Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BCOP- Joey > Question Bank > Flashcards

Question Bank Flashcards

1
Q

Max dose zofran I’m hepatic impairment

A

8 mg/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Busulfan

A

-Alkylating agent
-pulmonary damage/ lung fibrosis
-commonly used for HCT in CML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Marker of choice for choriocarcinoma

A

HCG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which enzyme metabolizes 5FU

A

Dihydropyimidine dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Nabilone moa

A

Binds CB1 and CB2

CB1 causes the psychoactive effects

CNS and non-competitive binding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cancer pain tips

A

-avoid opioids in elderly
-avoid opioids in asthma
-nsaids can be used for moderate pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Interferon alpha adr

A

Thyroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Denosumab fx

A

Atypical femoral fx from reduced osteoclast activity- prevents bone remodeling and result in fxs

Note: bone meta fx are d/t inc osteoclast and Dec osteoblast activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Familial adenomatousus polyposis

A

Polys on colon, can become cancerous

Give celecoxib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Vincristine contraindication

A

Charcot Marie tooth disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Acquired angioedema

A

-from B-cell lymphoproloferative disorders
-Tx with C1 inhibitor concentrate or bradykinin blocker icatibant if resistant to c1 inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Carcinoid syndrome

A

-large releases of 5HT3 and other peptides
-can happen with Neuroendocrine tumors
-flushing, diarrhea, heart dx
-tx with octreotide
-dx with 5-HIAA elevation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Burkitts

A

Translocation if C-MYC gene and most common variant is t(8;14)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Megestrol adr

A

Hyper cortisol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Initial increase in tumor size with checkpoint inhibitor

A

This can happen in the first month due to influx of immune cells, just continue therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Bisphosphonates moa

A

Binds hydroxyapatite crystals within eared if remodeling bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Bisphosphonate weird ADR

A

Uveitis, conjunctivitis, scleritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Noisy breathing at death

A

Give anticholinergics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Doxorubicin weird contraindication

A

Hyperbaric oxygen therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Delayed complication of anthracycline

A

-co-enzyme Q10 deficiency, can lead to cerebellar ataxia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

NTRk

A

Neurotrophic tyrosine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Imiquimod

A

-minimal systemic absorption
-excreted in urine
-flu like symptoms, fatigue, headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Common mechanism of tumor cell resistance

A

P-glycoprotein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Pancreatic cancer itching

A

-due to high bilirubin
-use bile acid sequestrant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Contraindication to CBD

A

-allergy to sea same oil or dronabinol

Note CBD modulated effects of thc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Adrenal crisis

A

-can be caused by tki
-persistent hypotension, tachy, hyponatremia, hyperkalemia
-aggressive fluids, pressors, and IV hydrocortisone high dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Treating diarrhea pearl

A

Get stool cultures before starting loperamide

28
Q

Weird vincristine ADRs

A

-Vocal cord palsy: tx with pyridoxime or pyridostigmine
-jaw pain, trigeminal neuralgia
-VOD
-intestinal necrosis

29
Q

Gastrinoma

A

Goal is to treat symptoms and prevent complications of peptic ulcer disease: give high dose PPI

I think associated with pancreatic cancer

30
Q

Development of skin tumors while on BRAF/MEK

A

Don’t have to stop the drug, just continue and get biopsy

31
Q

Dexrazoxane adr

A

Testicular atrophy and infertility

32
Q

PegFilgrastim dosing is low body weight

A

Use wt based dosing if <45 kg

33
Q

Velcade rare adr

A

Hearing loss

34
Q

Mesna contraindication

A

Breastfeeding- benzyl etoh

35
Q

Calculating chemo doses in pediatrics

A

If BSA is less than 0.5 m2, use body weight instead

36
Q

Vincristine weird adr

A

VOD

37
Q

How might a peripheral neuropathy present

A

Foot drop

38
Q

Which 5HT3 antagonist is contraindicated in renal impairment

A

Granisetron if crcl<30

39
Q

Interferon weird adr

A

Suicidal ideation

40
Q

What does perechiae indicate

A

Myelosuppression/thrombocytopenia-plt<20k.

41
Q

Drug of choice for pheochromocytoma

A

Phenoxybenzamine

42
Q

Weird tamoxifen adr

A

Hepatotoxicity- peliosis hepatis

43
Q

When I say putting edema, dyspnea, shortness of breath, you say….

A

Cardiotoxicity- trastuzumab or anthracycline!

44
Q

5HT3 metabolism

A

2D6

45
Q

Hiccups drug combo

A

Cisplatin + dex

46
Q

Rare cetuximab adr

A

Aseptic meningitis

47
Q

Bleomycin AUC goal

A

78-101 mg*h/L

48
Q

Pyogenic granuloma

A

Pyrimidine analogs, taxanes, and EGFRs

49
Q

Cancer related fatigue

A

-Ritalin
-modafinil
-corticosteroids

50
Q

Fulvestrant weird adr

A

-Toxic epidermal necrosis (TEN)
-does NOT increase risk of endometrial cancer
-DOES increase risk of clots

51
Q

Hypertrophic pulmonary osteoarthropathy with bronchgenic carcinoma drug of choice

A

Pamidronate or zolendronate

52
Q

Gorlin syndrome

A

Nervous basal cell carcinoma syndrome

Hedgehogs

53
Q

Cisplatin adr

A

Salt wasting from renal damage, Fanconi syndrome

54
Q

Carmustine or lomustine adr

A

“Hypoxia”- think pulmonary toxicity

55
Q

Topical 5FU for which type of basal cell carcinoma

A

Superficial

Could also use imiquimod

56
Q

Biggest risk factor for severity of CRS in bite therapy

A

Disease burden

57
Q

Absolute contraindication

A

Don’t jump at relative CI or precautionary stuff

58
Q

Major tamoxifen ADR

A

Warfarin! Tamoxifen is cyp2C9 inhibitor- increases INR

59
Q

Weird taxane adr

A

Immune mediated pneumonitis / pulmonary toxicity

60
Q

Breast cancer in black women

A

-worse outcomes
-more TNBC

61
Q

Which antifungal has negative regulation of hedgehog pathway

A

Itraconazole

62
Q

Which SRRI is a 2D6 inhibitor

A

SEETRALINE!

63
Q

ICI concerns

A

-HCT- NO! GVHD
-Worsen myasthenia gravis
-don’t give with thalidomide

64
Q

Bsa equation

A

Square Root of [(ht x wt)/3600]

65
Q

Other drugs with infusion rxns

A

-Etoposide
-liposomal doxorubicin
-Asparginase
-iv iron

BCOP- Joey (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions