Questions from all lectures Flashcards
Which of the following is NOT true? (set 1)
A. pharmacology is the science of interactions of chemical compounds with biological systems
B. The drug receptor is the cornerstone of pharmacology
C. Drugs are defined by actions
D. Antibodies are in increasing use as drugs
E. pharmacokinetics is the study of the absorption, distribution, biotransformation, and elimination of xenobiotics
D
Which of the following is NOT true? (set 1)
A.Most drugs have a single effect
B. Agonists and antagonists have overlapping binding sites
C. The magnitude of a drug response is influenced by its pharmacokinetics and pharmacology
D. Drug receptors are located intracellularly as well as on the cell surface
E. Allosteric modulators can have both positive and negative effects on agonists
A
Which of the following statements regarding Bmax is NOT true? (set 1)
A. Bmax is an estimated of number of receptors in a given tissue
B. Bmax values are determined through saturation binding studies
C. Bmax values are not regulated by drug treatment
D. Bmax values are independent of ligand
E. Bmax can influence downstream signaling events
C
Which of the following about allosteric ligands is false
A. Allosteric modulators bind at sites unique from the agonist (or antagonist) (set 1)
B. Negative allosteric modulators are noncompetitive
C. Positive allosteric modulators are safer than orthosteric agonists
D. There are no FDA-approved allosteric modulators
E.Allosteric modulators would also regulate inverse agonists
D
Using data below which of the following statements regarding compound 80 is incorrect (set 2)
Ki values
Muscarinic - 2
5HT2 - 20
Kappa - 100
Beta - 1000
A. At concentration of 2000nM it will occupy 90% of the Kappa oipiod receptors
B. At concentration of 0.2nM it will occupy 10% of the muscarinic receptors receptors
C. At concentration of 20nM it will occupy 50% of the 5HT2 receptors
D. At concentration of 50nM it will occupy <10% of the Beta receptors
A
Which of the following is NOT true regarding spare receptors? (set 2)
A. It is a system/tissue dependent
B. Allow a noncompetitve antagonist to look like a competitve antagonist
C. Spare receptors are independent of effector numbers
D. May differe between signaling pathways with the same receptor
C
Which of the following is NOT true regarding antagonists? (set 2)
A. Irreversible and allosteric antagonists have similar effects on the dose response
B. In the absence of spare receptors, a noncompetitive antagonist increases Emax
C. Irreversible antagonists typically bind the orthosteric site
D. antagonist affinity can be estimated using schild plot
B
Which of the following is NOT true regarding spare receptors? (set 3)
A. It is system/tissue dependent
B. Allow a noncompetitive irreversible antagonist to look like a competitive
C. spare receptors reveal functional receptor response at low receptor occupancy
D. Show the same response for all signaling pathways with the same receptor
D
Which of the following is NOT true regarding antagonists? (set 3)
A. Irreversible and allosteric antagonists have similar effects on the dose response curve of agonists
B. In the absence of spare receptors, a noncompetitve antagonist decreases the Emax
C. Irreversible antagonists typically bind the allosteric site
D. Antagonist KD values can be estimated using schild plot
C
Which receptor subtype is most likely to be involved with an extremely fast response? (set 3)
A. G- protein coupled receptors
B.Steroid hormone receptors
C. Ligand- gated receptors
D. Tyrosine kinase and cytokine receptors
E. All of the above
C
Which receptor subtype is most likely to be involved with an extremely slow response? (set 3)
A. G- protein coupled receptors
B.Steroid hormone receptors
C. Ligand- gated receptors
D. Tyrosine kinase and cytokine receptors
E. All of the above
B
Which receptor subtype is capable of modulating gene expression (set 3)
A. G- protein coupled receptors
B.Steroid hormone receptors
C. Ligand- gated receptors
D. Tyrosine kinase and cytokine receptors
E. All of the above
E
Which of the following G proteins is not matched with its primary effects (set 3)
A. Gq- activate phospholipase
B. Golf- activated guanylyl cyclase
C. Gs- stimulated adenylyl cyclase
D. Gi- inhibits adenylyl cyclase
B
Which of the following are NOT invovled in the mechanism of cellular/pharmacological tolerance of GPCR? (set 3)
A. Activation of the receptor by agonist
B. beta arrestin-mediated sequestration of the G protein subunit
C. Trafficking of the receptor to lysosome for degradation
D. Phosphorylation of the receptor by G protein couple receptor Kinases (GRKs)
B
Which is NOT a graded response (set 4)
A. Blood sugar lowering effect of insulin
B. Blood Pressure control by propranolol
C. Prevention of anaphylaxis reaction to penicillin by norepinephrine
D. Dilation of eye pupils by atropine
E. All of the above
C
