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CTO Quiz 1 > Questions > Flashcards

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1
Q

Cytochalsin

A

Prevents polymerization

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2
Q

Phalloidin

A

Prevents depolymerization

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3
Q

Taxol

A

Caps + end of MT

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4
Q

Colchicine

A

Prevents polymerization of MT’s

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5
Q

Vinblasine

A

Prevents Polymerization of MT’s

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6
Q

Keratin

A

Epithelia

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7
Q

GFAP

A

Glia

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8
Q

Vimentin

A

CT, Mesechyme

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9
Q

Desmin

A

Skeletal Muscle

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10
Q

Neurofilaments

A

Neurons

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11
Q

DNA condensation (small to large)

A

Helix => Nucleosome => solenoid => chromosome

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12
Q

What does cyclin do?

A

regulates cell cycle. interact with cyclin-dependent kinases .

Cyclins bound to ubiquitin tags for destruction by proteosomes

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13
Q

What happens in G1, S, G2

A

G1 - growth of cell
S - DNA replication
G2 - growth and replication of organelles

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14
Q

Checkpoints of cell cycle (what they check for)
G1
G2
M

A

G1 - looks for envirnmental signals
G2 - cell big enough? DNA replicated?
M - are chromosomes lined up

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15
Q

Role of p53

A

actives p21 when DNA is damaged

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16
Q

Types of Excretion

A

Merocrine - expel vesicles into extracellular space

Apocrine - budding off membrane
Holocrine - membrane slough off

17
Q

Collagen Synthesis

A
  1. rER ==> Golgi (adds lysine for H bonding)
  2. 3 alpha chaines make procollagen
  3. exported to cove
  4. ends cleaved to make tropocollagen
    * *lysyl oxidase needed to make fibrils (or else scurvy)
18
Q

COPI

COPII

A

COPI = signals proteins to go from Golgi to ER

COPII = signal proteins to go ER to Golgi

19
Q

Why is Mannose-6-Phosphate important

A

signals molecules to go to Lysosome

20
Q

Functions:
cis golgi
medial golgi
trans golgi

A

Cis - N terminal linked, add sugars
Medial - glycosylation
Trans - Adds sialic acid and sulfation occurs

21
Q

peroxisome function

A

beta oxidation of fatty acids

22
Q

Zonula Occludins are and attach to what

A

Tight junctions made of occludin and claudin

attach to Actin terminal
1

23
Q

Zonula Adherens

A

Adherent Junctions
Made of Cadherins, connect cells
Link to actin filaments
2

24
Q

Macula Adherens

A

Desmosome
attach to to IF’s
3

25
Q

Gap Junctions

A

Made of Connexins

4

26
Q

What is laminin

A

Very important extracellular ligands. (along with fibronectin)

Laminin is a proteoglycan

27
Q

Desmosine and Isodesmosine

A

modified AA that binds elastin with CT

28
Q

Fibrillin

A

Provides Scaffold for organization of glublar elastin molecules surrounded by fibers of fibrillin

29
Q

Where are the two enlargments in the spinal Cord?

A

C5-T1

L1-S3

CTO Quiz 1 (1 decks)

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