug molecule in initial stage of a series of events leading to a measured effect.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is an example of an extracellular molecular targets?

A

Membrane bound receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is an example of a intracellular molecular target?

A

Enyzmez, proteins, DNA sites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is a covalent interaction?

A

interaction of two components via a covalent bond

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is ionic electrostatic interaction?

A

interaction of positive and negatively charged molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is Ion-Dipole interaction?

A

interaction of a charge molecule with another molecule that has a dipole of the opposite charge

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is Dipole-Dipole interactions?

A

When two molecules with a net dipole of opposite charge interaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What hydrophilic interactions?

A

when two molecules interaction that have an electronegative molecule and a hydrogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is a charge-transfer interaction?

A

pi-bond stacking allows electrons from 1 pi cloud to jup to another pi cloud

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are hydrophobic interactions?

A

van der waals forces of two hydrophobic molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is a bioisoster?

A

compound resulting from the exchange of an atom or group of atoms with another atom or group of atoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the objective of a bioisoster?

A

replacement to create a new compound with improved properties, favorable ADMET without changing molecular target.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the role of stereochemistry in Drug design?

A

changing the stereocenter of a molecule can increase/derease interaction points, change therapeutic application, activity, toxicity ect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which drug(s) have inactive stereoisomers?

A

Triprolidine and Ibuprofen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which drug losses it’s activity if switched to the other enanitomer?

A

Ritalin

19
Q

Which Drug is used for anti-malaria and it’s enantiomer is a anti-arrhymic?

A

Quinine

20
Q

Which drug has an enantiomer that opposes the drugs effect?

A

Albuterol

21
Q

Which drug is a NMDA receptor antagonist and the enantiomer has similar effect to THC?

A

Dexanabinol

22
Q

What is CADD?

A

computer aided drug design. a 3D visualation of interactions between compounds and proteins used to undertand the mode of drug binding and improve drug binding

23
Q

What are the main properties used in CADD?

A

Sterics- length, width, molar refractivity, volume
Electronic- ionization constants, atomic charges, fild resonance
Lipophilic- hydrophilich constant, partition coefficients, calculated log P values
H-Bonding- number of hydrogen bonds, # of h-bond donors

24
Q

What is structure-based drug design method?

A

improvement of a known inhibitor binding affinity to a know target binding siteby changing or adding fragments

25
Q

What is Ligand-Based drug design method?

A

Modify a compound structure to improve biological activity without knowledge of the target

26
Q

What is homology modeling method?

A

Construct atomic-resolution model of a target protein from an amino acid sequence or experimental 3D structure

27
Q

What is de novo deisgn method?

A

known protein binding side used to design a drug using fragments of molecules and functional groups

28
Q

What is high throughput screening?

A

technique for empirically discovering chemical modifiers of biological action.

29
Q

What are the two approaches to drug discovery?

A

Phenotypic looks at the effects of phenotypes and induced cells, tissues or organisms
Target based- measure effects of compounds on a purified target protein in an in vitro assay

30
Q

What is a biochemical assay?

A

Kinases and enzymes via simple ligand-receptor intractions. readily adaptable and little functional data

31
Q

What is a cell-based assay?

A

functional data collected via ino-channels and other membrane receptors. Harder to adapt to mini HST format

32
Q

What is homogeneous assay?

A

all components of assay in solution phase at time of detection. whas steps not needed

33
Q

What is heterogeneous assay?

A

one or more assay components in solid phase at time of detection. wash steps involved

34
Q

What is a “hit”

A

activity discovered by primary assay high-throughput screening

35
Q

What is a “lead”

A

activity confirmed in a secondary assay that is typically a more functional end point

36
Q

what is a “lead candidate”

A

show activity in animals promising pharacology

37
Q

what is a “drug”

A

are lead candidates that have effective activity in humans

38
Q

What is scintillation Proximit Assay

A

Scintillation bead with kinase attachment is brought in close contact to another kinase acceptor. the interaction releases a b particle that is detected by light

39
Q

WHat is AlphaScreen?

A

two bead get close together and energy in the form of light is transfered from one bead to another.

40
Q

What is signal to noise?

A

measure of the signal strength

41
Q

What is signal to background?

A

usually calculated using control compounds by 2 fold

42
Q

What is Z’ factor?

A

representation of the SW using a score that represents a acceptable assay

43
Q

What is an organoid?

A

high throughput 3d cultur formations that feature self assembly, generated from primary tissues, induced pluripotent stem cells and cell lines, replicates normal organ function

Drug Design (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions