Question Bank

Question 1

Max dose zofran I’m hepatic impairment

Answer 1

8 mg/day

Question 2

Busulfan

Answer 2

-Alkylating agent
-pulmonary damage/ lung fibrosis
-commonly used for HCT in CML

Question 3

Marker of choice for choriocarcinoma

Answer 3

HCG

Question 4

Which enzyme metabolizes 5FU

Answer 4

Dihydropyimidine dehydrogenase

Question 5

Nabilone moa

Answer 5

Binds CB1 and CB2

CB1 causes the psychoactive effects

Question 6

Cancer pain tips

Answer 6

-avoid opioids in elderly
-avoid opioids in asthma
-nsaids can be used for moderate pain

Question 7

Interferon alpha adr

Answer 7

Thyroid

Question 8

Denosumab fx

Answer 8

Atypical femoral fx from reduced osteoclast activity- prevents bone remodeling and result in fxs

Note: bone meta fx are d/t inc osteoclast and Dec osteoblast activity

Question 9

Familial adenomatousus polyposis

Answer 9

Polys on colon, can become cancerous

Give celecoxib

Question 10

Vincristine contraindication

Answer 10

Charcot Marie tooth disease

Question 11

Acquired angioedema

Answer 11

-from B-cell lymphoproloferative disorders
-Tx with C1 inhibitor concentrate or bradykinin blocker icatibant if resistant to c1 inhibitor

Question 12

Carcinoid syndrome

Answer 12

-large releases of 5HT3 and other peptides
-can happen with Neuroendocrine tumors
-tx with octreotide

Question 13

Burkitts

Answer 13

Translocation if C-MYC gene and most common variant is t(8;14)

Question 14

Megestrol adr

Answer 14

Hyper cortisol

Question 15

Initial increase in tumor size with checkpoint inhibitor

Answer 15

This can happen in the first month due to influx of immune cells, just continue therapy