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ClinPath > Quiz 1 > Flashcards

Quiz 1 Flashcards

1
Q

total number of circulating WBCs

A

WBC count

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2
Q

relative number of each type of WBC present in blood

A

Differential count

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3
Q

increased WBC

A

infection, neoplasia, physiologic conditions in newborn

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4
Q

immature form of neutrophils

A

bands

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5
Q

normal value of segmenters

A

0.50 - 0.70

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6
Q

normal value of lymphocytes

A

0.20 - 0.40

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7
Q

normal value of eosinophils

A

0-0.5

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8
Q

normal value of basophils

A

0-0.01

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9
Q

normal value of monocytes

A

0-0.07

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10
Q

normal value of bands

A

0-0.07

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11
Q

determination of abnormal RBC precursors

A

Bone Marrow Aspirate

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12
Q

detect WBC alterations

A

peripheral blood smear

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13
Q

uses immune reactions to identify molecules in WBC

A

Immunophenotyping

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14
Q

blood cell formation

A

hematopoiesis

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15
Q

origin of blood cells

A

pluripotential hematopoietic stem cells

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16
Q

most immature cell of the myeloid series

A

myeloblast

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17
Q

start of granule formation

A

promyelocyte

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18
Q

D shape nucleus

A

myelocyte

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19
Q

indented or kidney shaped nucleus

A

metamyelocyte

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20
Q

horse shoe or S shaped

A

band cell

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21
Q

increased in infections and extreme exercise

A

neutrophils

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22
Q

increased in parasitic infections

A

eosinophils

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23
Q

linked to IgE

A

basophils

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24
Q

releases histamine

A

mast cells

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25
Q

most immature cell of the lymphoid series

A

lymphoblast

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26
Q

types of lymphocytes

A

T and B cells

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27
Q

only immature cell that enlarges as it matures at

A

megakaryoblast

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28
Q

largest cell in the bone marrow

A

megakaryocyte

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29
Q

origin of platelets

A

megakaryocyte

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30
Q

Site the most common site of marrow aspiration

A

ASIS/PSIS

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31
Q

1st line of defense of the body

A

white blood cell

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32
Q

normal wbc count

A

5-10x10^9/L

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33
Q

normal neonate WBC count

A

18x10^9/L

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34
Q

effect of exercise to WBC count

A

increase

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35
Q

Decrease in the total leukocyte count

A

leukopenia

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36
Q

percentage of circulating neutrophils

A

2-3%

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37
Q

WBC in the blood vesl walls

A

marginal pool

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38
Q

drugs inducing neutropenia

A

Chlorpromazine, Phenothiazine and

Sulfonamides.

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39
Q

in viral infections, neutrophils are

A

decreased

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40
Q

increase in circulating leukocytes

A

leukocytosis

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41
Q

leukocytosis without tissue damage

A

physiologic leukocytosis

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42
Q

increased rate of neutrophil inflow from marrow to the circulation

A

physiologic neutrophilia

43
Q

increased neutrophils from disease

A

pathologic neutrophilia

44
Q

group of disorder that is

potentially neoplastic

A

Myeloproliferative disorder

45
Q

Non-leukemic leukocytosis

A

Leukemoid reaction

46
Q

Lack of myeloblasts in peripheral blood smear

A

Leukemoid reaction

47
Q

enzyme from mature WBC

A

Leukocyte Alkaline Phosphatase (LAP)

48
Q

LAP is increased in what condition?

A

Leukemoid reaction

49
Q

Most common etiology of lymphocytosis

A

viral infection

50
Q

occur if the total number of
lymphocytes is elevated, but its proportion is elevated in
proportion to the total WBC count

A

Relative lymphocytosis

51
Q

occur when the total number

of lymphocytes is increased in proportion

A

Absolute lymphocytosis

52
Q

WBC increased in Subacute bacterial endocarditis

A

monocyte

53
Q

dominant cell causing inflammatory

response

A

macrophages

54
Q

WBC increased in type 1 hypersensitivity

A

basophils

55
Q

Failure Of Normal Segmentation Of Granulocytic Nuclei

A

Pelger Huet Anomaly

56
Q

Nucleus Shape In Pelger Huet Anomaly

A

Dumbbell Shaped

57
Q

Non Neoplastic Condition In Severe Infection

A

Toxic Granulation

58
Q

Remnants Of rER/Free Ribosome

A

Dohle Body

59
Q

> 5 Lobes

A

Hypersegmented Neutrophil

60
Q

Anemia Associated To HYPERSEGMENTED NEUTROPHIL

A

Megaloblastic anemia

61
Q

Azurophilic inclusions in the WBC Not related to infection

A

ALDER REILLY ANOMALY

62
Q

Abnormally large granule in
leukocyte and in other granulecontaining
cell

A

CHEDIAK-HIGASHI SYNDROME

63
Q

Malignancies of white blood cells in peripheral blood

A

leukemia

64
Q

Malignancies of white blood cells in lymph nodes

A

lymphoma

65
Q

T/F Leukemia is always malignant

A

true

66
Q

leukemia with predominant blast cells

A

acute leukemia

67
Q

acute leukemia with predominant mature cells

A

monocytic leukemia

68
Q

Typical picture of leukemia

A

LEUKEMIC LEUKEMIA

69
Q

leukemia with normal WBC count

A

SUBLEUKEMIC LEUKEMIA

70
Q

Normal CBC & PBS, changes are found in the bone marrow

A

ALEUKEMIC LEUKEMIA

71
Q

most common presentation of leukemia

A

moderate to severe anemia

72
Q

leukemia with normal platelet count

A

Chronic Myelogenous Leukemia

73
Q

sudan black is positive for AML or ALL?

A

AML

74
Q

peroxidase is for what series?

A

myeloid

75
Q

leukocyte-specific estarase is positive for?

A

all granulocytes

76
Q

positive result of Non-specific Esterase

A

black granules

77
Q

marker for monocytes

A

NASD Acetate esterase

78
Q

marker for immature cells

A

Terminal Deoxynucleotidyl Transferase

79
Q

stain for immature RBCs

A

Periodic Acid Schiff

80
Q

marker for hairy cell leukemia

A

Tartrate Resistant Acid Phosphatase

81
Q

Minimally differentiated AML

A

M0

82
Q

Acute Myelocytic without maturation

A

M1

83
Q

Acute Myelocytic with maturation

A

M2

84
Q

Acute Promyelocytic, hypergranular

A

M3

85
Q

Acute Promyelocytic, hypogranular

A

M3V

86
Q

Myelomonocytic

A

M4

87
Q

Myelomonocytic with eosinophilia

A

M4-Eo

88
Q

Monocytic without maturation

A

M5A

89
Q

Monocytic with maturation

A

M5B

90
Q

Erythroleukemia

A

M6

91
Q

other name of Erythroleukemia

A

DiGuglielmo’s Syndrome

92
Q

Megakaryocytic

A

M7

93
Q

LYMPHOBLASTIC LEUKEMIA with Homogenous small blast type

A

L1

94
Q

LYMPHOBLASTIC LEUKEMIA with Heterogenous blast type

A

L2

95
Q

LYMPHOBLASTIC LEUKEMIA with Homogenous large blast type

A

L3

96
Q

L3 resembles what lmphoma

A

Burkitt’s Lymphoma

97
Q

condition wherein the only cells seen are a combination of myeloblasts and mature neutro

A

Leukemic hiatus

98
Q

Myeloid Markers

A

CD 13 and CD33

99
Q

FAB Criteria is based on

A

Morphology and Cytochemistry

100
Q

MYELOPROLIFERATIVE SYNDROMES have mutations in

A

tyrosine kinases

101
Q

chromosome seen in CML

A

PHILADELPHIA CHROMOSOME

102
Q

True increase in RBC mass with underlying cause

A

SECONDARY POLYCYTHEMIA

103
Q

Contain an acid phosphatase which is resistant to inhibition by L-tartrate

A

HAIRY CELL LEUKEMIA

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