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Biochem > Quick Reference Cards > Flashcards

Quick Reference Cards Flashcards

1
Q

What is the rate limiting enzyme for: De novo pyrimadine synthesis?

A

Carbamoyl phosphate synthase-2

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2
Q

What is the rate limiting enzyme for: De novo purine synthesis?

A

Glutamine PRPP amidotrasferase

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3
Q

What is the rate limiting enzyme for: Glycolysis?

A

Phosphofrucokinase-1 (main)

Hexokinase (all cells) + glucokinase (liver & beta cells)- (initial)
And pyruvate kinase (final)

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4
Q

What is the rate limiting enzyme for: gluconeogensis?

A

Fructose-1,6-bisphosphatase

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5
Q

What is the rate limiting enzyme for: glycogen synthesis

A

Glycogen synthase

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6
Q

What is the rate limiting enzyme for: glycogenolysis

A

Glycogen phosphorylase

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7
Q

What is the rate limiting enzyme for: TCA cycle

A

Isocitrate dehydrogenase

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8
Q

What is the rate limiting enzyme for: Hexose monophosphate shunt?

A

Glucose-6 phosphate dehydrogenase

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9
Q

What is the precursor for the purines and pyrimadine synthesis?

A

PRPP

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10
Q

What are the products of pyruvate (4)?

A

Oxaloacetate
Acetyl CoA
Lactate
Alanine

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11
Q

What is the required enzyme necessary to avoid: maple syrup urine disease?

A

Alpha-ketoacid dehydrogenase complex
Responsible for excretion of branched AA:
Isoleucine, leucine, and valine

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12
Q

What causes Orotic Aciduria?

A

Deficiency of UMP synthase (in pyrimidine synthesis)

  • -> see Orotic Acid in the urine
  • megaloblastic anemia
  • no hyperammonemia
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13
Q

What is the rate limiting enzyme for the Urea Cycle?

A

Carbamoyl phosphatase synthase 1

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14
Q

What is the rate limiting enzyme for the hexose monophosphate pathway?

A

Glucose-6 phosphate dehydrogenase

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15
Q

What is the rate limiting enzyme for fatty acid synthesis?

A

Acetyl-CoA carboxylase

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16
Q

What is the rate limiting enzyme for the beta-oxidation of fatty acids?

A

Carnitine acyltransferase

17
Q

What is the rate limiting enzyme for the synthesis of Ketone bodies?

A

HMG-CoA synthase

18
Q

What is the rate limiting enzyme for Cholesterol synthesis?

A

HMG-CoA reductase

19
Q

What is the rate limiting enzyme for the synthesis of Bile acid?

A

7 alpha-hydroxylase

20
Q

What is the rate limiting enzyme for Heme synthesis?

A

Aminolevulinate synthase

Biochem (4 decks)

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