Questions 41-49

Question 1

Gentamicin

Answer 1

broad spectrum bactericidal

Enterobacter
E.Coli
Klebsiella
Citrobacter
Pseudomonal
Serratia
MRSA

Can be given concurrently with others
NOT available PO
Topical for eye infections

should be CLEAR or slightly yellow

AE:
-Rash, nausea/vomit
Black box*: Consists of
-Neurotoxicity: manifest as ototoxicity (loss of hearing/balance, tinnitus, persistent HA, paresthesias, seizures)

• Respiratory paralysis, neuromusc. weakness
• Nephrotoxicity

Question 2

Amphotericin B (Fungizone)

Answer 2

Binds to ergosterol in fungal cell membranes
Usually given IV

Different lipid formulations for reduced nephrotoxicity

• Infuse slowly to prevent cardiovascular collapse
• Admin medication (like acetaminophen) to decrease hypersensitivity reactions
• DON’T GIVE IF BUN OVER 40mg/dL or CREATININE OVER 3mg/dL

AE:

• Fever and chills
• Vomiting, HA
• Phlebitis
• Nephrotoxicity
• Hypokalemia

Assess for hearing stuff/ototoxicity

Question 3

Mebendazole for WORMS EWWWW

Answer 3

Single dose for pinworm

Other infections need 3 consecutive days of therapy

Needs to be chewed and taken with fatty meal

Question 4

Nystatin antifungal

Answer 4

Binds to sterols

Wider variety of forms than Amphtericin B

Topically for candida

PO to treat oropharyngeal candidiasis

For infants/children swab area
For adults swish for at least 2 mins

Can cause contact dermatitis, diarrhea, nausea

Question 5

Tetracycline

Answer 5

Works gram pos and neg.

May require admin 4 times/day due to short half life
Can treat acne

Can do IM but might hurt a lot

Take w/glass of water
Admin antacids 1-3 hours apart from this

AE:

• Can cause superinfections
• Irritates GI mucosa
• Teeth discoloration
• Photosensitivity

Question 6

Trimethoprim-sulfamethoxazole (Bactrim)

Answer 6

UTI DRUG

Admin with full glass of water

AE:

• Nausea/vomiting
• Caution w/ CKD
• Lab tests for agranulocytosis/thrombocytopenia
• Avoid sunlight