question bank Flashcards

1
Q

drugs side effects: ring in the ears, + abdomen pain + mild metabolic acidosis

A

aspirin

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2
Q

Wad does juvenile myoclonic epilepsy shows in EEG

A

4-6 Hz irregular poly spike n wave burst

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3
Q

Where does opiates acutely inhibit cAMP dependent protein phosphorylation in which structure

A

locus cerelus

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4
Q

Excoriation disorder is in which catergory

A

OCD and related

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5
Q

MMPI which scale catch ppl intentionally endorses items that reflect social desirability

A

Lie scale

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6
Q

Distal weakness in one limb, + muscle wasting in same distribution is wad disease

A

Amyotrophic lateral sclerosis

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7
Q

exaggerated startles response with violent myoclonus, elicit by lights or speaking loudly, myoclonic jerks seen spontaneously, which disease

A

Spongiform encephalopathy

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8
Q

Blue lips, pinpoint pupils, crackles on lung mild arhythymia

A

Codeine

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9
Q

Role of observing ego

A

mobilized defense mechanism in response to signal anxiety

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10
Q

biofeedback is wad type of mechanism

A

operant conditioning

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11
Q

Most common deficit underlying reading disorder in english speaking children is

A

pholonogical functioning

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12
Q

Core principle of motivational interviewing

A

develop discrepancy

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13
Q

Autistic mostly frequent with

A

mental retardation

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14
Q

Most common cause of meningitis in 2 year old after upper res infection

A

Haemophilus influenza

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15
Q

Object relations theory central premise is

A

The mind is inhabited` by mental representations of self and others

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16
Q
Compared these drugs, which is comparatively safer to be given with MAOI
amitrip
meperidine
tramadol
fentanyl
Dextromethorphan
A

Fentanyl

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17
Q

Which treatment modalities provides care for seriously mentally ill individuals in the community via MDT that is always around the clock

A

Assertive community treatment

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18
Q

first ethical directive after world war two

A

nuremberg code

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19
Q

diff between polymyositis and inclusion boy myositis

MG?

A

polymyositis: proximal (hips, thighs, shoulder, neck), <18
IBM: distal and proximal, >50 (most common)
MG: usually eyes, swallowing

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20
Q

dietary that may help depression

A

S-adenosyl-l-methionine (SAMe)

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21
Q

Which PD most common in severe factitious disorder

A

BPD

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22
Q

Defendants’ competency in court is

A

presume unless the issue is raised

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23
Q

Stimulant induced craving for drugs is most frequently mediated by

A

glutamate

also dopamine and gaba

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24
Q

kindling of depression is supported by which phenomena

A

recurrence without stressors

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25
Q

Most frequent causes of simultaneous bilateral facial palsies

A

borrelia burgdorferi

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26
Q

Most likely to inc risk of impairment after bereavement i 80 year old

A

sig depressive symptoms shortly after loss

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27
Q

Most common learning disorder in school

A

reading disorder

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28
Q

Basilar stroke symptoms
: limb which one
others:

A

all 4 limbs
bulbar
INO

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29
Q

lateral medullary stroke is wad

A

vertebral artery:
contralateral homonymous hemianopia (due to occipital infarction), hemisensory loss (due to thalamic infarction) and hemi-body pain (usually burning in nature and due to thalamic infarction)

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30
Q

Bupropion may show false positive in

sertraline may show false positive in

A

amphetamines

benzo

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31
Q

amitriptyline may show false positive in

trazodone ‘’

A

LSD

Amphetamines

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32
Q

pheochromocytoma most usually cause wad psych issue

A

panic attack

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33
Q

In AA most clearly productive of alcohol abstinence for AA

A

obtaining a sponsor

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34
Q

EMG for myopathy is usually

A

small, short duration motor units on needle examination

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35
Q

blood level for tricycline, which is more accurate (2)

A

protriptyline, desmipraminel nortriptyline

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36
Q

reason y naloxone can be given with buprenorphine with no issue

A

poor sublingual absorption of naloxone

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37
Q

In purging whihc electrolyte inc or dec:
K
Bicarb
Cl

A

k dec
Bicarb In
chloride dec

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38
Q

What does Addisonian crisis shows

A

Low bP, Low sugar, high K

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39
Q

Most common substance used among schizo patients are

For high school

A

nicotine

alcohol

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40
Q

Pregnant woman usually have their body area struck at the the

A

abdomen

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41
Q

Whipple’s Disease

Tropheryma whippelii can be diagnosed by

A

cerebrospinal fluid with PAS+ cells
got dec hemoglobin level, positive fat in stool
hyperpigmentation, diffused joint pain, abdo pain

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42
Q

Phototherapy and bipolar

A

can use but need vigilance and careful titration

can cause mania

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43
Q

Positive reagin antibodies is what and how to treat

A

syphylis

penicillin

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44
Q

which freud stage where child realize he or she is the child of the parent and the parents have a relationship between each other no solely as a parent

A

phalic

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45
Q

OCD has familial link with

A

tic disorder

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46
Q

Most prevalent movement disorder with elderly is

A

essential tremors

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47
Q

Moral skill that was first developed in children during 8-11

A

internalisation of parental values

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48
Q

opsoclonus myoclonus ataxia is associated with

A

sclc

breast

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49
Q

What is the defining features of mood in atypical mood disorder

A

reactive

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50
Q

Using alarm is better than desmopressin in wad

A

lower relapse rate

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51
Q

Which cancer treatment may be followed by subcortical dementia due to leukoencephalopathy

A

whole brain radiation

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52
Q

Polymorphism of which following candidates genes have been shown to be associated with harm avoidance

A

serotonin transporter

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53
Q

who do short term dynamic psychotherapy and wad they do

A

davaloo

Clarify and relentlessly confront the pt’s defense

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54
Q

according to freud what is the term for the dreams u remember upon awakening

A

manifest dream

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55
Q

which are the following stages of development has a group reached where the members are less afraid of revealing individual differences so that they can participate in experiential learning

A

Norming

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56
Q

Chronic prescription opioid use most commonly affects which hormones

A

testosterone

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57
Q

what kind of nystagmus is for cerebellopontine anglr

A

Bruns nystagmus -> slow when look at lesion, quick nystagmus when look away from lesion

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58
Q

Nystagmus that worsens on fixed visual, bilateral, presents of vertical and horizontal gaze is

A

brainstem

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59
Q

Most effect treatment for writer’s cramp is

A

botox

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60
Q

what is primary process thinking

A

focused on drives and wish fulfillment

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61
Q

why telepysh is not popular

A

psychiatrist dont like

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62
Q

Lithium with hydrothiazide will

A

lithium will inc

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63
Q

terazosin can help with

A

antidepressant induced sweats

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64
Q

Most common psych stuff in SLE

A

depression and cognitive impairment

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65
Q

Most common solid tumor in children

A

neuroblastoma

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66
Q

Most common meds that affects old ppl for falls apart from benzo

A

antidepressants

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67
Q

Mirtazapine is better than SSRI in which side effect

A

diarrhea

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68
Q

Antipsychotic that associated with decreased psych symptoms and substance use and inc abstinence

A

clozapine

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69
Q

A first seizure u 58 year old man with focal onset and sec generalisation is likely due to

A

glioblastoma

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70
Q

Major therapeutic goal in self help is

A

overcoming maladaptive behaviors

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71
Q

Which drug ca show subcortical demyelinating lesions

A

Toulene

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72
Q

What surgical procedure can help refractory epilepsy

A

electrical stimulation of vagus nerve

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73
Q

what is external validity

what threatens it

A

External validity refers to how well the outcome of a study can be expected to apply to other settings
-study population is not representative of the population to be treated

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74
Q

IN Pavlov. the dog salivates, the food and the bell

which is the conditioned stimulus

A

the bell

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75
Q

What worsen the impulse control in Parkinsons

A

Pramipexole

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76
Q

for violence death of loved one, wad is different

A

early bereavement is similar but it will be longer period

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77
Q

chronic heavy alcoholic has wad kind of electrolyte imbalance

A

hypomg and hypoPO4

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78
Q

IQ of 68 which period hardest to struggle

A

Adolescence

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79
Q

AA was created by who

A

dr bob smith and bill wilson

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80
Q

Triangulating in family therapy and psychology is…

A

Triangulation occurs when an outside person intervenes or is drawn into a conflicted or stressful relationship in an attempt to ease tension and facilitate communication. This also has splitting and scapegoating

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81
Q

skin manifestation of ecchymosis can be indicative of

A

Cushing’s

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82
Q

wad meds can be useful for male erectile dysfunction either transurethral or intracavernosal injection?

A

alprostadil

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83
Q

how to make ppl move from contemplation to preparation

A

acknowledge ambivalence and evoke motivation to change

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84
Q

Anticholinergic need to give what

A

physostigmine

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85
Q

Prisoners’ need to be given health care based on what principles

A

Treatment must be provided to those who are prevented from seeking their own health care

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86
Q

Which meds is useful in HIV dementia but potentially more toxic later in the disease

A

Methyphenidate

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87
Q

Withdrawal symptoms for heroin peak in

A

36 hours

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88
Q

in hypnosis, a pt report reduced awareness of sounds and other distractions in the therapist office, what is this component of hypnosis concentration

A

Absorption

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89
Q

What are the three component of hypnosis

A

Absorption: reduced awareness of sounds and other distractions
other two components:
dissociation: functional separation of elements of identity, memory, consciousness or motor response from mainstream of conscious awareness
Suggestibility: tendency to perceive and accept signals and information with relative suspension of customary critical judgement

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90
Q

Principle of human subject consent is essential, first plan that suggest this is

A

Nuremberg code

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91
Q

What is Belmont report, what are the 3 component

A

respect for person, beneficent and justice

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92
Q

What is the most widely used comprehensive broad rating scale for assessment of school age children due to the availability of age based and gender based norms

A

Child behavior checklist (CBCL)

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93
Q

When children demonstrate a [reference for human voices and speech

A

Birth

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94
Q

First step when determine whether or not a criminal defendant is not guilty by reason of insanity is

A

determine the legal insanity standard to be used

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95
Q

Which serve the basis of mentalisation based therapy

MBT is good for:

A

Bowlby’s attachment theory

BPD

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96
Q

What does trail making test tested?

What does Benton visual retention test ?

A

Visual attention and task switching (can check for executive functioning)
Benton: visual processing and visual memory, help identify possible learning disabilities

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97
Q

Presence of wad after a traumatic event will inc the risk of PTSD
A) depression
B) dissociation
C) intense fear

A

dissociation

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98
Q

Y lithium not very good for old ppl

A

Changes in renal clearance makes it hard to use

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99
Q

Triangulation appears and is focused on which family therapy
How abt unbalancing

A

strategic FT

structural: taking side of one family member to force change
Structural focus on role and boundaries

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100
Q

cisplatin can cause what, name three

A
  1. change in skin colour
  2. peripheral sensation pain
  3. sensation mostly loss on the position and vibration distally
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101
Q

Hypochondriasis affects which part of the brain is see in PET

A

caudate

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102
Q

Myasthenia gravis can be check antibody of

A

acetylcholine receptors

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103
Q

Theory of infant socialization, successful attachment most likely promote survival by

A

Creating a bond so adults will protect it

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104
Q

Elevated iGG in CSF and serum means what

A

Sarcoidosis

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105
Q

what history shows poor response for lithium treatment

A

mixed manic/depressed episode

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106
Q

Earliest evidence of cell loss in alzheimer is where

A

Entorhinal cortex

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107
Q

FDA says generic drugs should not significantly differ from the brand drug in

A

Bioequivalence

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108
Q

Asperger’s has more problem in which of the following learning profile

A

non verbal LD

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109
Q

What is cultural integration

A

integration is a form of cultural exchange in which one group assumes the belief and practice of another group without sacrificing the characteristics of its own culture

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110
Q

Which three TCA drugs has better anticholinergic s/e
Which is most cardio toxic
Which is least sedative

A
Variable: moderate with 
nortriptyline, 
imipramine and 
dosulepin (dothiepin) 
Marked with others

-most cardio toxic: ami and dothiepin
-least sedative: nortriptyline
Usually nortriptyline has the least side effect for a lot of things including postural hypotension, anticholinergic
desmipramine has not as serious anticholinergic s/e

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111
Q

hypothalamic hamartoma can cause

where is it

A
Seizures
Precocious (early) puberty
Hormone imbalances
Cognitive impairment
Behavioral problems
Emotional difficulties

at hypothalamus

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112
Q

Best 1st line for essential tremors , names two

A

propanolol, primidone (if pt has asthma)

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113
Q

IBS has high efficacy on wad

A

hypnosis

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114
Q

Which lobe will have failing of arms and fencing posture

A

frontal lobe

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115
Q

During spasticity, which neurotransmitter will be reduced

A

GABA and glycine

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116
Q

children physical and sexual abuse is a risk factor for which anxiety disorder

A

Panic disorder

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117
Q

Which psychotherapy make the pt into a sick role and give them permission and responsibility to recover?

A

IPT

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118
Q

What is the most frequent manifestation of acute neuro syphilis

A

stroke / meningitis

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119
Q

which vitamin will cause polyneuropathy eve if deficient or in excess

A

B6

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120
Q

DBT will teach which skill sets first

A

Mindfulness

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121
Q

thalamic stroke is due to

A

posterior cerebral artery ischemia

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122
Q

Amphetamines’ achieve stimulant effect by

A

release of catecholamine

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123
Q

Memory loss on dissociative amnesia is what type

a) semantic
b) episodic
c) anterograde
d) procedural
e) biographical

A

episodic

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124
Q

Cortical branch of posterior cerebral artery can cause:

A

homonymus hemianopia

alexia without agraphia

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125
Q

alexia without agraphia is due to which lesions

which blood vessels

A

infarct of the left occipital cortex and the splenium of the corpus callosum.
posterior cerebral artery

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126
Q

Nerve conduction study is MG is:

Acute polyneuropathy is

A

normal

For acute polyneuropathy: slowing of nerve conduction studies

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127
Q

shortest half life of SSRI

A

fluvoxamine

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128
Q

What treatment has demonstrated effectiveness in preventing future suicide in ppl with MDD that recent attempted suicide

A

CBT

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129
Q

Anterior spinal infarct can cause

A

motor and spinothalamic problems

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130
Q

What is the most predictive of positive psychotherapy outcome

A

Therapeutic alliance

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131
Q

When DSM start with multi axial system

A

DSM 3

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132
Q

Piaget explain what theory

A

How individual learn and understands the world

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133
Q

Which over teh counter drug can cause dissociation feeling

A

Dextromethorphan

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134
Q

epo proteins genotype
which dec risk of Alzheimer’s
which is the worse, and by how many times

A

E2/E3 (0.6)
E2/E2 (0.6)
E4/D+E4 (20 x)

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135
Q

Myotonic dystrophy, how does it inherit
When it usually appear
what are the non muscle symptoms (name 3)

A

autosomal dominant
during young adulthood
Other signs and symptoms of myotonic dystrophy can include cataracts, type-2 diabetes, and cardiac conduction defects (irregular electrical control of the heartbeat). Some affected men also have hormonal changes that may cause balding or infertility.

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136
Q

What is the major focus of outpatient psychotherapeutic groups for patients with schizophrenia

A

social skill development

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137
Q

Common side effect of naltrexone and disulfiram

A

Elevated liver enzyme

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138
Q

what does frame refer to in psychotherapy

A

how it is organised in terms of boundaries and consistent defining rules

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139
Q

REM is evident in which stage of development

A

In utero

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140
Q

depression inc or dec :

sleep latency
stage 3 sleep
REM sleep latency
amount of REM sleep.

A

Inc sleep latency (time to fall asleep),
reduced of stage 3 sleep (also known as deep sleep), reduced REM sleep latency (time to
REM sleep from sleep onset),
and increased amount of REM sleep.

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141
Q

Prognosis of acute inflammatory demyelinating polyneuropathy is poorest if the disease process involved wad

A

proximal axon

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142
Q

evoked potential or evoked response is used to test what

A

psychogenic blindness

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143
Q

supportive psychotherapy classically involves supporting and accepting the patient’s

A

defense mechanism

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144
Q

antimalaria pills induce or inhibits P450

A

inhibit

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145
Q

normal alpha rhythm is usually where

A

posterior dominant

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146
Q

gastric bypass surgery will have what deficiency

A

thiamine

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147
Q

agitation, paranoia and “walking on air” is which drug intoxication/withdrawal

A

dextromethorphan

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148
Q

Which substance abuse can induce behavioral disinhibition when used with xanax

A

alcohol

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149
Q

if psych say that he cannot treat someone not his expertise, what ethical principal is this

A

non maleficent

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150
Q

when ppl first realise individual difference in executive functioning

A

preschool

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151
Q

Validity scale of MMPI-2 test wad

A

test taking attitude of patient

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152
Q

Wad kind of medication class will cause worsen physiological tremors

A

corticosteriods

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153
Q

which of the following psychotherapeutic interventions is the most insight orientated

1) affirmation
2) clarification
3) advice and praise
4) empathetic listening
5) encouragement to elaborate

A

2) clarification

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154
Q

which infant temperamental stsyle is associated with eventual onset of anxiety symptoms in childhood

A

inhibited

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155
Q

biofeedback can be useful in wad (5)

A

insomnia, muscle tension, Raynaud mild to moderate severe idiopathic Raynaud disease, include tension HA, migraines, TMJ, epilepsy, asthma, arrhythmias, fecal
incondnence, HTN, and many others.

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156
Q

what can be used for meth abuse

A

bupropion

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157
Q

Most common cause of brain tumor in 65 year old

A

metastatic lung carcinoma

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158
Q

Insufficient of what hormone is associated with severe Intellectual disability

A

thyroid

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159
Q

serotonin syndrome usually need to give what first in terms of meds

A

lorazepam

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160
Q

Most common comorbid diagnosis in children with separation anxiety disorder

A

GAD

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161
Q

bupropion is better than ssri in terms of

A

less drug interactions

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162
Q

which brain part is useful treatment for primary generalised dystonia

A

globus pallidus

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163
Q

Pretend play usually appears at which part

A

toddlerhood

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164
Q

During acute initial refeeding phase of AN, which is most helpful focus of psychotherapeutic interventions with the pt

a) framing use of disordered eating behavior as a maladaptive coping mechanism
b) identifying triggers for relapse and developing plans to prevent relapse
c) exploring developmental, familial, and cultural antecedents to the illness
d) challenging cognitive distortions and negative core beliefs
d) coaching, support, and positive behavioral reinforcement

A

E) coaching, support, and positive behavioral reinforcement

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165
Q

MAOI food to avoid

A

coffee, red wine, beer(not vodka), smoked meats, cheese, chocolate, fava beans, Fermented soy products, such as soy sauce, miso, or tofu

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166
Q

primary process thinking refers to mental activity exemplified by which of the following

A

unconscious thoughts that do not maintain logical connections

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167
Q

Which molecule target in schiz help with improving cognition

A

D1 receptor agonism

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168
Q

Dantrolene how to help NMS , what mechanism

A

skeletal muscle relaxation

n skeletal muscle, Dantrium dissociates excitation-contraction coupling, probably by interfering with the release of Ca2+ from the sarcoplasmic reticulum

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169
Q

what is anaclitic depression

A

common outcome following sudden or prolonger separation of otherwise normal attached infant

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170
Q

Covet sensitization is on pairing o sexually arousing fantasies with

A

aversive fantasies

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171
Q

Negative predictive value definition

A

represents the probability that a person does not have a disease or condition, given a negative test result.

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172
Q

cognitive enhancement in schizophrenia is attributed to enhancement of NMDA receptors activities of which neurotransmitters

A

glycine

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173
Q

American Africans tend to have higher activity of which p450

A

3A4

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174
Q

myoclonic response when startled is which:

A

subacute spongiform encephalopathy SSPE

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175
Q

Acamprosate mechanism, what neurotransmitter

A

mechanism of action is uncertain, but the drug is thought to interact with neuronal NMDA receptors
glutamate

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176
Q

What substance abuse will inc prolactin

A

cocaine withdrawal
cocaine blocks dopamine reuptake and prolactin secretion is regulated, in part, by dopaminergic inhibitory mechanisms, cocaine withdrawal may induce rebound supersensitivity of prolactin secretion.

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177
Q

Cocaine mechanism of action

A

blocking the dopamine transporter, inhibiting reuptake of dopamine from the synaptic cleft into the pre-synaptic axon terminal;
blocks the serotonin transporter and norepinephrine transporter, inhibiting reuptake of serotonin and norepinephrine from the synaptic cleft into the pre-synaptic axon terminal and increasing activation of serotonin receptors and norepinephrine receptors in the post-synaptic neuron

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178
Q

ketamine mechanism of action

A

NMDA receptor antagonist

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179
Q

which is inducer or inhibitor

cipro
erythromycin
rifampicin
st john wort  
cimetidine
kavakava
cauliflower
red wine
A

cipro: inhibitor
erythromycin: inhibitor
rifampicin: inducer
st john wort: inducer
cimeditibe: inhibitor
kavakava: inhibit
cauliflower: induce
redwine: inhibit

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180
Q

ppl >65 with bipolar differ from young as they have

A

more mixed episode

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181
Q

potency definition

definition of efficacy

A

relative dose required to achieve a certain effect

Potency is the concentration (EC50) or dose (ED50) of a drug required to produce 50% of that drug’s maximal effect. Efficacy (Emax) is the maximum effect which can be expected from this drug

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182
Q

what feature suggest pathogen is west nile virus

A

monoparesis

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183
Q

What causes lobar multi hemorrhage

A

amyloid angiopathy

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184
Q

wad can cause lithium to dec

A

aminophylline
Xanthines: theophylline, caffeine
Sodium bicarbonate and sodium chloride containing products
Other: psyllium or ispaghula husk, urea, mannitol, acetazolamide

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185
Q

What scales would determine a children meets criteria for ID

A

vineland adaptive behavior scales

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186
Q

Which stage children will first exhibit the ability to recognized their thoughts and feelings are their own, and other may think differently

A

preschool age

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187
Q

which chemotherapy agent is mostly common associated with distal polyneuropathy

A

cisplatin

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188
Q

deficits of which neurocognitive skills for schiz is affected

A

working memory

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189
Q

Adverse cardiac effects of TCA is due to

A

fast sodium channels

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190
Q

arbitrary inference is based on

A

drawing a conclusion despite the absence of evidence or despite evidence to the contrary

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191
Q

Which meds are most effective in treatment of premature ejaculation

A

Of those approved for use in the United States, paroxetine seems to be the most effective.

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192
Q

For compulsive sexual behavior, the best results is seen in

A

twelve steps group

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193
Q

difference between inhalant and PCP intoxication

A

inhalant: nystagmus, depressed reflex, Incoordination, Slurred speech, Psychomotor retardation, : Hypotension, hypothermia, depressed gag reflex

PCP: Vertical/horizontal nystagmus, HTN/tachycardia, numbness or diminished responsiveness to pain, Ataxia, Dysarthria

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194
Q

Cape like loss of pain and temp sensation

A

syringomyelia

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195
Q

ibs can give wad meds

A

imipramine

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196
Q

Wad should be given if someone have laryngeal dystonia

A

benztropine IM

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197
Q

juvenile myoclonic epilepsy EEG

A

3-6 Hz generalized polyspike and wave discharge

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198
Q

Absence seizure EEG

A

It has a classic EEG finding of 3 Hz spike and wave discharges.

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199
Q

DSM 3 is different than its predecessors in

A

add descriptive diagnostic criteria

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200
Q

Evidence strongly support use of which meds for smoking cessation
but wad has the highest success rate

A

varenicline

bupropion and group therapy

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201
Q

Primary goal of supportive psychotherapy

A

stabilize the patient’s functioning and strengthen patient defense

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202
Q

how many hours do amphetamine reach peak level

A

2 hours

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203
Q

Baby with hypertonia, hyperreflexia, irritability and tremors with depressed interactive behavior is due ot mother’s addiction of

A

cocaine

Floppy baby is due to benzo: hypo tonia

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204
Q

smoking affect which antipsychotic (2)

A

clozapine and olanzapine (CYP 1a2)

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205
Q

interpersonal social rhythm therapy is for which disorder and focus on wad

A

bipolar

lifestyle regularity

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206
Q

GHB intoxication cause what

A

euphoria, increased energy, hyper-verbal, increased socialization, disinhibition,
hypersexuality, muscle relaxation

also can be date rape
Can be used by body builders

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207
Q

breast feeding super first line drug is

A

sertraline

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208
Q

which drug cause bruxism, decreased ability to orgasm

A

MDMA

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209
Q

group therapy forms

1) forming
2) Storming
3) norming
4) performing
5) adjourning

A

1) forming: setting ground rules, formalities, treating each other as strangers
2) Storming: communicate but still view themselves as individuals, resist control by group leader
3) norming: feel part of the team, accepting view point
4) performing: works in an open and trusting atmosphere
5) adjourning: assessment of the year and plans for transitioning roles and recognizing member contributions

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210
Q

naltrexone is what mechanism

A

opioid antagonist

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211
Q

what kind of sex behavior is bad in preschooler

A

mimic sex with toys

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212
Q

most common genetic abnormality for intellectual disability

inherited

A

downs

inherited: fragile x

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213
Q

Which ssri is the greatest potential in blocking p450

A

faverin

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214
Q

Klevin leven is

A

excessive amounts of sleep (hypersomnolence), (i.e., up to 20 hours a day); excessive food intake (compulsive hyperphagia); and behavioral changes such as an abnormally uninhibited sexual drive.

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215
Q

Kluver bucy is

which part of the brain damaged

A

damage to both of the anterior temporal lobes of the brain. It causes individuals to put objects in their mouths and engage in inappropriate sexual behavior.

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216
Q

to prove medical malpractice, what is the burden of proof

A

preponderance of evidence

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217
Q

Trazodone need high level for anti depressive property due to his weak affinity of

A

serotonin transporter

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218
Q

directed masturbation is useful for which sexual dysfunctions

A

female organismic disorder

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219
Q

correlation of plasma drug concentration with clinical effectiveness is best establish in which two drugs

A

clozapine, haloperidol

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220
Q

Which meds is most effective for treatment of low sexual desire in post menopausal women

A

testosterone, estrogen, Flibanserin, Bremelanotide

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221
Q

hallucinations in conversion has what quality

A

having childish, fantastic quality

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222
Q

in lithium toxicity, which part likely have permanent damage

A

cerebellum

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223
Q

contralateral leg weakness with sparing of face and arm associated with urinary incontinence and abulia are due to which type of stroke

A

ant cerebral artery

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224
Q

Most serious RTMS side effects are

A

seizure

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225
Q

first use the term schizophrenia is

A

Eugen bleuler

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226
Q

What is the absolute contraindication to use of sildenafil

A

regular use of sublingual nitroglycerin

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227
Q

most effective treatment for obstructive sleep apnea

A

positive pressure therapy

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228
Q

hypnotizability is most strongly predicted by

A

capacity for engaging in imagination

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229
Q

Which of the following stats measure the magnitude of difference between two intervention group

A

effect size

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230
Q

Seizure due to alcohol withdrawal have what feature

A

multiple episode

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231
Q

pure sensory deficit in lacunar is cuz at what area

A

lateral thalamus

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232
Q

pure motor deficit in lacunar is cuz at what area

A

posterior limb of the internal capsule

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233
Q

Which benzo is absorb quickly in po/im

A

lorazepam

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234
Q

which cognitive abilities is last to show decline in old age

A

word knowledge

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235
Q

which kind of meds can be found to have secondary cause of restless leg syndrome

A

antidepressant

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236
Q

There was a period of therapeutic optimism after which historical event

A

treatment of soldiers in world war 2

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237
Q

which is the best treatment for genitor pelvic/penetrations’ disorder

A

dilatation with graduated sized vaginal dilators

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238
Q

cheery skin presentation is which poison

A

CO

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239
Q

wad is teh lowest dose of methadone that is considered to suppress opioid drug hunger and induce cross tolerance blockage of illicit opiates

A

80-120mg

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240
Q

Which phase of life when he is likely to have experienced his first sexual attraction towards a same sex partner

A

young adolescence

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241
Q

what test can distinguish executive dysfunction from depression

A

clock drawing test

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242
Q

Lithium will have inc was independent of renal function

A

calcium

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243
Q

with sodium which is most relevant to follow up

A

platelets

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244
Q

Care giver who is sufficiently attuned and responsive to a child’s need to allow child to become aware of child’s own drives is referred to as a

A

good enough mother

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245
Q

When genital self stimulation is particularly pronounced in children

A

18-3 years

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246
Q

children developed uncontrolled movement disorder characterized by writhing movements of limbs and head turning, this is associated with

A

Streptococcus

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247
Q

Specificity

A

true negative

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248
Q

what causes Argyll Robertson Pupils

A

neurosyphilis, other AR like pupils can occur in the setting of diabetes mellitus, neurosarcoidosis, chronic alcoholism, encephalitis, multiple sclerosis, Lyme disease, or herpes zoster

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249
Q

caffeine how does it cause inc dopaminergic activity

A

adenosine receptor

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250
Q

In child abuse, wich part of brain is more likely to have reduced size

A

hippocampus

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251
Q

In REM sleep, HR inc or dec

A

inc

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252
Q

Which part of pharmacokinetics remains the most stable in individuals over 65 compared to younger people

A

absorption

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253
Q

Which neurodevelopmental disorder will have seizure only during adolescence

A

autism

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254
Q

projective test is to

A

detect presence of subtle psychotic thought process

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255
Q

in self psychology, a major cause of mental illness is

A

an inability to gratify unconscious drives

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256
Q

drugs that is good for postherpetic neuralgia

A

capsaicin

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257
Q

alexia with no agraphia is due to which lesion

A

corpus callosum

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258
Q

if for Tourette’s, antipsychotic and alpha adrenergic agonist does not help, what does

A

tetrabenazine

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259
Q

toc severity usually decrease during which age period

A

adolescents

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260
Q

increase beta frequency is due to wad meds

A

sedative (benzo)

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261
Q

When homosexuality was removed

A

dsm 3-R (1987)

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262
Q

what is the most salient features of anal phase

A

Child parent struggles the need to delay gratification of desires

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263
Q

odd in children can comorbid with which two disorder

A

ADHD and anxiety

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264
Q

Gelastic seizure (stereotyped laughing) are most commonly associated with which brain structure lesions

A

hypothalamus

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265
Q

what factors is associated with improved outcome in late life depression

A

family history of depression

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266
Q

l-methylfolate is better than folate in adjuvant treatment of depression because
What it inc and how

A

inc transfer across the blood brain barrier

IT inc serotonin, norepinephrine, dopamine via inc of tetrahydrobiopterin

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267
Q

Melanin klein is famous for wad

A

Objects relations psychotherapy: Melanie Klein (Object relations are related to drives; “ego splitting;”
infant-mother relationships; “depressive/paranoid/schizoid positions”)

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268
Q

Who do self psychology

A

Kohut

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269
Q

when the child is able to integrate the good and bad elements of the caregiver, he is said to be in wad phase

A

the depressive position

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270
Q

primary risk factor for completed suicide in medically hospitalised patient

A

lack of proper assessment of suicide risk

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271
Q

what hormone will be raised when have orgasms?

A

oxytocin

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272
Q

an effective study differs from efficacy study in which of the following

A

real world conditions

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273
Q

a drug addiction that causes a seizure that is not a withdrawal, what is it

A

meperidine (opiod)

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274
Q

standard of proof applies to civil involuntary psych commitment

A

preponderance of evidence

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275
Q

guanfacine is a wad type of meds

A

pre synaptic a-2 adrenergic receptor stimulation

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276
Q

mid life friendship characteristics

A

tend to have an urgent intense quality

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277
Q

long term wellbeing of child following a divorce depends on

A

cessation of conflict between the divorce parent

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278
Q

cluster headache, it occur during rem or non rem sleep

A

rem sleep

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279
Q

the combination of fluctuation aching pain in the lower ack, buttocks and sciatic distribution that is elicited by standing or walking and relieved by sitting with numbness in a similar distribution and loss of ankle reflexes is characteristic of which disorder

A

Spinal stenosis

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280
Q

Which meds can allow for larger daily reduction in benzo during taper from supratherapeutic doses

A

valproate

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281
Q

Paternalism can be justified by which basic ethic principals

A

beneficence

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282
Q

what hiv illness has the key work india ink

A

cryptococcosis

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283
Q

postpartum psychosis is associated with wad

A

bipolar

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284
Q

what is the following parental task first become especially important during toddlerhood

A

limit setting

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285
Q

What is the most evidence of managing irritability and aggression in children with autism

A

aripiprazole

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286
Q

what is most supportive for improving outcome in a practices in a therapeutic relationship

A

collecting feedback from patient about the treatment

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287
Q

Dementia pullistica ia a tauopathy or a alpha synuclein

A

tauopathy

same as PSP

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288
Q

in children wad is the best strategic approach in med titration

A

higher weight adjusted doses of medication

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289
Q

how to engage a person who behaves in a manipulative entitled manner

A

modeling an approach of appealing to the patient’s entitlement

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290
Q

a natural course of mania is

A

3 months

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291
Q

sleep terror onset is

A

childhood

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292
Q

how to unpair conditioned stimulus from unconditioned stimulus

A

have the people repeatedly face the conditioned stimulus without unconditioned stimulus

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293
Q

as children progress through the school age period of development they start to

A

recognize racial and ethnics stereotypes

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294
Q

varenicline mechanism

A

blocks the reinforcing effects of nicotine

partial agonist at α4β2 nicotinic acetylcholine receptors (nAChRs).

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295
Q

Charcot-Marie-Tooth disease type 1A what gene
deficit
how is it inherit

A

(a duplication) of the PMP22 gene

Autosomal dominant inheritance

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296
Q

What is second line for panic disorder

A

Imipramine and clomipramine are effective and
may be used as second-line treatment of panic
disorder.

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297
Q

what is an active metabolite of amitriptyline

A

norptriptyline

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298
Q

in HIV dementia, what associated with earlier deficits as compared to early stage Alzheimer dementia

A

processing speed

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299
Q

diagnostic reliability was achieved by standardizing which

A

diagnostic criteria

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300
Q

migraine prophylaxis

A

topiramate

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301
Q

what is the principal mechanism of termination of synaptic activity to secrete seminal fluid

A

degradation by monoamine oxidase

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302
Q

Main goal of group CBT for chronic pain is

A

to maintain function despite pain

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303
Q

When children start repeating stories of what happen in great detail

A

school age

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304
Q

8 year old with mild ID is most likley having difficulty with

A

understanding social cues

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305
Q

that offspring of older father have inc risk of

A

schizophrenia

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306
Q

upbeating nystagmus one primary gaze

A

lesion of medulla

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307
Q

Pain caused by neurogenic inflammation is mediated by wad

A

substance P

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308
Q

Enuresis

1) can the act of voluntary
2) how old the child mz b

A

1) can be voluntary

2) Children mz be more than 5 years old

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309
Q

If a child have less vocab, is due to what delay

A

semantics

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310
Q

Potentially threatening object produce a startled response before a person becomes consciously aware of them, due to what connection

A

Amygdala

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311
Q

Huntington is due to lost of what neurotransmitter

A

GABA

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312
Q

Alleic exclusion and X link inactivation can best be explained by what

A

epigenetics

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313
Q

what kind of antibodies shows most in inc risk of neuropsychiatric risk in lupus

A

antiphospholipid

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314
Q

Wad prob will inc after gender reassignment surgery

A

general health problems

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315
Q

Explain universal, indicated and selective

A

Universal: target a general public or a while population group that has not been identified on basis of individual risk (good prenatal care programs to prevent bullying in school)

Selective: target to individuals or a subgroup f a population whose risk of developing mental disorder is significantly higher than average, (bereavement support group, social support program)

Indicated: targeted to high risk individuals who are identified to have minimal but detectable signs and symptoms, foreshadowing mental disorder (parenting program for parents of presch children who display aggression)

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316
Q

bonus: vaccination is which type of intervention

A

primary

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317
Q

adult neurogenesis is found at

A

hippocampus

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318
Q

Rct ‘s most significant critique is

A

better suite provide information about efficacy than effectiveness

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319
Q

what is the strongest predictor of involvement of patient in leadership role in mental health consumer organization

A

perceived organizational empowerment

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320
Q

what meds can contribute to development of galactorrhea with pt on risperidone

A

fluoxetine

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321
Q

genetic mapping methods aim to identify disease associated variants based on

A

genetic linkage

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322
Q

inc of wad hormones is associated with lowered severity of PYSD

A

dehydroepiandrosterone (DHEA)

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323
Q

what antipsychotic is helpful in dec psychotic symptoms and adduction

A

clozapine

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324
Q

epigenetics is best defined as

A

mitotically and/or meiotically heritable changes in gene functions that cannot be explained by changes in DNA sequence

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325
Q

ALS is associated with what kind of dementia

A

frontotemporal dementia

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326
Q

wad prescription drug abuse happens the most

A

pain relivers

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327
Q

thomas szas saying mental illness is a myth because mental illness is

A

problem in living

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328
Q

The great majority of disease associated genetic variant identified by genome wide association studies occurs within

A

intronic or intergenic regions

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329
Q

uncinate fasciculus connect wat

A

anterior temporal and ventral frontal

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330
Q

Fragile X links to schiz by what kind of neurodevelopmental process

A

synaptic pruning

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331
Q

what hormone has circadian release pattern

A

cortisol

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332
Q

genome wide association studies typically assay which of the following

A

common genetic variants

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333
Q

Sex offender treatment program are usually wad kind of therapy

A

CBT

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334
Q

what is required of all psychiatrist by the American Board Psych and neurology maintenance of certification program

A

Medical knowledge

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335
Q

Signal in standard FMRI s the results of

A

changes i deoxyhemoglobin

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336
Q

what is useful in diagnosis of narcolepsy

A

multiple sleep latency test

337
Q

main goal in initial phase of IPT

A

collecting information abt patient’s significant relationship

338
Q

exercise and cognition evidence so far…

A

Although studies vary in quality, the general evidence is that physical activity aid cognition in later life

339
Q

How imprinting can lead to expression of a disease phenotype

A

Methylation of the paternal or maternal allele leads to unopposed expression of the other allele

340
Q

Evidence in omega three and cognition decline….

A

There is no benefit in preventing cognitive decline, but there may be other benefits

341
Q

Wad kind of psychology theory emphasized need to receive empathy from parents to develop own sense of worth

A

self psychology

342
Q

dorsolateral prefrontal cortex plays an important role in what activities

A

working memory

343
Q

wad is the most highly heritable mental disorder

A

autism spectrum disorder

344
Q

physicians who die by suicide is diff from normal population by

A

less likely to take antidepressants

345
Q

which type of seizure does the patient most likely have when they presented with paranoid delusions

A

complex partial

346
Q

which part of brain help in working memory

A

dorsolateral prefrontal cortex

347
Q

When does peak dopamine receptor density occur in striatu

A

adolescent

348
Q

US number one preventable cause of death

A

tobacco use disorder

349
Q

When is maximal pruning of cortical synapse occur

A

adolescence

350
Q

What is the mechanism for QTC interval prolongation related to antipsychotic meds

A

potassium channel blockade

351
Q

delirium, how does it show in EEG

A

generalized theta or delta slow-wave activity

352
Q

Name two neurotransmitters that implicated in brain reward activity

A

dopamine, GABA

353
Q

In bipolar what is the decreased functional connectivity in the brain

A

amygdala and the prefrontal cortex

354
Q

treatment of cataplexy in nacrolepsy

A

SSRI, SNRI, GHB, TCA

Not modafinil

355
Q

which part of the brain evaluates potentially harmful stimuli

A

lateral orbitofrontal

356
Q

When does grey matter volume peak

A

late childhood

357
Q

wad is needed for NMDA receptor ion channel opening,, name two

A

ligand binding and depolarization

358
Q

What is the most common course of gender dysphoria

A

resolves spontaneously by adulthood

359
Q

SSRI use in pregnancy is showed to what

A

is associated with neonatal adaption syndrome

360
Q

testing for genetic variants by analyzing thousand to millions of genetic markers in individuals with a disease and unaffected control is known as

A

genome wide association studies

361
Q

which of the molecular mechanism is best supported as a possible explanation for how early life stress could lead to development of psych illness in childhood

A

DNA methylation

362
Q

Outcome of deinstitutionalisation

A

higher ratio of mentally ill patient in prison than in hospital
A lot of homelessness

363
Q

what decreases in men undergoing andropause

A

penile rigidity

weight gain, loss of energy and decreased bone density

364
Q

Histone acetylation do wad

Histone methylation do wad

A

Acetylation, mostly relaxes chromatin structure
n to make DNA sterically accessible and
transcriptionally active. Histone acetylation activates
Histone methylation mostly mutes, Reversibly represses DNA transcription.

365
Q

Antidepressant Meds that does not have sexual side effects

A

bupropion, lexapro, mirtazapine

366
Q

Which three part of the brain when overactive produces worry/obsessive symptoms

A

thalamus, dorsolateral-prefrontal cortex, striatum

367
Q

trail making required what skill set (3)

A

attention, visual scanning, cognitive sequencing

368
Q

Which neuroimaging technologies is most useful in studying connectivity pathway in brain

A

DTI

369
Q

Which part hep with motor learning

A

basal ganglia

370
Q

Blood brain barrier is primarily composed of which of the following

A

Endothelial

371
Q

Aggression can be seen in ppl with reduced volume of which part

A

amygdala

372
Q

what dies Wisconsin card sorting test accurately measure

A

the ability to generate alternative strategy in response to feedback, abstract thinking, CF, and set shifting

373
Q

orexin is produce where

A

hypothalamus

374
Q

Cortisol peak in the

A

morning

375
Q

Dopamine neurons in which system helps with cognitive processing

A

Meso cortical

376
Q

What is self objects in Heinz Kohuts self psychology

A

Other people in the environment who preform particular functions for the self

377
Q

Neurosurgical approaches for OCD is where

The Deep brain stimulation is where

A

cortico-striatal-thalamo-cortico circuitry

The ant limb of internal capsule

378
Q

Dopamine neurons in which system helps with nucleus accumbens and addiction

A

Mesolimbic

379
Q

What is an example of a retrograde neurotransmitter

A

endocannabinoids or nitric oxide

380
Q

Case management in addiction has shown to help with

A

retention in treatment

381
Q

Patient with poor reality testing, primitive and immature defense and inadequate affect regulation is suitable for wad therapy

A

supportive

382
Q

criterion a for schizophrenia

A

delusion, hallucination, disorganized speech

383
Q

y older people have higher risk of EPSE

A

due to number of available dopamine receptors

384
Q

acetylcholine receptors found in cerebral cortex are
mostly muscarinic or nicotinic
inhibitory or excitory

A

muscarinic

both

385
Q

The evidence strongest for gene/environment interaction between maltreatment and genes for which of the followings

A

Monoamine oxidase A

386
Q

Chronotherapy is good for what kind of sleep disorder

A

circadian rhythm sleep disorder

387
Q

which atypical antipsychotic carries package of irks of QTC prolongation

A

paliperidone

388
Q

What drug can cause REM sleep behavior

A

alcohol or sedative-hypnotic withdrawal, tricyclic antidepressant (such as imipramine), or serotonin reuptake inhibitor use (such as fluoxetine, sertraline, or paroxetine) or other types of antidepressants (mirtazapine)

389
Q

what neurotransmitter has a significant role in social bonding

A

oxytocin

390
Q

Hoarding disorder most is accompanied by which mental illness

A

Depression

391
Q

what is the first step in the 12 step addiction recovery

A

admitting powerlessness over the addiction

392
Q

Wad strategies are most often linked to better outcome in treatment of depression in outpatient settings

A

The use of case managers

393
Q

Good enuf parent is attuned to the infant’s mental state by what process

A

mirroring

394
Q

abnormal emotional expression like pathological laughter is due to lesion affecting circuit involving which three

A

frontal cortex, pons, cerebellum

395
Q

exposure to light helps activating non visual retinal photoreceptors of which receptors

A

superchiasmatic nucleus

396
Q

primary psychological task of school age children is achieve which of the following

A

Competence

397
Q

5HT3 receptor is best described as

A

ligand gate ion channel

398
Q

CATIE trial shows patient abusing substance which one

A

alcohol 60%

399
Q

Which region of teh brain does morphology of neuron change the most duirng old age

A

prefrontal cortex

400
Q

What is a methologic limitations of epidemiologic cohort studies

A

loss to follow up

401
Q

what is a common form of sequence variation in the genome

A

single nucleotide polymorphism

402
Q

How to diagnose genetic issue with microdeletion

A

fluorescence in situ hybridization (FISH)

403
Q

among individuals with AN, those with binge-purge subtype are more likely than those with restrictive type to present with

A

substances use

404
Q

Federal court ruled that what s a required component of psych care in correctional institute

A

suicide prevention program

405
Q

which if the following is the gene mapping strategy that involves identification of genetic markers that co-segregate with disease phenotype

A

pedigree analysis

406
Q

animal maternal licking has profound stress reactivity of offspring, wad is the evidence exist regarding te mechanism of this effect

A

due to DNA methylation affect glucocorticoid receptor expression

407
Q

wad is the methodological advantage of genome wide association study in comparing individuals with schizophrenia to demographically matched control

A

can detect common gene variants that have small effect on disease risk

408
Q

what cause cell death in alxzheimer s

A

NMDA

409
Q

Wad antidepressant meds when taken as overdose clearly associated with seizure

A

clomipramine

410
Q

time for peak withdrawal symptoms in heroin

A

36 hours

411
Q

what is typically the first marker of impending puberty

A

acceleration of linear growth

412
Q

wad biological sampling methods is easiest to falsify

A

urine

413
Q

where ghrelin is secreted and what does it do

A

stomach, hunger

414
Q

Where leptin is secrete and wad does it do

A

adipose tissue , reduce food intake

415
Q

what electrolyte is associated with MDMA use

A

hyponat

416
Q

what can help with antipsychotic induced drooling

A

glycopyrrolate

417
Q

what happen after dopamine hydroxylase modifies dopamine

A

change into norepinephrine

418
Q

What is the potential complication of genome wife studies

A

false positive through repeated association test

419
Q

what rating scales can be self reported, screening diagnosis and finish under 5 minutes

A

patient health questionnaire

420
Q

cortisol is least active when

A

sleep onset

421
Q

gender identity is believed to be strongly influenced by wd

A

innate feeling

422
Q

panic disorder usually happen at (wad part)

A

late adolescent

423
Q

average number of years from start of mood disorder until diagnosis

A

6-8 years

424
Q

what neuroimaging is useful in Alzheimer’s

A

Single photon PET scan

425
Q

Which animal brain part has showed to have connection with fear conditioning and fear extinction?

A

medial pre frontal cortex

426
Q

Where and wad is dentate gyrus

A

Dentate gyrus is the first region where all sensory modalities merge together to form unique representations and memories that bind stimuli together, and thus, it plays a critical role in learning and memory.
part of the hippocampal formation in the temporal lobe
This is where neurogenesis is

427
Q

Where and wad is entorhinal cortex

A

plays an important role in declarative (autobiographical/episodic/semantic) memories and in particular spatial memories including memory formation, memory consolidation, and memory optimization in sleep.
At medial temporal lobe

428
Q

what predicts a better long term outcome in PTSD

A

rapid onset of symptoms

429
Q

What med when given with pain meds will decrease analgesic effect

A

fluoxetine

430
Q

highest rate of ptsd is wad incident

A

sexual assault

431
Q

when is the maximal part of axons and synapsis exists

A

infancy

432
Q

identify diffusion was described by erik Erickson is what

A

lack of continuity in how the self is experienced in relationship over time

433
Q

neuronal density ins schizophrenia

A

no change in neuronal density

434
Q

clinical exome sequencing is most useful for detection of

A

single nucleotide substitution

435
Q

what gene mapping technique is useful in detecting rare genetic variants of large effect

A

pedigree linkage analysis

436
Q

What do Kraepelin view of psych disease

A

they are categorically distinct “natural disease entity”

437
Q

Which symptoms is considered to be irreversible effect of chronic anabolic steroid

A

hirsutism

male-pattern baldness and breast development (gynecomastia) in men

438
Q

which developmental stages in psychodynamic group therapy is characterized by intimacy

A

working group

439
Q

Wheat is associated with an inc risk of depression in pt with multiple sclerosis

A

Lesion volume

440
Q

Which following infant and toddler temperamental styles has been shown to have greatest association with eventual inset of anxiety symptoms in childhood

A

inhibited

441
Q

which hormone is released during sleep but likely does not have a circadian pattern

A

growth hormone

442
Q

Lithium is readily dialyzable due to its

A

low molecular weight

443
Q

Wad is the alternative test for Babinski reflex

A

down scraping the skin

444
Q

Indels means

A

small insertion and deletions in DNA sequence

445
Q

Which of teh following vitamins is effective as an adjunt to atodepression meds

A

e D3

446
Q

in RCT, its in appropriate to include p values in a table sowing baseline characteristics of subject by treatment group because

A

any differences at baseline must be arise by chance given randomization

447
Q

Which of the following genes has been most associated with late onset alzheimers

A

APO E4

448
Q

how does the CNS respond to an acute cortical insult

A

Microglia processes retract and the cell body enlarges

449
Q

Highest prevalence of pathological laughing and crying

A

ALS

450
Q

what is the pharmalogical effect of lithium

A

Glycogen synthase kinase 3 inhibition

451
Q

What happen first on puberty

For girls wad physical thing first
For boys what physical thing first

A

increase in adrenal androgen production
The onset of puberty is associated with high GnRH pulsing, which precedes the rise in sex hormones, LH and FSH

Boys: testicles
Girls: breast (menstrual is usually 2 years after that)

452
Q

deep brain stimulations targeting what is for depression

A

subgenual cingulate cortex

453
Q

Wad plays a role in fine tuning working memory in dorsolateal prefrontal cortex

A

dopamine

454
Q

wad is the current evidence for pharmagenomis in psych practice

A

promise for clinical utility but replicated evidence about outcome is lacking

455
Q

Splice variant is best defines as

A

diff proteins encoded by the same genes

456
Q

Wad is an epigenetic cause of fragile X syndrome involves wad changes in fragile X mental retardation 1 gene

A

Methylation of CpG site of promotor region

457
Q

Wad is associated with the loss of fast conducting peripheral sensory nerves and dec sex steriod secretion that accompanies ages

A

delayed ejaculation

458
Q

Wad neural pathway is found to mediate reactive aggression

A

amygdala - hypothalamus - periductal gray

459
Q

sleep spindle density is most markedly decreased from middle age to old age in which region of the brain

A

frontal and occipital lobes

460
Q

Wad psychological treatment modalities help wt positive symptoms of schizophrenia

A

CBT

461
Q

How does positive effect of the neuroinflammatory response

A

Microglial propagation of cytokines associated with decreased psychical activity in response to a peripheral infection

462
Q

Whats the proportion of exome in human genome

A

2%

463
Q

The recognition of affective behavior by the mirror neuron system involves connections between the anterior mesial frontal cortex and the

A

insula

464
Q

When stress, cortico releasing hormone is released from which of the following

A

paraventricular nucleus

465
Q

Detection of single nucleotide variants in rare genetic disease is most likely to occur with which of the following types of genetic study

A

Exome sequencing

466
Q

When a child survive a natural disaster, which of the following social factors is most likely to be protective against developing post traumatic symptoms

A

the availability of peer support

467
Q

crossover study can inc wad aspect

A

precision (to be able to repeat the same value)

468
Q

what happen to p450 polymorphism is they are vey onz

how to check

A

have multiple copies of wild alleles

microarray assays

469
Q

Which if the following neurotransmitter plays a key role in regulating the transition between sleep and wakefulness

A

histamine

470
Q

what is metacognitive therapy

A

psychological treatment for schizophrenia that focus on social awareness and basic mental processes, with aims of helping patient understanding their own intellectual capacities, strengths and limitations

471
Q

What genetic methods best allow for analysis of rare variation in the population

A

Next Gen sequencing

472
Q

When psych dunno want to do next with this pt, and ask his supervisor what ethical principle is illustrated by this consultation

A

non maleficence

473
Q

linezolid is what

A

an MAOI

474
Q

When corticospinal tracts have completed myelination in children

A

3 years

475
Q

What is the following risk factors of ppl with persistent disease versus single depressive episode

A

sleep problems

476
Q

Plasticity in mammalian brain necessary for learning and memory is best accounted for which of the structural changes

A

Synaptic connectivity

477
Q

DNA methylation regulatory enzyme and proteins have recently been described in which intracellular features

A

mitochondria

478
Q

Wad antiepileptic is mostly free of any significant interaction with other antiepileptic

A

levetiracetam

479
Q

PHQ=9 is a validated tool to assess the severity of which following disorder

A

Major depressive

480
Q

When circadian sleep rhythms is generally established in the child, to be as the same as adults

A

6 months

481
Q

What will delay first sexual intercourse until after age 18

A

anxiety

482
Q

Wad PD in relatives can inc schizophrenia

A

schizotypal, NOT PARANOID

483
Q

MCI usually have wad neuropsych symptoms

A

depressive symptoms

484
Q

Which hypothalamic nuclei is key to integration of neural and nutrient signals with hormonal signals from small intestine pancreases, liver, adipose tissue and brain stem

A

arcuate nuclei

485
Q

What are the three things in terms of dates for premenstrual dysphoric disorder

A

present for the most time during the last week of luteal phase, remit withnin a few days after the onset of follicular phase and were absent in the week of post menses

486
Q

Glucocorticoid receptor is which of type

A

nuclear type

487
Q

When theory of the mind develop

A

4 year old

488
Q

Genders identity establish by what age

A

3 year old

489
Q

Most important protective factor in building resilience in children

A

quality of parenting

490
Q

Wad is a potent neuroprotective factor preventing neuronal cell death

A

pituitary adenylate cyclase-activating polypeptide

491
Q

Estrogen has was modulatory effects on neuroinflammation

A

dec inflammatory cytokine production

492
Q

Genetic copy number variation in individuals with severe neurodevelopmental disorder display what difference when compared to controls

A

Inc in burden of CNVs

493
Q

Which following demographic groups has the highest prevalence of depression

A

Previously married

494
Q

Wad best account high prevalence of disease, despite the fact that they are associated its marked reduction in fertility?

A

De novo mutation

495
Q

% of medical student report having suicidal thoughts

A

10%

496
Q

Which of the neurotransmitter effects wen dysfunctional, has been shown most comprehensively replicate the core symptoms of schizophrenia

A

glutamate

497
Q

Which of the following MRI technique is most likely t reveal abnormalities of ischemic stroke earliest

A

Diffusion weighted MRI

498
Q

what must be established in medical malpractice case for plaintiff to prevail

A

breach of duty causing harm

499
Q

Valproate has epigenetic properties due to effects of

A

histone deacetylase

500
Q

When does the person have mdd when have parental loss due to external cause

A

early childhood

501
Q

Absent gross negligence, dereliction of duty in a malpractice is typically established by…

A

Testimony of exert witnesses

502
Q

stria terminalis does what and where is it connected

A

defensive responding during uncertain threat anticipation whereas the amygdala may drive responding upon more acute danger.
Connected to amygdala to septal area and hypothalamus

503
Q

When children started to have a best friend

A

elementary school-age

504
Q

Histaminergic neurons that regulate sleeps originate in

A

tuberomammillary nuclei

505
Q

What is the most common cardiac abnormalities in myotonic dystrophy

A

arrhythmias, conduction disturbance

506
Q

Cortical synapse remodeling is believe it be associated with wad biological changes

A

preferential loss of excitatory synapse

507
Q

In individual with persistent pain, what neurotransmitter receptor is downregulated in the ventral striatum

A

dopamine

508
Q

Wad peptide is released in the GI system to convey satiety information in response to food intake
wad shows starvation information

A

cholecystokinin

ghrelin

509
Q

ampa receptor is stimulated by presence of

A

glutamate

510
Q

wad neurotransmitter system facilitates sexual arousal

A

dopaminergic

511
Q

In utero cannabis during neuronal development can cause wad

A

cognitive defects, low birth weight

512
Q
in older adults what happen to this:
body fat 
total body water 
hepatic blood flow 
colon transit time
A

body fat inc
total body water dec
hepatic blood flow dec
colon transit time inc

513
Q

minimal degree of legal certainty that is constitutionally required for an involuntary mental health commitment is

A

clear and convincing evidence

514
Q

wad is the role of cisregulatory elements in gene expression

A

mediators of transcriptional activities

515
Q

Aggressive behavior in pt with Alzheimer disease is most often associated with which of the following

A

concurrent psychosis

516
Q

wad illness target aquaporin 4 and wad symptoms

A

Neuromyelitis optica spectrum disorders

acute inflammation of the optic nerve (optic neuritis, ON), visual loss, and the spinal cord (myelitis)

517
Q

inflammatory cytokines mediates depression through which if the neuphysiological changes

A

inc expression of serotonin reuptake transporters

518
Q

validity is defined as

A

the instrument actually measures what it purports to measure

519
Q

what is considered a risk factor for suicide attempt in transitional aged youth with schizophrenia

A

higher level of education

520
Q

who coin he term schizo mother

A

fried fromm reichman

521
Q

wad is closely associated with dec dropout rate in outpatient psychotherapy

A

greater therapy experience

522
Q

initial learning phase of a skilled motor sequence requires the recruitment of wad system

A

corticostriatal and cortico cerebellar

523
Q

wad neurochemincal abnormalities has been described in pt with dec disorders

A

reduced circulating levels of gaba

524
Q

wad adverse effect of maintenance treatment with methadone for opioid dependence

A

hypogonadism

525
Q

wad antipsychotic meds for dementia related behavior disturbance is associated with inc risk of

A

death and stroke

526
Q

bell and pass is wad type of conditioning

A

classical conditioning

527
Q

wad factor is most important in contributing to aspects of successful aging

A

cognitive preservation

528
Q

what is the predominant site of endocannaboid receptor CB1

A

presynatic membrane

529
Q

which genetic test provides the most efficient method of sequencing all protein coding regions

A

whole exome sequencing

530
Q

which is the following in containing in sleep promoting neurons of ventrolateral preoptic nucleus

A

GABA

531
Q

ability of presch children to regulate their emotions is strongly enhanced by the development of

A

language

532
Q

wad are the three epigenetic mechanisms

A

1) DNA methylation
w) Histone modification
3) Expression regulation by mirco RNA

533
Q

social phobia, avoidance is regulated by connection between

A

amygdala and periaqueductal gray area of brainstem

534
Q

how does OCP and lamotrigine interact

A

Oral contraceptive containing estrogen dec serum level of lamotrigine

535
Q

which hormones is required to initiate the adolescent growth spurt

A

gonadal hormones and growth hormones

536
Q

What is the most common comorbidity in a pt with na anxiety disorder

A

another anxiety disorder

537
Q

In gastric by pass surgery wad usually is missing (name two)

A

thiamine and copper

538
Q

Ornithine transcarbamyase sequencing is wad

A

the most common inherited urea cycle disorder, is transmitted as an X-linked trait

539
Q

wad is the differences wit empathy from identification

A

,retaining objectivity in the relationship

540
Q

Wad neurophysiological test examine both executive and visuospatial functioning

A

clock drawing test

541
Q

How to calculate cumulative incidence

A

Cumulative incidence is calculated as the number of new events or cases of disease divided by the total number of individuals in the population at risk for a specific time interval.

542
Q

Wad risk factor is the most strongly associated with prolonged or complicated bereavement

A

male gender

543
Q

Personalised dosing according to CYP genotype is best established for

A

Tricyclic antidepressant

544
Q

Wad physical health condition ahs highest risk of suicide

A

Brain injury

545
Q

Slow wave sleep enhances the secretion of wad hormones

A

growth hormone

546
Q

Wad is teh most sensitive scan tool for MS

A

MRI

547
Q

wad focuses on providing psychoeducation, validating patent’s emotional validity and encouraging change

A

Dialectical behavior

548
Q

When does one has a widening concern for larger social system and differentiation of one’s own social, political and historical system

A

young adulthood to middle adulthood

549
Q

Wad antipsychotic is absorbed primarily through oral mucosae

A

asenapine

550
Q

Wad is the rate limiting enzyme in synthesis of norepinephrine

A

tyrosine hydroxylase

551
Q

Which cortical region is the key component of salience network

A

ant cingulate cortex

552
Q

Wad is the advantage of family based genetic association study over case control association

A

less affected by systemic population differences

553
Q

Which develop first in the first two years?

The motor or teh sensory

A

the motor develops first

554
Q

working memory is most associated win which frontal lobe

A

Dorsolateral prefrontal

555
Q

IF SSRI does not work in OCD< wad is the best evidence next for augmentation?

A

Aripiprazole

556
Q

Neural tube is formed from which

A

Ectoderm

557
Q

The neurogenic hypothesis of depression postulates that antidepressant efficacy depends on neurogensis of which areas

A

hippocampus

558
Q

Wad is a risk factor of rapid cycling bipolar disorder

A

female, hypothyroidism or menstrual cycle irregularities

559
Q

When is the optimal time to conduct amniocentesis analysis of genetic disorder

A

20 weeks

560
Q

wad forms of competency requires the highest legal threshold

A

making financial decisions

561
Q

Wad is the foundational factor that leads to successful abstinence for individuals participating in AA

A

Recognizing they are n alcoholic

562
Q

in CATIE AD, antipsychotic medication used for behavioral disturbance will have wad effects on majority participants

A

reduced suspiciousness

563
Q

the 4 process in motivational interviewing are

A

engaging, focusing, planning and evoking

564
Q

Wad memory is most dependent on medical temporal lobe

A

declarative

565
Q

wad psychotherapy focuses patient on buildings self esteem and a cohesive sense of self as well as improving interpersonal relationship in individuals with more severe psychopathology

A

supportive

566
Q

Corticosteroids can cause wad on hippocampus

A

Dec AMPA glutamate receptor signaling

567
Q

wad is the most associated increase in risk of developing Alzheimer disease with mild cognitive impairment

A

High BP

568
Q

Low birth weight is most strongly predictive if wad condition

A

ADHD

569
Q

What cation blocks NMDA receptors at resting membrane potential

A

Magnesium

570
Q

Most common cause of
paraparetic
Circumduction
Scissor

A

paraperetic: Damage to the descending corticospinal tract (eg, by a tumour), spinal cord lesions and bilateral cerebral hemisphere abnormalities.
Circumduction: stroke
Scissor: Cerebral palsy

571
Q

Wad scan best demonstrate TBI

A

DTI

572
Q

wad area of hypothalamus have been reported to play a central role in maternal behavior of mothers towards infant

A

Paraventricular

573
Q

Wad hormone suppresses amygdala during emotionally charged situations

A

oxytocin

574
Q

Energy homeostasis is regulated by leptin receptors in which brain regions

A

hypothalamus

575
Q

in biofeedback, relaxation state coincides with measured dec of

A

skin conductance

if inc, sweat gland will inc

576
Q

Wad meds is best evidence for monotherapy for bipolar depression (3)`

A

Quetiapine, lurasidone, olan+ fluoxetine combi

577
Q

wad metabolite of which hormone is a potent allosteric modulator of wad neurotransmitter and been implicated in depression

A

Progesterone’s, GABA-A

578
Q

Wad does n hexane damages

A

Peripheral nerve

579
Q

Wad does toluene damages

A

Cerebellar and cerebral myelin

580
Q

Name 4 reasons of adolescent chorea

A

Sydenham chorea
Lupus
Pregnancy
Oral contraception

581
Q

Wad test can check for dominant side of the hemisphere

Name 2

A

F mri and WADA test

582
Q

Heroin, named the effects of it
On the
Eyes

A

Miosis

583
Q

Wad scan is the most sensitive for stroke

A

MRI with dwi

584
Q

What connects the hippocampus and the hypothalamus

A

Fornix

585
Q

Name 6 syndromes that cause Autism

Which one is the most common

A

Fragile x, angel man, Rhett, neurofibromatosis type 1, tuberous sclerosis, landau kleffner

Fragile x

586
Q

Which drug will cause seizure during intoxication

A

Cocaine

PCP n amphetamine to come extend but rarer

587
Q

Which drug abuse causes stroke

A

Cocaine

588
Q
What nerves (peripheral or central) does these drugs cause damage to 
N hexane
Vincristine
Nitrous oxide 
Cinguatoxin
A

N hexane peripheral
Vincristine peripheral
Nitrous oxide central
Cinguatoxin peripheral

589
Q

Wads the perpez circuit

4 things with 4 connection

A

Hippocampus (fornix) mammillary bodies (mammillothalamic tract) thalamus (internal capsule) cingulate gyrus (Cingulum) hippocampus

590
Q

Orexin inhibits wad

A

REM sleep

591
Q

Name two things tat are most vulnerable to Chronic alcoholism

A

Cerebellar vermis

Mammillary bodies

592
Q

Spirochete more common infections are

A

Syphilis and Lyme disease (borrelia burgodorferi)

593
Q

Fastidious cuneatus is wad

A

It transmits position sense from upper extremities

594
Q

Horner syndrome
Wad are the symptoms
And wad it can appear at

Wad pathways it interrupts

A

Miosis, prosit and anhydrosis

Pan coast tumors, cervical syringomyelia, cluster headache, lateral medullary syndrome, dissection of carotid artery

Sympathetic pathways

595
Q

What is the treatment of choice for
Cytomegalovirus
Toxoplasmosis

A

Cyto : ganciclovir

Toxmo: pyrimethamine(daraprim)

596
Q

Cranial nerve at the pons

A

5,6,7,8

597
Q

Where locus cereleus is at

A

Pons

598
Q

Carbamazepine is structurally similar to wad meds

A

Imipramine

599
Q

Which two neurotransmitter project from the brain stem to the spinal cord

A

Serotonin, norepinephrine

600
Q

Huntington affects which neurotransmitter

A

GABA

601
Q

Wad substance will bind to cerebral amyloid to assist in the diagnosis of Alzheimer’s disease

A

Pittsburgh compound b

602
Q

Wad is the pattern of anal and urinary bladder sphincters

A

The internal splinter is inner gated by autonomic nervous System, the external sphincter is innervated by the peripheral nervous system

603
Q

Which two are most likely damaged by a coup contrecoup blow

A

Frontal and temporal lobe

604
Q

Lateral geniculate body lesion will cause what

A

Contra lateral homonymous hemianopia

605
Q

How does tetanus kill ppl

How about cyanide

A

Blocks release of glycine and GABA

Cyanide : poison respiratory energy pathway

606
Q

Using tryptophan containing products to sleep will cause wad

A

Eosinophils myalgia

607
Q

Wad is cowdry body

A

Intranuclear inclusions characteristics of SSPE

608
Q

Wad does SSRI do with REM Sleep

A

Dec rem sleep

609
Q

Sciatic nerve injury leads to wad weakness

A

Ankle Doris flex ion and plantar flexion

610
Q

Which structure is immediately superior to hypothalamus

A

Third ventricle

611
Q

Wad are the most powerful risk factor for hiv associated dementia

A

Anemia and weight loss

Cd 4 <200

612
Q

Wad are cortical dementia examples

Named 2

A

Alzheimer’s

Front temporal lobar degeneration

613
Q

Cherry red spot near each macula + seizure + mental retardation is wad

A

Tay sac disease deficiency in hexosaminidase A

Autosomal recessive

614
Q

Alexia without a graphics which lesion

Wad visual disturbance it will cause?

A

Left splenium of corpus callosum

Right homonymous hemianopia

615
Q

Corpus striatum consist of wAd

A

Caudate + putamen

616
Q

Lenticular consist of wad

A

Caudate and globes pallidus

617
Q

Which cytochrome p450 enzyme is predominantly present at birth

A

3a7

618
Q

What is the most common pathological findings in epilepsy

A

Hippocampus sclerosis

619
Q

What poisoning cause garlic breathe odor

A

Selenium poisoning

620
Q

How does trazodone cause activation of the CNS

A

Metabolite activity as well as inhibition of serotonin reputable in presynaptic receptors

621
Q

Narcissistic personality disorder

Which psychotherapy to use

A

Psychoanalysis and group therapy

622
Q

Name 5 drugs that cause depression

A

Alprazolam, clinicians, reserpine, oral contraceptives, Amantadine, guanethidine, hydralazine

623
Q

Wad is the mechanism of action of levodopa

A

Convert dopamine in cns and peripheral

624
Q

Wad risk factor for suicide in schizophrenia tat is different
Name at least 3

A

High social economic status, young age, early onset , greater illness insight

625
Q

Methyl alcohol likely cause which part of the brain for his hemorrhage

A

Putamen

626
Q

What gene is associated with developing psychosis after using cannabis

A

Akt1

627
Q

Anticholinergic effect is due to which neurotransmitter

A

Muscarinic

628
Q

Name two fda approved reasons for vagus nerve stimulation

A

Treatment resistant depression and refractory epilepsy

629
Q

Wad is the mechanism of ethosuximide

A

Reduced low threshold t type calcium currents

630
Q

What are the bio markers of Lew body dementia

A

Either reduced dopamine transporter uptake in the basal ganglia in SPECT or PET.
Low 123iodine MIBG update on myocardial scintigrapgy
Polysomnogram Demonstrating REM sleep without Antonia

631
Q

Pmdd wad is the diagnostic criteria

A

5 out of 11 specific symptoms in the final week before onset of menses Criteria b consist of Marked affected lability
Marked irritability
Marked depressed mood
Marked anxiety

7 in criterion c

632
Q

Name three physiological disturbance that may explain symptoms of panic

A

Elevated catecholamine in CNS
HYPOCAPNIA
decreased lactate metabolism

633
Q

Primary progressive aphasia is a subtype off

A

Frontal temporal dementia

634
Q

Persistent complex bereavement criteria time line for

Children
Adults

Wad are the three main one
Get one of the three

A

Children more than 6 months
Adults more than 12 months

Persistent yearning
Preoccupation with deceased or circumstance of their death
Extreme sorrow

635
Q

Mechanism of mirtazapine

A

Presynaptic alpha 2 adrenergic receptor antagonist

Also inc serotonin at 5ht 1a receptors
It blocks 5ht 2a hence lesser sexual side effect

636
Q

Which part of the brain is responsible for smell

3 things

A

Frontal , Limbic, temporal

637
Q

How does cannabis caused addiction

A

Release dopamine in Mesolimbic system

638
Q

Here and now technique is used in which family therapy

Which focus on blueprint of a healthy family defined system

What focused on change occurring during changed belief

A

Experiential

Structural (blue print)

Systemic approach

639
Q

Wad can be shown in pet scan on epilepsy

A

Reduced uptake of glucose on affected side

640
Q

% of people with chronic alcohol use disorder having parents with chronic alcohol use disorder

A

30%

641
Q

Venlafaxine one can cause false positive in

A

PCP

642
Q

Wad is the most significant prognosis factor for malignant supratentorial, astrocytic glioma.

A

Necrosis

643
Q

Wad is the percentage of ppl with learning disorder being male

A

60-80%

644
Q

Prion protein is usually carried on which chromosome

A

The short arm of 20

645
Q

Mechanism of baclofen

Pregabalin

Acamprosate

A

GABA b agonist

Calcium channel antagonist

Acamprosate: antagonized glutaminergic function via NMDA receptors

646
Q

Wad chromosome is associated with narcolepsy

A

6

647
Q

what chromosome for AD is for late onset

wad are early onset

A

late: 19 (EPO E)
Early: 1 (Prenesellin 1), 14 (pre 2), 21 (APP amyloid)

648
Q

prevalence of LD

A

1-3%

649
Q

What is the % of catatonia in psychosis cases in hospital

A

7-17%

650
Q

teratogenicity of valproate usually happen when

A

3-6 weeks

651
Q

% of bereave people having depression

A

20%

652
Q

Most common cause of temporal lode epilepsy

A

mesial temporal sclerosis and hippocampal sclerosis and temporal atrophy

653
Q

reactive attachment disorder, symptoms has to be how old

A

need to be before 5 years old

no need durations of the illness

654
Q

standard of proof
in civil case
in criminal case

A

civil: clear and convincing evidence
criminal: guilty beyond reasonable of a doubt

655
Q

Wad is te FDA approval for duloxetine for pain (name 2-3)

A

chronic musculoskeletal pain
diabetic nephropathy
fibromyalgia

656
Q

If QTC prolongation , TCA overdose, cardiac toxicity happen within 2 hours wad should we do

A

charcoal via NGT/oral

If >2 hours IV sodium bicarbonate

657
Q

partial seizure have ?% normal eeg

A

40%

658
Q

ziprasidone has less wad side effect (name 4)

A

hypotension, tardive dyskinesia, weight gain, increased appetite
it can cause qtc prolongation

659
Q

what tumors can cause akinetic mutism

A

tumors at the upper brainstem

660
Q

which TCU are contraindicated in breast feeding

A

doxepin (can cause sedation, hypotonia, respiratory depression)

661
Q

selegeline patch is good because

A

bypass gastric tract, no need diet restrictions

662
Q

Methyl alcohol usually damage where

A

putamen

663
Q

sleep schedule (nap time for narcolepsy)

A

20 mins 2x a day

664
Q

MAOI affect what neurotransmitters

A

serotonin, norepinephrine, dopamine

665
Q

How does clonidine works

A

binds presynaptic alpha-2 autoreceptors, decreases locus coeruleus cell firing, and reduce noradrenergic release

666
Q

Wad is made with morning glory seed

A

LSD (also ergot alkaloids and rye fungus )

667
Q

varenicline how does it work

A

alpha 4 beta 2 partial agonist of the nicotinic receptors

668
Q

Time of symptoms to reach a diagnosis:

phobia

A

6 months

669
Q

4 mechanism of buspirone

A

buspirone
5ht1a: partial agonist at postsynaptic, full agonist at presynaptic
mild dopamine antagonist at d2, d3,d4 receptor
partial alpha 1 receptor agonist

670
Q

what is the barbiturate of choice for anesthesia

A

sodium thiopenthol

671
Q

adrenoleukodystrophy symptoms:
usually when

what test use to check it

A

behavioral change and intellectual deterioration in early school years
loos of vision, deafness, dysphagia
progressive central demyelination and adrenal cortical insufficiency
coma, seizure

4-10 years old

test:
a blood test is performed to measure the levels of VLCFA.
MRI to see demyelination

672
Q

% of people with PD have depression

A

40-50%

673
Q

Chronic meningitis is defined as how long

A

4weeks

674
Q

Chromosome and wad gene cause wilson’s disease

A

chromosome 13, atp7B

675
Q

Clozapine mechanism

A

dopamine (D1,2,3), serotonin 5ht2A and alpha receptor antagonist
low potency for d2

676
Q

Friedreich ataxia start when
symptoms

How its inherited

A

Friedreich ataxia symptoms:
usually happen 5-15 years old
ataxia, motor weakness, scoliosis, dysarthria, high arches, pes cavus, diabetes (20%), muscle wasting, nystagmus, cardiac involvement
usually wheel chair bound by 15 years old

GAA trinucleotide repeat, auto recessive

677
Q

what to do for these lithium symptoms

edema
tremors
polydipsia/polyuria
for nausea

A

edema: give spironolactone (25mg a day)
tremors: propranolol, or primidone (25-100mg/day)
polydipsia/polyuria: give amiloride or hydrochlorothiazide, to cut half the lithium
for nausea: use sustained release formulation

678
Q

which brain region does leptin work as

A

hypothalamus

679
Q

Which hypothalamus area is good for maternal behavior

A

preoptic

680
Q

Which cranial nerve is for gag reflex and palate elevation

A

vagus nerve

681
Q

which forms the neural tube

A

ectoderm

682
Q

which part of brain responsible for remember a number to make a phone call

A

dorsolateral prefrontal cortex

683
Q

Which part of prain evaluates painful stimuli

A

lateral orbito frontal cortex

684
Q

here oresin is made

A

hypothalamus

685
Q

which dopaminergic pathway is charge of addiction

and is implicated in tasks related to cognitive processing

A

addiction: mesolimbic

cognitive processing: mesocortical

686
Q

normal romberg with eyes open but loses balance when eyes is close is wad

A

cerebellar vermis

687
Q

unconsciousness may be induced by a small area of damage where

A

reticulate formation

688
Q

Akinetic mutism can result in bilateral infarction of

A

anterior cingulate gyrus

689
Q

syndrome characterized by fluent speech, preserved comprehension, inability to repeat, without associated signs, where is the lesions

A

supramarginal gyrus and insula

690
Q

Area for dbs for Parkinson’s

A

subthalamic nucleus

691
Q

pathological laughter is caused by lesions affecting a system connecting three things which are

A

frontal cortex, pons and cerebellum

692
Q

card sorting test activated which part of the frontal lobes

A

dorso lateral

693
Q

which neurotransmitter is the last t mature in CNS of children

A

cholinergic

694
Q

metabolic of what modulates GABA-A as seen in depression

A

progesterone

695
Q

predominate site of endocannaboid receptor

A

presynaptic membrane

696
Q

what neurotransmitters promotes sexual arousal

A

dopamine

697
Q

what neurotransmitter has been associated with anxiety

A

norepinephrine

698
Q

which neurotransmitter maintain consistent level with age

A

serotonin

699
Q

the cognitive enhancement associated with experimental D cyclosporine treatment in pt’s with schizophrenia has been attributes to enhancement of NMDA receptor activity of which neurotransmitter

A

glycine

700
Q

what is the 5ht receptor classification

A

ligand gated

701
Q

which neurotransmitter present in periaqueductal gray matter is involved in mediation of pain

A

endorphins

702
Q

Delayed neurological deterioration following carbon monoxide induced coma is most likely manifested by

A

parkinsonism

703
Q

what WBC comes out usually when its TB

A

monocytes

704
Q

Criteria for declaration of brain death

A

apnea test

705
Q

What is a life threatening complication of cerebellar hemorrhage

A

acute hydrocephalus

706
Q

most common form of hypertensive intracranial hemorrhage

A

left putaminal hemorrhage

707
Q

Gait for stroke usually is

A

circumduction

708
Q

Abnormal elevated metabolic findings associated with in creased risk of stroke for pt under 50

A

plasma homocysteine

709
Q

As opposed to stroke caused by arterial embolism or thrombosis, those caused by cerebral vein or venous sinus thrombosis are

A

associated with seizure at onset

710
Q

subcortical dementia is suggested by which of the following in regards in patient with early stage cognitive impairment

A

preserved calculation skills

711
Q

What test best differentiate AD from frontotempora; demenia

A

SPECT scan

712
Q

Pt with vascular dementia typically have neuropathological changes associated with

A

basal ganglia

713
Q

PET scan shows bitemporoparietal hypoperfusion in early stage of which dementia

A

AD

714
Q

what is the characteristic of post lumbar puncture headache

A

worse with sitting upright

715
Q

The presence of headache, hemiparesis, symptoms of raised intracranial pressure and focal epilepsy in a relatively young patient is indicative of
with elevated d dimer

A

sagittal sinus thrombosis

716
Q

What drug usually cause amnesia

A

alcohol

717
Q

A conscious memory that covers for another memory that is too painful to hold in the consciousness is

A

screen memory

718
Q

Which test is most useful in early diagnosis of AD

A

10-item WORD list learning task

719
Q

age that corticospinal tract complete myelination

A

3 years old

720
Q

ALS wad are the hallmarks

A

weakness, fasciculation and brisk reflex

721
Q

exam finding suggest L5 radiculopathy in pt with back pain and foot drop

A

weakness of ankle inversion

722
Q

name 5 reflex that are frontal release reflex

A

snout, rooting, palmomental, grasp, suck

723
Q

what are the hallmarks of reflex for psaudobulbar palsy

A

hyperactive jaw jerk and gag reflex

724
Q

what wll result in cilary ganglion damage

A

mydriasis and hypersensitivity to miotic agents (dmg parasympathetic)

725
Q

Duchenne method of transmission

A

x linked

726
Q

hyperkalemic periodic paralysis is characterized y wad molecular deficits

A

sodium channel inactivation

727
Q

meralgia paresthetica usually affects wad

A

anterolateral thigh

728
Q

which antibiotics can cause or precipitate acute myasthenia

A

ciprofloxacin

729
Q

conduction block in NCS indicates what

A

focal demyelination

730
Q

the target site for DBS for essential tremor is

A

ventral intermediate thalamus

731
Q

wad does transcutaneous electrical nerve stimulation is for

A

peripheral neuralgia

732
Q

Horner’s syndrome is associated with lesion in where

A

superior cervical ganglion (sympathetic)

733
Q

first line for tics

A

alphas 2 adrenergic agonist

734
Q

which drugs in parkinsonism has been associated with sudden sleep attacks

A

ropinirole

735
Q

relationship between lamotrigine and oral contraceptive

A

lamo can be decrease

736
Q

common side effects of rivastigmine

A

bradycardia

737
Q

wad conditions happen in increased frequency in pt with HIV on long term HAART

A

hepatotoxicity

738
Q

topiramate affect which neurotransmitter receptor

A

GABA-A

739
Q

which medication for insomnia is most likely cause amnestic cognitive impairment

A

temazepam

740
Q

what does functional MRI measure

A

detects blood flow

741
Q

which MRI techniques is most likely reveal early signs of ischemic stroke

A

diffused weights MRI

742
Q

post cardiac arrest comatose patients eeg usually shows what

A

burst suppression pattern

743
Q

EEG biofeedback is efficacious for what disroder

A

GAD

744
Q

antiepileptic for juvenile myoclonic epilepsy

A

valproate

745
Q

which sleep stage is most important in restoring altered functions that results frim prolonged sleep deprivation

A

stage 4

746
Q

which findings on multiple sleep latency test confirms diagnosis of narcolepsy

A

decreased rem latency

747
Q

enuresis is a REM or non REM sleep problems

A

NON REM

748
Q

treatment of hungtinton chorea

A

haloperidol

749
Q

multifocal myoclonus in a comatose patient indicates

A

metabolic encephalopathy

750
Q

earliest symptoms of tourettes

A

eye blinking n head jerking

751
Q

most significant risk of tardive dyskinesia

A

advanced age (others: female, presence of mood disorder)

752
Q

good antidepressant for ADHD

A

bupropion

753
Q

most common comorbidity in pt with anxiety disorder is

A

another anxiety disorder

754
Q

when compared to younger adults, anxiety disorder in adults over 65 have

A

less comorbid alcohol abuse

755
Q

what predicts bipolarity in adolescents with depression

A

psychotic symptoms

756
Q

what meds can you add to lithium for tx resistant bipolar depression and is least likely to induce rapid cycling/mixed state

A

bupropion

757
Q

what is treatment of choice for bipolar with rapid cycling

A

valproate

758
Q

what is the following subjective effects is the basis of the appeal of MDMA

A

connectedness to others

759
Q

what drug of abuse that does not depend on specific neuronal membrance binding sites

A

alcohol

760
Q

what substance is only detected in urine for 7-12 hours after ingestion

how about 1-2 days

A

alcohol

amphetamines

761
Q

what is the most effective initial treatment for pt with PCP intoxication

A

urine acidification
give ammonium chloride

halo /benzo

762
Q

what substance is a common cause of f;ashback

A

cannabis

763
Q

what symptoms of nicotine withdrawal may persist in patient for up to 6 months

A

increased appetite

764
Q

what is speedball

what is candy flipping

A

speedball: heroin and cocaine

candy flipping: LSD and MDMA

765
Q

what phenomena is most typical of hallucinogen

A

illusions

766
Q

reducing the intensity of an addicts reaction to environmental reminders of the drug use us the goal of wad intervention

A

cue exposure treatment

767
Q

what is the molecular mechanism of ethanol causes intoxication

A

NDMA antagonism, GABA agonism

768
Q

patterns of drinking in women alcoholics compared to men

compared to men, woman also who abuse alcohol also more likey to have

A

solitary drinking

axis 1 diagnosis

769
Q

types of alcoholics

Cloninger’s

A

Type I alcoholics (late onset) want to avoid harm and seek social rewards; countered by low novelty. Type II alcoholics have the opposite qualities; they are considered high novelty with low levels of harm avoidance and reward-seeking behavior.

770
Q

Most serious effect of disulfiram when on alcohol

A

hypotension

771
Q

what drug is used to start autonomic symptoms associated with heroin withdrawal

A

clonidine

772
Q

adverse effect of methadone maintenance treatment for opioid dependence

A

hypogonadism

773
Q

what is the benefit of buprenorphine compared to methadone taper in detox from opiate depedance

A

less risk of respiratory suppression

774
Q

factor most predictive of effective methadone TX

A

total daily dose

775
Q

which of the following produces the best outcome in terms of drug consumptions and criminal behavior for heroin dependent

A

maintenance of methadone

776
Q

a substance of abuse with powerful reinforce effect

A

cocaine

777
Q

what drugs u can see talc granulomas

A

ccurs in intravenous drug addicts who also inject tablets intended for oral use
eg: Six different medications have been reported to be associated with talc granulomas in addicts: methylphenidate (Ritalin), methadone, tripelennamine (Pyribenzamine), propoxyphene (Darvon), phenmetrazine (Preludin), and amphetamines;

778
Q

what cognitive function will be better in 80 years ld after treatment of depressant

A

information processing speed

779
Q

complication of anorexia nervosa least likely to resolve after restoring weight is

A

osteoporosis

780
Q

risk factor for developing bulimia

A

sexual abuse

781
Q

wad ecg shows in pt with purging

A

t wave flattening and u wave

782
Q

wad is aquaporin 4 antibody indicates

A

Neuromyelitis optica , possibly a subtype of MS

783
Q

metachromatic leukodystrophy associated with what enzyme deficiency

A

arylsulfatase

784
Q

function of cisregulatory elements in gene expression

A

mediators of transcriptional activity

785
Q

wad is most commonly seen in pt with narcolepsy

A

HLA-DR2

786
Q

genetic linkage studies investigate what in medico psychiatric research

A

co segregation of genes during meiosis

787
Q

polymerase chain reaction (PCR) used in genetic linkage studies involves

A

amplification of microsatellite markers

788
Q

What is commonly associated with conversion d/o?

A

Low intelligence

789
Q

The first-line treatment for retentive encopresis:

A

Biofeedback

790
Q

Most common time for pt w/ schizophrenia to attempt suicide is during

A

Recovery phase of the illness

791
Q

Which of the following is the leading cause of child maltreatment fatalities?

A

Head injuries

792
Q

What symptom commonly develops relatively late in children with PTSD?

A

SENSE OF FORESHORTENED FUTURE

793
Q

What symptom is more likely to occur in acute stress d/o than in PTSD?

A

REDUCTION IN AWARENESS OF SURROUNDINGS

794
Q

What eeg read Correlates to a positive response to ECT?

A

Increase etc induced frontal delta activity

795
Q

ECT is least likely to be effective for patients who have?

A

Chronic schizophrenia

796
Q

Iq score usually stabilized at

A

7 years old

797
Q

What would be a useful screening test to evaluate an 8 y/o child’s academic performance?

A

Wide range achievement test

798
Q

Thematic apperception test is used for

A

INTERFERING MOTIVATIONAL ASPECTS OF BEHAVIOR

799
Q

What drug has a curvilinear therapeutic window?

A

Nortriptyline

800
Q

What drug is useful in the Rx of urinary retention secondary to TCA therapy

A

Bethanecol

801
Q

Serotonergic antidepressants are appropriate treatment for depression in 54 y/o pt with recent coronary artery bypass graft surgery because they:

A

Inhibit platelet functioning

802
Q

First pass effect refers to which of the following aspects of a med’s metabolism?

A

Presystemic elimination

803
Q

What can cause seizure in an overdose

A

Clomipramine

804
Q

Antidepressant that cause Parkinson’s syndrome

A

Amoxapine

805
Q

Most frequent side effect of Maoi

A

Hypotension

806
Q

Which tricyclics antidepressant has the most potent antihistamine effects

A

Doxepin

807
Q

What is a sleep disturbance likely to occur after initiating a trial of an SSRI?

A

Bruxism

808
Q

Which antidepressant is safest in seizure disorders and depression?

A

Fluoxetine

809
Q

what is the most common complication of homocysteine deficiency

A

stroke

810
Q

what can cause moderate to severe renal impairment

A

paliperidone

811
Q

which receptor of antipsychotic drug cause orthostatic hypotension

A

adrenergic 1 blockage

also tachycardia

812
Q

antipsychotic associated with development of cataract

A

quetiapine

813
Q

therapeutic effect of 2nd generation antipsychotic on negative symptoms of schizophrenia is thought to be related to induction of expression of what area of the brain

A

prefrontal cortex

814
Q

pt over 65 are less likely to tolerate higher dose of antipsychotic due to

A

dec hepatic metabolism

815
Q

which benzo accumulates with repeated administration should be avoided in chronic renal failure and most likely accumulate with repeated dosing

A

diazepam

816
Q

what benzo has an active metabolite

A

chlordiazepoxide

817
Q

when to treat paracet overdose

A

Serum acetaminophen concentration drawn at four hours or more following acute ingestion of an immediate-release preparation is above the “treatment” line of the treatment nomogram for acetaminophen poisoning (figure 1).

●A suspected single ingestion of greater than 150 mg/kg (7.5 g total dose regardless of weight) in a patient for whom the serum acetaminophen concentration will not be available until more than eight hours from the time of the ingestion.

●Patient with an unknown time of ingestion and a serum acetaminophen concentration >10 mcg/mL (66 micromol/L).

●Patient with a history of acetaminophen ingestion and any evidence of liver injury.

818
Q

risk of hepatoxicity will peak in how many hours after acetaminophen overdose

A

72-96 hours

819
Q

sudden death in children taking which meds

A

tricyclics

820
Q

diphenhydramine’s ability to treat acute dystonia is due to wad action

A

muscarinic -1

821
Q

buprenorphine’s advantage over clonidine in the management of patient with opioid withdrawal, included better control of wad symptoms

A

cravings

822
Q

what substance 9supplement) is associated with risk of bleeding when taken with antiplatelet or warfarin

A

ginkgo biloba

823
Q

coinidine mechanism of action

A

alpha 2 agonist

824
Q

which meds is associated with benign maculopapular rash in 10-15% of pt’s within first 3 weeks

A

carbamazepine

825
Q

most common reason pt discontinue valproate

A

weight gain

826
Q

wad do give for pt. with lithium induced polyuria

A

amiloride

827
Q

wad is the most common cardiovascular disturbance for lithium

A

benign t wave changes

828
Q

therapeutic technique where therapy instructs the patient to hold on a symptoms

A

paradoxical intervention

829
Q

what kind of pt wt PTSD will have the most favorable prognosis in CBT involving exposure therapy

A

victim of random violent assaults’

830
Q

which is a target of DBT in older adults that is not otherwise included in standard DBT protocol

A

emotional constriction

831
Q

Major task of a group therapy during initial engagement phase is

A

determining limits f emotional safety

832
Q

what type of group therapy is based on unit functioning to maintain its own homeostasis of interacting

A

family group therapy

833
Q

hypnosis would be contraindicated in the treatment of patient with

A

paranoia

834
Q

Process by which children modify existing schemas to adapt to new experiences is:

A

Accommodation

835
Q

When compared with adult-onset schizophrenia, children with schizophrenia have

A

SIMILAR DEFICITS IN ATTENTION, LEARNING AND ABSTRACTIon

836
Q

Assuming there is no significant difference in 2 random samples of population is

A

Null hypothesis

837
Q

What is the legal process that asks the court to immediately evaluate if a pt has been hospitalized w/o due process of law?

A

Writ of habeas corpus

838
Q

Wad drug is unchanged in urine

A

Gabapentin

839
Q

Which of the following brain imaging technique measures neuronal glucose metabolism

A

Pet