Quiz 1 Flashcards
Neurological changes in pregnancy (4)
- MAC is decreased.
- Epidural space becomes smaller.
- Cerebrospinal fluid volumes are decreased and epidural veins are engorged.
- Increased sensitivity to local anesthetics.
REspiratory changes in pregnancy (net, rate, TV, MV, FRC, PaCO2)
Net effect is increased ventilation.
- Tidal volume increased ~40% at term.
- Respiratory rate increased ~15%.
- Minute ventilation increased ~50%.
- FRC decreases by ~20%
PaCO2 decreased to 28-32 mm Hg secondary to hyperventilation, i.e. respiratory alkalosis.
-Compensatory metabolic acidosis
P50 of hemoglobin increases from ___ to ___ mmHg.
Aids delivery of oxygen to fetus
27
30
maintain _____carbia during anesthesia. Why?
normo
decreased PaCO2 causes uterine constriction and decreased placental blood flow
cardiovascular changes in pregnancy. Why increase in volume?
- Increased plasma volume (~45%) in excess of red cell mass (RBC vol inc ~20%)
- increased cardiac output (inc 40%; 15-30% inc. HR and 30% inc. stroke volume)
- Peripheral vascular resistance drops about 15%
Inc. renin > inc. aldosterone > sodium/H20 retention
CO changes in 4 different phases of labor:
Latent Phase – inc. 15%
Active Phase – inc. 30%
Second Stage – inc. 45%
Postpartum – inc. 80%
Response to ________ drugs is blunted.
adrenergic
Supine Hypotension Syndrome
hypotension, pallor, nausea and vomiting and diaphoresis when they lie flat
These effects may be seen as early as 20 weeks gestation
Place patient in left lateral uterine tilt position
Coag changes in pregnancy: Increased? decreased? labs?
I, VII, VIII, IX, X, XII
XI, XIII
PT, PTT dec. 20%
Renal blood flow and glomerular filtration increased by about ____ by 16th week, remains elevated until delivery
50%
Hepatic changes in pregnancy
20% decrease in pseudocholinesterase levels.
Simultaneous increase in volume of distribution counters any clinically significant prolongation of NMB with succinylcholine
Fetal stores are about ___ ml of O2 and consumption is ___ ml/min
42
21
Compensatory mechanisms (redistribution, anaerobic metabolism) the fetus at term can survive ___ min of total O2 deprivation
10
Placental blood has a PaO2 of 40mm Hg, how is this compensated for?
the fetal oxy-hemoglobin dissociation curve is left shifted and the maternal curve is right shifted
how is transfer of CO2 accomplished?
simple diffusion across the placenta
Uterine blood flow represents ___% of cardiac output. 80% of this blood goes to the placenta, the rest goes to the ___________.
10 (600-700 ml per min in the parturient).
myometrium